Results 11 to 20 of about 24,353 (179)
K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]
Disease Models & Mechanisms, 2011 SUMMARY The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of
Imran Ahmad +8 more
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FGFR3 signaling and function in triple negative breast cancer [PDF]
Cell Communication and Signaling, 2020 Background Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options.
Nicole J. Chew +9 more
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Generation of Fgfr3 Conditional Knockout Mice
International Journal of Biological Sciences, 2010 Fibroblast growth factor receptor 3 (FGFR3), highly conserved in both humans and murine, is one of key tyrosine kinase receptors for FGF. FGFR3 is expressed in different tissues, including cartilage, brain, kidney, and intestine at different development ...
Nan Su, Xiaoling Xu, Cuiling Li, Qifen He, Ling Zhao, Can Li, Siyu Chen, Fengtao Luo, Lingxian Yi, Xiaolan Du, Haiyang Huang, Chuxia Deng, Lin Chen
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Роль мутационного статуса гена FGFR3 в предсказании прогрессирования рака мочевого пузыря без мышечной инвазии [PDF]
, 2015 A prospective study was conducted to assess the prognostic value of FGFR3 gene mutation status in patients with non-muscle invasive bladder cancer. A total of 265 patients were included in the study. FGFR3 gene mutations were found in 168 (63.4 %) cases.
R. I. Goncharova +7 more
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THE MOLECULAR PATHOGENESIS OF BLADDER CANCER
Alʹmanah Kliničeskoj Mediciny, 2016 The review describes the current views on urothelial carcinoma carcinogenesis. Based on the up-todate genetic studies, molecular pathways determining the development of superficial and invasive bladder cancers are considered. It was demonstrated that the
M. V. Nemtsova, N. E. Kushlinskii
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Frontiers in Pharmacology, 2021 Chemotherapeutic patients with leukemia often relapse and produce drug resistance due to the existence of leukemia stem cells (LSCs). Fibroblast growth factor receptor 3 (FGFR3) signaling mediates the drug resistance of LSCs in chronic myeloid leukemia ...
Chen Guo +9 more
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The Prognostic Value of FGFR3 Expression in Patients with T1 Non-Muscle Invasive Bladder Cancer
Cancer Management and Research, 2021 Danijel Sikic,1,2 Helge Taubert,1,2 Johannes Breyer,3 Markus Eckstein,2,4 Veronika Weyerer,2,4 Bastian Keck,1,2 Jennifer Kubon,1,2 Wolfgang Otto,3 Thomas S Worst,5 Maximilian C Kriegmair,5 Philipp Erben,5 Arndt Hartmann,2,4 Bernd Wullich,1,2 Ralph M ...
Sikic D +14 more
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BMC Musculoskeletal Disorders, 2023 Background Postmenopausal osteoporosis is a widespread health concern due to its prevalence among older adults and an associated high risk of fracture. The downregulation of bone regeneration delays fracture healing.
Itaru Kawashima +8 more
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FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases. [PDF]
, 2015 PURPOSE: FGFR3 is considered a good therapeutic target for bladder cancer. However, to our knowledge it is unknown whether the FGFR3 status of primary tumors is a surrogate for related metastases, which must be targeted by FGFR targeted systemic ...
Achim Fleischmann +23 more
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Romanian Journal of Laboratory Medicine, 2018 Molecular genetic testing in craniosynostosis leads to the detection of the mutations in the genes encoding fibroblast growth factor receptors (FGFR), providing information about the etiology of the genetic disorder.
Bogliş Alina +2 more
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