FGFR3 gene alteration and protein expression in upper urinary tract carcinoma: unsuitability of ureteroscopic biopsy specimens for FGFR3 RNA testing [PDF]
Exploration of Targeted Anti-tumor TherapyWe aimed to evaluate the suitability of archival ureteroscopic (URS) biopsy specimens for fibroblast growth factor receptor 3 (FGFR3) biomarker analysis in upper urinary tract urothelial carcinoma.
Makito Miyake +8 more
doaj +2 more sources
FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors [PDF]
The Journal of Clinical InvestigationFibroblast growth factor receptor 3 (FGFR3) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors.
Aura Moreno-Vega +32 more
doaj +2 more sources
EMBO Molecular Medicine, 2018 FGFR3 alterations (mutations or translocation) are among the most frequent genetic events in bladder carcinoma. They lead to an aberrant activation of FGFR3 signaling, conferring an oncogenic dependence, which we studied here.
Thierry Massfelder +2 more
exaly +2 more sources
Development of an extended version of GALEAS bladder: Detection of FGFR3 fusions in urine and associations between genomic alterations and gene expression [PDF]
Bladder CancerBackground The latest bladder cancer (BC) urine tests based on multiple genomic and/or epigenomic markers detect BC with high sensitivity and specificity.
Jessica L Neil +13 more
doaj +2 more sources
Clinical management and emerging therapies of FGFR3-related skeletal dysplasia in childhood [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2022 Skeletal dysplasia is a diverse group of disorders that affect bone development and morphology. Currently, approximately 461 different genetic skeletal disorders have been identified, with over 430 causative genes.
Hwa Young Kim, Jung Min Ko
doaj +1 more source
Journal of Biochemical and Clinical Genetics, 2022 Not available [JBCGenetics 2022; 5(2.000): 059-060]
Amsal Qureshi, Areesha Moiz Alvi
doaj +1 more source
Genetic variants of FGFR family associated with height, hypertension, and osteoporosis
Annals of Human Biology, 2023 Background Hypertension and osteoporosis are the most common types of health problems. A recent study suggested that the fibroblast growth factor receptor-like protein 1 (FGFRL1) gene in giraffes is the most promising candidate gene that may have direct ...
Hye-Won Cho, Hyun-Seok Jin, Yong-Bin Eom
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2023 Background Immune checkpoint blockade (ICB) therapy holds promise in metastatic urothelial carcinoma (UC). Fibroblast growth factor receptor 3 (FGFR3) mutation drives T-cell-depleted microenvironment in UC, which led to the hypothesis that FGFR3 mutation
Tao Xu +6 more
doaj +1 more source
Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage. [PDF]
PLoS ONE, 2008 Activating mutations in FGFR3 tyrosine kinase cause several forms of human skeletal dysplasia. Although the mechanisms of FGFR3 action in cartilage are not completely understood, it is believed that the STAT1 transcription factor plays a central role in ...
Pavel Krejci +8 more
doaj +1 more source
Balkan Journal of Medical Genetics, 2017 Variations Improper activation and inappropriate expression of fibroblast growth factor receptors (FGFRs) in cancer suggests that they can act as therapeutic targets.
Ousati Ashtiani Z +6 more
doaj +1 more source