Results 211 to 220 of about 35,836 (258)

The multi-kinase inhibitor tinengotinib as monotherapy or combined with atezolizumab in advanced solid tumors: a phase Ib/II trial. [PDF]

Nat Commun
Zhang P, Niu Z, Guo H, Zhang M, Jiang S, Cao B, He C, Hou X, Zhang J, Yuan J, Zhu Y, Yu Y, Sun C, Peng P, Fan J, Gong J, Zhou J, Shen L.   +17 more
europepmc   +1 more source

<i>FGFR3</i> Gene Alterations and Protein Expression in Paired TURBT and Radical Cystectomy Archival Specimens of Muscle-Invasive Bladder Cancer. [PDF]

Int J Mol Sci
Miyake M, Nishimura N, Ohnishi S, Oda Y, Shimizu T, Owari T, Iida K, Tachibana A, Tomizawa M, Ohnishi K, Hori S, Morizawa Y, Gotoh D, Nakai Y, Tanaka N.   +14 more
europepmc   +1 more source

Ex Vivo Tumor-Derived Organoid Pharmacotyping Identifies Personalized Therapeutic Options for Patients with Biliary Tract Cancer. [PDF]

Cancer Res Commun
Richardson AB, Chatterjee P, Rosati R, Rajewski A, Diaz RL, Appleyard LR, Pereira S, Bernard B, Javle MM, King GG, Diehl A, Harris WP, Roychowdhury S, Kemp CJ, Grandori C.   +14 more
europepmc   +1 more source

FGFR Inhibitors in Oncology: Insight on the Management of Toxicities in Clinical Practice

Cancers, 2021
Fibroblast Growth Factor receptor (FGFR) pathway aberrations have been implicated in approximately 7% of the malignancies. As our knowledge of FGFR aberrations in cancer continues to evolve, FGFR inhibitors emerged as potential targeted therapeutic ...
Sri Harsha Tella, Milind Javle, Amit Mahipal   +2 more
exaly   +2 more sources

FGFR a promising druggable target in cancer: Molecular biology and new drugs

Critical Reviews in Oncology/Hematology, 2017
Introduction The Fibroblast Growth Factor Receptor (FGFR) family consists of Tyrosine Kinase Receptors (TKR) involved in several biological functions.
Tindara Franchina, Rafael Sirera, Shahanavaj Khan   +2 more
exaly   +2 more sources

FGF/FGFR Signaling in Hepatocellular Carcinoma: From Carcinogenesis to Recent Therapeutic Intervention

Cancers, 2021
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, ranking third in cancer deaths worldwide. Over the last decade, several studies have emphasized the development of tyrosine kinase inhibitors (TKIs) to target the aberrant ...
Yijun Wang, Tongyue Zhang, Limin Xia
exaly   +2 more sources

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FGFR Mutations and Plagiocephaly

Journal of Craniofacial Surgery, 2008
FGFR genes have important effects on bone development, and mutations in 4 "hot spot" exons of FGFR1-3 are found in many patients with craniosynostosis and some with synostotic plagiocephaly. To test the hypothesis that sequence variation in those exons predisposes toward developmental bone deformation, we assayed 160 children with nonsynostotic ...
Valairat, Dhamcharee, Richard G, Boles
openaire   +2 more sources