Precision Antibody Therapy in Gastric and Gastroesophageal Cancer: Targeting FGFR2b, CLDN18.2, and VEGFR2 [PDF]
CellsGastric and gastroesophageal junction (G/GEJ) adenocarcinomas remain among the most aggressive and lethal malignancies globally. Most patients are diagnosed at advanced stages and respond poorly to conventional chemotherapy, highlighting the urgent ...
Vivian Chetachi Eziefula Njoku +4 more
doaj +5 more sources
HPV16 E5 and KGFR/FGFR2b interplay in differentiating epithelial cells [PDF]
Oncotarget, 2013 The E5 oncogenic protein of the human papillomavirus type 16 (HPV16 E5) cooperates in epithelial transformation perturbing the behaviour of differentiating suprabasal cells. Among the receptor tyrosine kinases deregulated by 16E5 expression, the key paracrine mediator of epithelial homeostasis keratinocyte growth factor receptor (KGFR/FGFR2b) is ...
PURPURA, VALERIA +3 more
core +10 more sources
The role of Fgf10/Fgfr2b signaling during lung development [PDF]
, 2021 Fgf10 among others is one of the most important genes of the developing lung from the beginning of organogenesis. It plays a decisive role in controlling epithelial morphogenesis (Chao et al. 2016). It is obvious to assume that Fgf10 might play an important role in both lung development and lung repair after injury.
Sedighi, Jamschid +1 more
openaire +3 more sources
FGFR2b In Gastric Cancer: Translating a Therapeutic Target Into a Reliable Biomarker [PDF]
CancersFibroblast growth factor receptor 2b (FGFR2b) has become an increasingly important therapeutic target in gastric and gastroesophageal junction cancer, particularly with the clinical development of FGFR2b-directed antibody therapy. However, its translation into routine treatment selection is not straightforward.
Catalin-Bogdan Satala +2 more
exaly +3 more sources
N-Terminal Helix Formation and Dimer–Monomer Transition of FGF10 in Specific Recognition of FGFR2b [PDF]
FEBS JournalFGF10 specifically recognizes FGFR2b with a conformational change of the N‐terminal part. The N‐terminal part of FGF10 and two loops of FGFR2b constituting the interaction interface are the most varied regions in FGF and FGFR family members. FGF10 shows a concentration‐dependent dimerization.
Sun-Shin Cha, Hyunjae Park, Lin-Woo Kang
exaly +3 more sources
Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors [PDF]
Development, 2010 Rodent incisors regenerate throughout the lifetime of the animal owing to the presence of epithelial and mesenchymal stem cells in the proximal region of the tooth. Enamel, the hardest component of the tooth, is continuously deposited by stem cell-derived ameloblasts exclusively on the labial, or outer, surface of the tooth.
Sara, Parsa +11 more
openaire +3 more sources
Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCδ and PKCα [PDF]
Cell Death & Disease, 2018 AbstractThe tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular contexts, including keratinocytes.
Rosato, Benedetta +4 more
openaire +4 more sources
Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb development. [PDF]
PLoS ONE, 2013 The vertebrate limbs develop through coordinated series of inductive, growth and patterning events. Fibroblast Growth Factor receptor 2b (FGFR2b) signaling controls the induction of the Apical Ectodermal Ridge (AER) but its putative roles in limb ...
Soula Danopoulos +12 more
doaj +2 more sources
Clinical Characterization of FGFR2b Expression in Patients With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma [PDF]
ESMO OpenFibroblast growth factor receptor 2b (FGFR2b) is a novel protein biomarker expressed in gastric and gastroesophageal junction tumors (GC/GEJC). Phase III trials are evaluating the efficacy and safety of FGFR2b-targeting therapies. However, features of FGFR2b-expressing tumors and co-occurrence of FGFR2b expression with currently actionable biomarkers ...
A Kawazoe, D Kotani, J Hawkins
exaly +4 more sources
Journal of Investigative Surgery, 2022 Background The relapse rate in non-small cell lung cancer (NSCLC) is high, even in localized disease, suggesting that the current approach to pathological staging is insufficiently sensitive to detect occult micrometastases present in resected lymph ...
Ivan Macia +11 more
doaj +2 more sources