Results 91 to 100 of about 35,241 (222)
Arthritis &Rheumatology, Accepted Article.Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong +13 more
wiley +1 more source
FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. [PDF]
PLoS ONE, 2013 Emerging evidence suggests that some cancers contain a population of stem-like TICs (tumor-initiating cells) and eliminating TICs may offer a new strategy to develop successful anti-cancer therapies.
Sungeun Kim +10 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li +10 more
wiley +1 more source
Cancer Management and Research, 2021 Dong-Wei Fu, Ai-Chun Liu Department of Hematology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, People’s Republic of ChinaCorrespondence: Ai-Chun LiuDepartment of Hematology, Harbin Medical University, Cancer Hospital ...
Fu DW, Liu AC
doaj
Journal of Clinical Laboratory Analysis, EarlyView.RNA‐based fusion panels using targeted next‐generation sequencing of formalin‐fixed paraffin‐embedded (FFPE) tumour tissue specimens have been used for a few years from patients with various tumour types to detect rearrangements/fusions. Using the bioinformatic approaches the data obtained from RNA sequencing (RNAseq) can also be used for small ...
Pranav Dorwal +14 more
wiley +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objectives Acquired cholesteatoma is an abnormal and invasive growth of keratinized squamous epithelial cells in the middle ear. The study aims to explore the role of exosomal miRNAs in the pathogenesis of acquired cholesteatoma and their potential in clinical application.
Qi Tang +12 more
wiley +1 more source
Brain Pathology, EarlyView.We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Sha‐Sha Hu +3 more
wiley +1 more source
A Case of Crouzon's Syndrome with a True Human Tail
Journal of Plastic and Reconstructive Surgery, 2023 A human tail complicated by Crouzon syndrome is extremely rare, with only eight reported cases of human tails associated with Crouzon syndrome. A human tail is defined as a true human tail or a pseudo-human tail according to the presence or absence of ...
Nobuhiro Ando +4 more
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Finding More in Less: Precision Medicine for Pancreatic Cancer Using Residual Cytology Samples
Cytopathology, EarlyView.The study evaluates the use of residual liquid‐based cytology (LBC) samples from pancreatic ductal adenocarcinoma (PDAC) for molecular analysis. It shows that LBC samples preserve nucleic acid quality and remain suitable for next‐generation sequencing (NGS) and MSI testing even after prolonged storage, underscoring their value when other samples are ...
Raquel Antón‐Peñalver +17 more
wiley +1 more source
Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration
Frontiers in Pharmacology, 2020 Fgfr1 (Fibroblast growth factor receptor 1) and Fgfr2 are dynamically expressed during lung development, homeostasis, and regeneration. Our current analysis indicates that Fgfr2 is expressed in distal epithelial progenitors AT2, AT1, club, and basal ...
Tingting Yuan +8 more
doaj +1 more source