Results 41 to 50 of about 24,353 (179)

A WGCNA‐Based Approach to Identify Hub Genes Associated With TNM Staging in Urothelial Bladder Carcinoma

Cancer Nexus, EarlyView.
ABSTRACT In this study, we identified gene modules and representative candidate biomarkers linked to clinical progression in patients with UBC. Weighted gene co‐expression network analysis (WGCNA) was used to identify gene modules associated with TNM staging in UBC patients.
Arshia Azmoudeh
wiley   +1 more source

FGFR3 expression patterns in HEK 293 cells.

, 2013
Cells were transfected with 2 µg/well of DNA encoding FGFR3/WT, FGFR3/G346E, or FGFR3/G375C. 24 hours after transfection, cells were starved in serum-free medium, followed by cell lysis.
Lijuan He (234034), Nitish Niphadkar (325880), Kalina Hristova (303684), Christopher Serrano (325878), Nadia Shobnam (325881)   +4 more
core   +1 more source

Mutation analysis of the fibroblast growth factor receptor 3 gene in fetuses with thanatophoric dysplasia, type I

Clinical and Experimental Obstetrics & Gynecology, 2020
Objective: To analyze the fibroblast growth factor receptor 3 gene (FGFR3) mutations in fetuses with thanatophoric dysplasia type I (TD1) and to provide additional data for genotype-phenotype analyses.
Q.C. Wu, W.B. Wang, L. Sun, Y.S. Xu, X.J. Xie, X.M. Ma, Z.Y. Su   +6 more
doaj   +1 more source

Clinical, Radiologic and Cytologic Predictors of Malignancy in Pediatric Thyroid Nodules: Insights From a 26‐Year Cohort Study

Head &Neck, EarlyView.
ABSTRACT Introduction Thyroid nodules are less common but more often malignant in pediatric patients than in adults. Our objectives were to study the features of benign vs. malignant thyroid nodules in a large pediatric patient cohort. Methods Retrospective observational cohort study. Consecutive patients aged 0.01–17.9 years at evaluation between 1997–
Maxime Gest‐Laurent, Adrien Nguyen Quoc, Christine Lefevre, Laura González‐Briceño, Caroline Thalassinos, Isabelle Flechtner, Dulanjalee Kariyawasam, Yamina Dassa, Magali Viaud, Dinane Samara‐Boustani, Graziella Pinto, Hervé Monpeyssen, Sabine Sarnacki, Vincent Couloigner, Michel Polak, Athanasia Stoupa   +15 more
wiley   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

STAT5 activation by FGFR3 mutants.

, 2013
RCS chondrocytes transfected with vectors expressing wild-type FGFR3, activating FGFR3 mutants (N540K, G380R, R248C, Y373C, K650M and K650E), and kinase-inactive mutant K508M were grown for 24 hours and analyzed for the indicated molecules by western ...
Katarina Chlebova (375466), Leslie Michels Thompson (375468), Vitezslav Bryja (167936), Tamara A. Kashiwada (375465), Alois Kozubik (167927), Alena Salasova (375467), Pavel Krejci (167835), Lisa Salazar (167940), William R. Wilcox (167921)   +8 more
core   +1 more source

FGFR3 has tumor suppressor properties in cells with epithelial phenotype. [PDF]

, 2013
International audienceBACKGROUND: Due to frequent mutations in certain cancers, FGFR3 gene is considered as an oncogene. However, in some normal tissues, FGFR3 can limit cell growth and promote cell differentiation. Thus, FGFR3 action appears paradoxical.
Moreau-Gaudry, François, Marie Lafitte, de Verneuil, Hubert, Dabernat, Sandrine, Sandrine Dabernat, Garcia, Stéphane, Bedel, Aurélie, Rousseau, Benoit, Dubus, Pierre, Stéphane Garcia, François Moreau-Gaudry, Isabelle Moranvillier, Iovanna, Juan, Benoit Rousseau, Geneviève Belleannée, Guyonnet-Dupérat, Véronique, Aurélie Bedel, Pierre Dubus, Hubert de Verneuil, Ramos, Jeanne, Véronique Guyonnet-Dupérat, Belleannée, Geneviève, Lafitte, Marie, Jeanne Ramos, Moranvillier, Isabelle, Evelyne Peuchant, Juan Iovanna, Peuchant, Evelyne   +27 more
core   +1 more source

Clinical Utility of Nuchal Translucency Measurement in First‐Trimester Ultrasound Screening in a Setting With First‐Tier NIPT for Aneuploidy Screening

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To investigate the additional clinical value of nuchal translucency (NT) measurement at the first‐trimester anomaly scan (FTAS) in a setting with first‐tier non‐invasive prenatal testing (NIPT). Method This nationwide prospective cohort study, part of the IMITAS study on FTAS implementation, included all pregnancies with increased NT
Eline E. R. Lust, Kim Bronsgeest, Lidewij Henneman, Neeltje M. T. H. Crombag, Caterina M. Bilardo, Robert‐Jan H. Galjaard, Esther Sikkel, Audrey B. C. Coumans, Ayten Elvan‐Taşpınar, Sander Galjaard, Attie T. J. I. Go, Gwendolyn T. R. Manten, Eva Pajkrt, Elisabeth van Leeuwen, Monique C. Haak, Mireille N. Bekker   +15 more
wiley   +1 more source

R248C-FGFR3-Mutation

, 2010
Activating FGFR3 mutations have been identified in a variety of benign skin lesions (seborrheic keratosis, epidermal nevus, solar lentigo). However, the functional consequences of these mutations in the human epidermis are unknown.
A. Hartmann, Hafner, C., C. Hafner, Hartmann, A.   +3 more
core   +1 more source

Genetic Investigation in Fetal Growth Restriction: An Integrated Approach for Clinical Practice

Prenatal Diagnosis, EarlyView.
ABSTRACT International guidelines recommend genetic testing when fetal growth restriction (FGR) accompanies structural anomalies, but recommendations for apparently isolated FGR remain variable, particularly regarding gestational age thresholds and the role of exome sequencing (ES). Interpretation is difficult because studies define FGR inconsistently,
Eran Ashwal, David Chitayat
wiley   +1 more source