Results 21 to 30 of about 52,157 (235)

The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]

, 2019
Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca, Nanni, Monica, Persechino, Flavia, Ranieri, Danilo, Torrisi, Maria Rosaria   +4 more
core   +1 more source

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

Cholesterol: Enhancing FGF2 translocation in unconventional secretion

Journal of Cell Biology, 2022
Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by cholesterol, which enhances PI(4,5)P2 accessibility to
Haodong Wang, Min Zhang, Liang Ge
openaire   +2 more sources

mRNA sequencing reveals the distinct gene expression and biological functions in cardiac fibroblasts regulated by recombinant fibroblast growth factor 2 [PDF]

PeerJ, 2023
After myocardial injury, cardiac fibroblasts (CFs) differentiate into myofibroblasts, which express and secrete extracellular matrix (ECM) components for myocardial repair, but also promote myocardial fibrosis.
Changye Sun, Mengru Bai, Yangyang Jia, Xiangqin Tian, Yonglong Guo, Xinhui Xu, Zhikun Guo   +6 more
doaj   +2 more sources

Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. [PDF]

, 2017
Haematopoiesis is an essential process in early vertebrate development that occurs in different distinct spatial locations in the embryo that shift over time.
Aggio, Julian, Campbell, Clyde, Marquez, Gabriel, Stachura, David L, Traver, David, Wolf, Anja, Wright, Francis   +6 more
core   +1 more source

Sprouty2 mediated tuning of signalling is essential for somite myogenesis [PDF]

, 2015
Background: Negative regulators of signal transduction cascades play critical roles in controlling different aspects of normal embryonic development.
A Borycki, A Faedo, A Sasaki, AA Mailleux, AC Rios, Andrea Münsterberg, B Christ, B Hausott, C de Alvaro, C Marcelle, C Zhang, CC Lee, D Chambers, D Sayed, D Sweetman, D Sweetman, G Christofori, G Minowada, GF Mok, Grant Wheeler, H Hanafusa, HJ Kim, HM Poppleton, I Laziz, JD Tefft, JM Mason, JM Mason, K Matsumura, K Shim, Katarzyna Goljanek Whysall, L Cheng, L Chi, L Chi, LE Alvares, M Abu-Elmagd, M Buckingham, M Ishida, M Schmidt, M Schmidt, MA Basson, MA Cabrita, MC Eblaghie, MJ Frank, Muhammad Abu-Elmagd, N Hacohen, OD Klein, P Li, PA Branney, S Eloy-Trinquet, TG Smith, V Hamburger, Y Yigzaw   +51 more
core   +2 more sources

Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation. [PDF]

PLoS ONE, 2012
Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1(+) hematopoietic stem/progenitor cells that are engineered to express a ...
Xianmei Meng, David J Baylink, Matilda Sheng, Hongjie Wang, Daila S Gridley, K-H William Lau, Xiao-Bing Zhang   +6 more
doaj   +1 more source

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]

, 2011
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson, Beenken, Bochukova, Burgar, Celli, Cohen, De Moerlooze, Duan, Duchesne, Ezzat, Fairbanks, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hanneken, Ibrahimi, Jang, Jang, Jang, John K. Heath, Jones, Kawano, Klein, Kuro-o, Lee M. Wheldon, Lewis, Maquat, McKeehan, Mendell, Meyers, Miki, Mohammad K. Hajihosseini, Muhlemann, Naila Khodabukus, Naski, Nelson, Oldridge, Peters, Polanska, Ricol, Saito, Sekine, Slaney, Smith, Susannah J. Patey, Takaishi, Tanimoto, Terada, Terence G. Smith, Tsang, Tsukuno, Werner, Wheldon, Wilkie, Yamaguchi, Zhang   +57 more
core   +3 more sources

A pro‐inflammatory signature mediates FGF2‐induced angiogenesis [PDF]

Journal of Cellular and Molecular Medicine, 2008
AbstractFibroblast growth factor‐2 (FGF2) is a potent angiogenic growth factor. Here, gene expression profiling of FGF2‐stimulated microvascular endothelial cells revealed, together with a prominent pro‐angiogenic profile, a pro‐inflammatory signature characterized by the up‐regulation of pro‐inflammatory cytokine/chemokines and their receptors ...
ANDRÉS G, LEALI, Daria, MITOLA, Stefania Maria Filomena, COLTRINI, Daniela, CAMOZZI M, CORSINI M, BELLERI, Mirella, HIRSCH E, SCHWENDENER R, CHRISTOFORI G, ALCAMÍ A, PRESTA, Marco   +11 more
openaire   +3 more sources

Hypoxic regulation of the expression of anti-angiogenic genes in U87 glioma cells with loss of function of ern1 signaling enzyme

Біологічні студії, 2012
The angiogenesis is an important component of tumor growth and tightly associated with hypoxia. The expression level of genes related to regulation of angiogenesis (BAI2, SPARC, TIMP1, TIMP2, TIMP3, TIMP4, THBS1, THBS2, ADAMTS5 and FGF2) in glioma ...
K. I. Kubaichuk, D. O. Minchenko, S. V. Danilovskyi, A. Y. Kuznetsova, A. K. Jassim, O. H. Minchenko   +5 more
doaj   +1 more source