Results 41 to 50 of about 826,759 (374)

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis)

open access: yesHaematologica, 2016
Increased fetal hemoglobin levels lessen the severity of symptoms and increase the lifespan of patients with sickle cell disease. Hydroxyurea, the only drug currently approved for the treatment of sickle cell disease, is not effective in a large ...
Angela Rivers   +9 more
doaj   +1 more source

Acute fetal anemia diagnosed by middle cerebral artery Doppler velocimetry in stage v twin-twin transfusion syndrome. [PDF]

open access: yes, 2011
In stage V twin-twin transfusion syndrome (TTTS), up to 50% of surviving twins die or experience permanent disabilities, likely due to acute intertwin hemorrhage resulting in sudden severe anemia of the survivor.
Friedrich, Esther   +3 more
core   +2 more sources

Diagnosis of Severe Fetal Anemia Based on Perinatal Outcomes: A Comparative Analysis of the Current Reference Values

open access: yesAnemia, 2013
Objectives. To compare current criteria for severe fetal anemia diagnosis. Methodology. A cohort study analyzed 105 alloimmunized fetuses that underwent cordocentesis due to risk of anemia.
Zilma Silveira Nogueira Reis   +5 more
doaj   +1 more source

Metabolic persistence of fetal hemoglobin [PDF]

open access: yesBlood, 1995
Hereditary persistence of fetal hemoglobin (HPFH) has typically been ascribed to mutations in the beta-globin gene cluster. Pharmacologic agents, including the short-chain fatty acid butyrate, have been shown to upregulate fetal and embryonic globin gene expression. In this report we investigate the possibility that metabolic derangements characterized
Jane A. Little   +3 more
openaire   +2 more sources

Evaluation of Glycated Albumin (GA) and GA/Hba1c Ratio for Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review [PDF]

open access: yes, 2017
Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and ...
Abdolrahim, Mojgan   +6 more
core   +3 more sources

Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

open access: yesRevista Brasileira de Hematologia e Hemoterapia, 2012
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers.
Darcielle Bruna Dias Elias   +5 more
doaj   +1 more source

Vitamins and Perinatal Outcomes Among HIV-Negative Women in Tanzania. [PDF]

open access: yes, 2007
Prematurity and low birth weight are associated with high perinatal and infant mortality, especially in developing countries. Maternal micronutrient deficiencies may contribute to these adverse outcomes. In a double-blind trial in Dar es Salaam, Tanzania,
Allen LH   +16 more
core   +1 more source

Effects of maternal subnutrition during early pregnancy on cow hematological profiles and offspring physiology and vitality in two beef breeds [PDF]

open access: yes, 2019
This experiment evaluated the effects of subnutrition during early gestation on hematology in cows (Bos Taurus) and on hematological, metabolic, endocrine, and vitality parameters in their calves.
Almaguer C.   +9 more
core   +2 more sources

Flowcytometric assessment of fetomaternal hemorrhage during external cephalic version at term [PDF]

open access: yes, 2008
External cephalic version (ECV) at term is a safe procedure and reduces the incidence of cesarean sections for breech presentation. One of the known complications, however, is an ECV-related disruption of the placental barrier and a subsequent ...
Friese, Klaus   +6 more
core   +2 more sources

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model

open access: yesHaematologica, 2010
Hydroxyurea has proven clinical efficacy in patients with sickle cell disease. Potential mechanisms for the beneficial effects include fetal hemoglobin induction and the reduction of cell adhesive properties, inflammation and hypercoagulability.
Jeffrey D. Lebensburger   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy