Interplay between FGFR2b‐induced autophagy and phagocytosis: role of PLCγ‐mediated signalling [PDF]
Journal of Cellular and Molecular Medicine, 2017 AbstractSignalling of the epithelial splicing variant of the fibroblast growth factor receptor 2 (FGFR2b) induces both autophagy and phagocytosis in human keratinocytes. Here, we investigated, in the cell model of HaCaT keratinocytes, whether the two processes might be related and the possible involvement of PLCγ signalling.
Monica Nanni +4 more
openaire +3 more sources
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate [PDF]
Journal of Clinical Investigation, 2004 Classical research has suggested that early palate formation develops via epithelial-mesenchymal interactions, and in this study we reveal which signals control this process. Using Fgf10-/-, FGF receptor 2b-/- (Fgfr2b-/-), and Sonic hedgehog (Shh) mutant mice, which all exhibit cleft palate, we show that Shh is a downstream target of Fgf10/Fgfr2b ...
Rice, R +7 more
openaire +5 more sources
Journal of Clinical Oncology, 2017 4067 Background: FGFR2b-overexpressing gastric cancer is characterized by poor prognosis. FPA144, a humanized monoclonal IgG1 antibody that specifically binds to and blocks FGFR2b, has been engineered for enhanced antibody-dependent cell-mediated cytotoxicity (ADCC).
Daniel V.T. Catenacci +18 more
core +3 more sources
Reciprocal interactions of Fgf10/Fgfr2b modulate the mouse tongue epithelial differentiation
Cell and Tissue Research, 2011 The molecular mechanisms for epithelial differentiation have been studied by observing skin development in embryogenesis, but the early signaling modulations involved in tongue epithelial differentiation are not completely understood. Based on the gene expression patterns of the Fgf signaling molecules and previous results from Fgf10 and Fgfr2b ...
Kim, JY +11 more
core +6 more sources
The Role of Fibroblast Growth Factor 10 Signaling in Duodenal Atresia [PDF]
Frontiers in Pharmacology, 2020 IntroductionDuodenal atresia (DA) is a congenital bowel obstruction requiring major surgery in the first week of life. Three morphological phenotypes are described, reflecting increasing degrees of obstruction and discontinuity of the duodenum. The cause
Matthew L. M. Jones +15 more
doaj +2 more sources
Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. [PDF]
PLoS ONE, 2012 The signaling pathways that are essential for gastric organogenesis have been studied in some detail; however, those that regulate the maintenance of the gastric epithelium during adult homeostasis remain unclear.
Allison L Speer +5 more
doaj +2 more sources
The receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytes. [PDF]
PLoS ONE, 2011 The FGFRs trigger divergent responses, such as proliferation and differentiation, and the cell type as well as the context-dependent signaling are crucial for the functional outcome.
Francesca Belleudi +2 more
doaj +5 more sources
FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling [PDF]
BMC Biology, 2020 Background The formation of supernumerary teeth is an excellent model for studying the molecular mechanisms that control stem/progenitor cell homeostasis needed to generate a renewable source of replacement cells and tissues.
Jingyi Wu +17 more
doaj +5 more sources
Innovative pathological and therapeutic approaches for poorly cohesive gastric cancer [PDF]
Frontiers in OncologyPoorly cohesive gastric cancer (PCGC) represents a biologically distinct subtype of gastric cancer, characterized by diffuse growth, marked intratumoral heterogeneity, and a consistently worse prognosis compared with other histological subtypes.
Margherita Muratore +9 more
doaj +2 more sources
The structure-preserving spectral graph neural network for dual kinase inhibitors and synergy scoring in gastric cancer [PDF]
npj Digital MedicineThe therapeutic targeting of kinase signaling pathways represents a pivotal strategy in gastric cancer, yet the rational design of single agents capable of dual-kinase inhibition remains a challenge in precision oncology.
Yang Zhang +5 more
doaj +2 more sources