Results 221 to 230 of about 35,836 (258)

The Hydra FGFR, Kringelchen, partially replaces the Drosophila Heartless FGFR

Development Genes and Evolution, 2012
Fibroblast growth factor receptors (FGFR) are highly conserved receptor tyrosine kinases, and evolved early in metazoan evolution. In order to investigate their functional conservation, we asked whether the Kringelchen FGFR in the freshwater polyp Hydra vulgaris, is able to functionally replace FGFR in fly embryos.
Anja, Rudolf, Christine, Hübinger, Katrin, Hüsken, Angelika, Vogt, Nicole, Rebscher, Susanne-Filiz, Onel, Renate, Renkawitz-Pohl, Monika, Hassel   +7 more
openaire   +2 more sources

FGFR signalling in women's cancers

The International Journal of Biochemistry & Cell Biology, 2013
FGFs, in a complex with their receptors (FGFRs) and heparan sulfate (HS), are responsible for a range of cellular functions, from embryogenesis to metabolism. Both germ line and somatic FGFR mutations are known to play a role in a range of diseases, most notably craniosynestosis dysplasias, dwarfism and cancer. Because of the ability of FGFR signalling
Abbie E, Fearon, Charlotte R, Gould, Richard P, Grose   +2 more
openaire   +2 more sources

FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung

Development, 1998
ABSTRACT Mammalian lungs begin as an outpocket of the foregut, and depend on multiple stages of branching morphogenesis and alveogenesis to reach their final form. An examination of fgf receptor gene expression indicated that all four receptors (fgfr-1 to fgfr-4) are expressed in postnatal lungs at varying levels.
M, Weinstein, X, Xu, K, Ohyama, C X, Deng   +3 more
openaire   +2 more sources

FGFR Inhibition in Urothelial Carcinoma

European Urology
The 2024 US Food and Drug Administration approval of erdafitinib for the treatment of metastatic urothelial carcinoma (mUC) with FGFR3 alterations ushered in the era of targeted therapy for bladder cancer. In this review, we summarize the effects of FGFR pathway alterations in oncogenesis, clinical data supporting FGFR inhibitors in the management of ...
Roger, Li, Joshua, Linscott, James W F, Catto, Siamak, Daneshmand, Bishoy M, Faltas, Ashish M, Kamat, Joshua J, Meeks, Andrea, Necchi, Benjamin, Pradere, Jeffrey S, Ross, Michiel S, van der Heijden, Bas W G, van Rhijn, Yohann, Loriot   +12 more
exaly   +3 more sources

FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies

Annals of Oncology, 2022
Vivek Subbiah, David C. Smith, T Ji
exaly  

Acquired resistance to selective FGFR inhibitors in FGFR-altered cholangiocarcinoma

European Journal of Cancer, 2020
L. Goyal, I. Baiev, K. Zhang, S. Dalgai, R.T. Shroff, R.K. Kelley, N. Uboha   +6 more
openaire   +1 more source

FGFR inhibitors for advanced cholangiocarcinoma

The Lancet Oncology, 2020
Tian, Yang, Lei, Liang, Ming-Da, Wang, Feng, Shen   +3 more
openaire   +2 more sources

Biological Significance and Targeting of the FGFR Axis in Cancer

Cancers, 2021
Richard Grose, Athina-Myrto Chioni
exaly  

Bicyclic heterocycles as FGFR inhibitors

2021
XU YAO, VECHORKIN OLEG, NGUYEN MINH, QI CHAO, WANG ANLAI, WITTEN MICHAEL, YE HAI FEN, ZHANG KE, ZHAO PENG, YAO WENQING   +9 more
  +17 more sources

Derivatives of an FGFR inhibitor

2021
TAO MING, BOER JASON
openaire   +3 more sources