Results 191 to 200 of about 34,994 (236)

FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention

International Journal of Molecular Sciences, 2020
Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors involved in many biological processes. Deregulated FGFR signaling plays an important role in tumor development and progression in different cancer types.
Antonella de Luca, Riziero Esposito Abate, Guglielmo Nasti   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

FGFR Mutations and Plagiocephaly

Journal of Craniofacial Surgery, 2008
FGFR genes have important effects on bone development, and mutations in 4 "hot spot" exons of FGFR1-3 are found in many patients with craniosynostosis and some with synostotic plagiocephaly. To test the hypothesis that sequence variation in those exons predisposes toward developmental bone deformation, we assayed 160 children with nonsynostotic ...
Valairat, Dhamcharee, Richard G, Boles
openaire   +2 more sources

The Hydra FGFR, Kringelchen, partially replaces the Drosophila Heartless FGFR

Development Genes and Evolution, 2012
Fibroblast growth factor receptors (FGFR) are highly conserved receptor tyrosine kinases, and evolved early in metazoan evolution. In order to investigate their functional conservation, we asked whether the Kringelchen FGFR in the freshwater polyp Hydra vulgaris, is able to functionally replace FGFR in fly embryos.
Anja, Rudolf, Christine, Hübinger, Katrin, Hüsken, Angelika, Vogt, Nicole, Rebscher, Susanne-Filiz, Onel, Renate, Renkawitz-Pohl, Monika, Hassel   +7 more
openaire   +2 more sources

FGFR signalling in women's cancers

The International Journal of Biochemistry & Cell Biology, 2013
FGFs, in a complex with their receptors (FGFRs) and heparan sulfate (HS), are responsible for a range of cellular functions, from embryogenesis to metabolism. Both germ line and somatic FGFR mutations are known to play a role in a range of diseases, most notably craniosynestosis dysplasias, dwarfism and cancer. Because of the ability of FGFR signalling
Abbie E, Fearon, Charlotte R, Gould, Richard P, Grose   +2 more
openaire   +2 more sources

FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung

Development, 1998
ABSTRACT Mammalian lungs begin as an outpocket of the foregut, and depend on multiple stages of branching morphogenesis and alveogenesis to reach their final form. An examination of fgf receptor gene expression indicated that all four receptors (fgfr-1 to fgfr-4) are expressed in postnatal lungs at varying levels.
M, Weinstein, X, Xu, K, Ohyama, C X, Deng   +3 more
openaire   +2 more sources

FGFR Inhibition in Urothelial Carcinoma

European Urology
The 2024 US Food and Drug Administration approval of erdafitinib for the treatment of metastatic urothelial carcinoma (mUC) with FGFR3 alterations ushered in the era of targeted therapy for bladder cancer. In this review, we summarize the effects of FGFR pathway alterations in oncogenesis, clinical data supporting FGFR inhibitors in the management of ...
Roger, Li, Joshua, Linscott, James W F, Catto, Siamak, Daneshmand, Bishoy M, Faltas, Ashish M, Kamat, Joshua J, Meeks, Andrea, Necchi, Benjamin, Pradere, Jeffrey S, Ross, Michiel S, van der Heijden, Bas W G, van Rhijn, Yohann, Loriot   +12 more
exaly   +3 more sources

FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies

Annals of Oncology, 2022
Vivek Subbiah, David Smith, T Ji
exaly