Results 41 to 50 of about 2,012 (174)
Identification of a novel subset of alveolar type 2 cells expanding following pneumonectomy, responding differently to Fgfr2b deletion and enriched in PD-L1 [PDF]
, 2020 Alveolar type 2 (AT2) cells are a heterogeneous population; where specialized AT2 subpopulations within this lineage exhibit stem cell properties. However, the existence of quiescent, immature cells within the AT2 lineage, which become activated during ...
Ahmadvand, Negah
core +1 more source
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo [PDF]
Development, 2002 The mouse develops five pairs of mammary glands that arise during mid-gestation from five pairs of placodes of ectodermal origin. We have investigated the molecular mechanisms of mammary placode development using Lef1 as a marker for the epithelial component of the placode, and mice deficient for Fgf10 or Fgfr2b, both of which fail to develop normal ...
Arnaud André, Mailleux +9 more
openaire +2 more sources
Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switch
Cell Communication and Signaling, 2020 Background The epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) controls the entire program of keratinocyte differentiation via the sequential involvement of protein kinase C (PKC) δ and PKCα.
Danilo Ranieri +4 more
doaj +1 more source
Fibroblast Growth Factor 10 and Vertebrate Limb Development
Frontiers in Genetics, 2019 Early limb development requires fibroblast growth factor (Fgf)-mediated coordination between growth and patterning to ensure the proper formation of a functional organ.
Libo Jin +7 more
doaj +1 more source
Fibroblast Growth Factor 10 in Pancreas Development and Pancreatic Cancer
Frontiers in Genetics, 2018 The tenacious prevalence of human pancreatic diseases such as diabetes mellitus and adenocarcinoma has prompted huge research interest in better understanding of pancreatic organogenesis.
Rodrick Ndlovu +7 more
doaj +1 more source
FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium [PDF]
Development, 2011 The epicardium serves as a source of growth factors that regulate myocardial proliferation and as a source of epicardial-derived cells (EPDC), which give rise to interstitial cardiac fibroblasts and perivascular cells. These progenitors populate the compact myocardium to become part of the mature coronary vasculature and fibrous skeleton of the heart ...
Mónica, Vega-Hernández +3 more
openaire +2 more sources
PLoS ONE, 2021 PurposeThe role of fibroblast growth factor (FGF) in orbital fibroblasts (OFs) is rarely known. In this study, we investigated the effect of FGF10 on fibrosis and the inflammation mechanism of Graves' orbitopathy (GO).MethodsOrbital tissue from GO (n ...
Sun Young Jang +4 more
doaj +1 more source
Structural Biology of the FGF7 Subfamily
Frontiers in Genetics, 2019 Mammalian fibroblast growth factor (FGF) signaling is intricately regulated via selective binding interactions between 18 FGF ligands and four FGF receptors (FGFR1–4), three of which (FGFR1–3) are expressed as either epithelial (“b”) or mesenchymal (“c”)
Allen Zinkle, Moosa Mohammadi
doaj +1 more source
Cells, 2019 Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Monica Nanni +4 more
doaj +1 more source
Precision Detection of FGFR2b Protein Expression in Solid Tumors
Archives of Pathology & Laboratory MedicineContext.— Immunohistochemistry effectively reveals the heterogeneous nature of fibroblast growth factor receptor 2b (FGFR2b) expression and antigen accessibility across diverse tumor histologic types, a variability significantly influenced by tissue type and fixation quality, both of which profoundly impact ...
Autumn Sky Watson +9 more
openaire +3 more sources