Results 31 to 40 of about 2,012 (174)

FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury

Stem Cell Reports, 2019
Summary: Idiopathic pulmonary fibrosis is a common form of interstitial lung disease resulting in alveolar remodeling and progressive loss of pulmonary function because of chronic alveolar injury and failure to regenerate the respiratory epithelium ...
Tingting Yuan, Thomas Volckaert, Elizabeth F. Redente, Seantel Hopkins, Kylie Klinkhammer, Roxana Wasnick, Cho-Ming Chao, Jie Yuan, Jin-San Zhang, Changfu Yao, Susan Majka, Barry R. Stripp, Andreas Günther, David W.H. Riches, Saverio Bellusci, Victor J. Thannickal, Stijn P. De Langhe   +16 more
doaj   +2 more sources

A Conformal Wearable Ultrasound Bioelectronics for Mechanotherapy Reprogramming of Fibroblast Plasticity via Wnt‐FGF10 Axis to Overcome Fibrotic Healing in Urethral Regeneration

Advanced Science
Postoperative fibrotic complications persistently challenge urethral reconstruction due to dysregulated stromal repair and poor graft integration.
Mingming Yu, Xingxuan Zhang, Huan Zhang, Jun Wang, Fang Chen, Xiaojun Cai, Yichen Huang, Yuanyi Zheng   +7 more
doaj   +2 more sources

Spatial Heterogeneity of FGFR2b in Gastric Cancer: A Comparative Analysis of Primary Tumors and Peritoneal Dissemination [PDF]

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin
Koichi Yagi, Tetsuo Ushiku, Yasuyuki Seto   +2 more
exaly   +2 more sources

Prevalence of FGFR2b Protein Overexpression in Advanced Gastric Cancers During Prescreening for the Phase III FORTITUDE-101 Trial. [PDF]

JCO Precis Oncol
PURPOSE: Fibroblast growth factor receptor 2 isoform IIIb (FGFR2b) protein overexpression is an emerging biomarker in gastric cancer and gastroesophageal junction cancer (GC).
Rha SY, Zhang Y, Elme A, Pazo Cid R, Alacacioglu A, Ziogas DC, Shitara K, Ranceva A, Nemecek R, Santoro A, Calderon CA, Korphaisarn K, Davis T, Zahlten-Kuemeli A, Conn C, Tan M, Honeycutt H, Wainberg ZA.   +17 more
europepmc   +4 more sources

Evidence for Overlapping and Distinct Biological Activities and Transcriptional Targets Triggered by Fibroblast Growth Factor Receptor 2b Signaling between Mid- and Early Pseudoglandular Stages of Mouse Lung Development

Cells, 2020
Branching morphogenesis is the basic developmental mode common to organs such as the lungs that undergo a process of ramification from a rudimentary tree.
Matthew R. Jones, Arun Lingampally, Jin Wu, Jamschid Sedighi, Negah Ahmadvand, Jochen Wilhelm, Ana Ivonne Vazquez-Armendariz, Susanne Herold, Chengshui Chen, Jin-San Zhang, Saverio Bellusci, Cho-Ming Chao   +11 more
doaj   +1 more source

Effect of Quercetin flavonoid on structural changes of recombinant human FGFR2b kinase domain

مجله دانشگاه علوم پزشکی بیرجند, 2017
Background and Aim: Antioxidants are compounds that protect cells from attacks of free radicals. Lack of balance between antioxidants and free radicals results in oxidative stress, which ultimately results in cell damage.
Benyamin Alimohammadi, Faezeh Seyyed-Attaran, Milad Vali-shirin, Hossein Piri   +3 more
doaj   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy. [PDF]

MedComm (2020)
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Song M, Liu X, Xiao Y, Li Y, Zhao H.
europepmc   +2 more sources

Bemarituzumab Is Active in FGFR2b-High Gastroesophageal Adenocarcinoma [PDF]

Cancer Discovery, 2020
Abstract The FGFR2b inhibitor bemarituzumab was effective in high-FGFR2b gastroesophageal adenocarcinoma.
openaire   +2 more sources

Advances in therapeutic approaches to gastric cancer. [PDF]

CA Cancer J Clin
Abstract Gastric cancer remains a leading cause of cancer‐related mortality worldwide, with nearly 1 million new cases diagnosed annually. Despite innovations in diagnosis, most patients still present at advanced stages, contributing to a poor prognosis.
Wang F, Wang ZX, Zhang YJ, He Y, Ji JF, Li YF, Qu XJ, Ba Y, Yuan SQ, Xu RH.   +9 more
europepmc   +2 more sources

Phenotypic spectrum of FGF10-related disorders: a systematic review [PDF]

PeerJ, 2022
FGF10, as an FGFR2b-specific ligand, plays a crucial role during cell proliferation, multi-organ development, and tissue injury repair. The developmental importance of FGF10 has been emphasized by the identification of FGF10 abnormalities in human ...
Katarzyna Bzdega, Justyna A. Karolak
doaj   +2 more sources