Results 51 to 60 of about 24,353 (179)

Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia. [PDF]

PLoS ONE, 2013
Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug
Masaki Matsushita, Hiroshi Kitoh, Bisei Ohkawara, Kenichi Mishima, Hiroshi Kaneko, Mikako Ito, Akio Masuda, Naoki Ishiguro, Kinji Ohno   +8 more
doaj   +1 more source

Cryopreservation Disrupts TRIM21‐Mediated AKAP3 Ubiquitination and Triggers Stress Granule Formation in Human Sperm

Andrology, EarlyView.
ABSTRACT Background Sperm cryopreservation causes cryodamage, but the roles of posttranslational modifications (PTMs) and stress granules (SGs) in this process remain unclear. Objectives To investigate the molecular mechanism of cryodamage via the TRIM21–AKAP3 axis, PTMs, and SGs.
Yan Wang, Huizhong Xu, Wenhong Lu, Yinghao Wang, Jin Ma, Chengyao Ma, Xiangming Yan, Longlong Fu, Haitao Lv, Ying Liu   +9 more
wiley   +1 more source

Fgfr3 regulates development of the caudal telencephalon [PDF]

, 2011
The fibroblast growth factor receptor 3 (Fgfr3) is expressed in a rostral(low) to caudal(high) gradient in the developing cerebral cortex. Therefore, we hypothesized that Fgfr3 contributes to the correct morphology and connectivity of the caudal cortex ...
Holmes, W.M., Moldrich, Randal X., Iwata, T., Rankin, Alastair J., Kurniawan, Nyoman, Richards, Linda J., Barr, Emily, Sailaja Goda, Linda J. Richards, Guillermina López-Bendito, Moldrich, R.X., Kurniawan, N., William M. Holmes, Holmes, William M., Emily Barr, Deborah Dewar, Brookfield, Sam J., Nyoman Kurniawan, Goda, Sailaja, López-Bendito, G., Randal X. Moldrich, Rankin, A.J., Mezzera, C., Goda, S., Brookfield, S.J., Tomoko Iwata, Alastair J. Rankin, Dewar, D., Barr, E., Mezzera, Cecilia, Cecilia Mezzera, Richards, L.J., López-Bendito, Guillermina, Sam J. Brookfield, Iwata, Tomoko, Dewar, Deborah   +35 more
core   +1 more source

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration

Stem Cell Research & Therapy, 2022
Background Intervertebral disc degeneration (IVDD) can cause low back pain, a major public health concern. IVDD is characterized with loss of cells especially those in nucleus pulposus (NP), due to the limited proliferative potential and regenerative ...
Meng Xu, Junlan Huang, Min Jin, Wanling Jiang, Fengtao Luo, Qiaoyan Tan, Ruobin Zhang, Xiaoqing Luo, Liang Kuang, Dali Zhang, Sen Liang, Huabing Qi, Hangang Chen, Zhenhong Ni, Nan Su, Jing Yang, Xiaolan Du, Bo Chen, Chuxia Deng, Yangli Xie, Lin Chen   +20 more
doaj   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

drbergman/FGFR3-BladderCancer-ABM: Final release before re-submit

<p>Release ready for re-submit.</p> <p><strong>Full Changelog</strong>: https://github.com/drbergman/FGFR3-BladderCancer-ABM/commits/v1.0.0-beta</p ...
Daniel Bergman
core   +1 more source

Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting

Brain Pathology, EarlyView.
Using the Infinium MethylationEPIC v2.0 array and Heidelberg Brain Tumor Classifier v12.8, 24 international laboratories achieved highly reproducible CNS tumor classification (97.9% correct; median β‐correlation r = 0.99), while copy number variation interpretation showed substantial interlaboratory variability, highlighting the need for harmonized CNV
Katrin Mauch‐Mücke, Christin Siewert, Lora Dimitrova, Sandra Pohl, Brendan Osberg, Annika K. Wefers, Julia Lorenz, Tanja Rothhammer‐Hampl, Till Acker, Alonso Barrantes‐Freer, Jean Boutonnat, Bérengère Dadone‐Montaudié, Claire Delbridge, Wolfgang Dietmaier, Sebastian Dintner, Hildegard Dohmen, Matthias Dottermusch, Daniel Erny, Katrin B. M. Frauenknecht, Tobias Goschzik, Patrick N. Harter, Daniela Hirsch, Yanghao Hou, Theo F. J. Kraus, Maggie Lee, Friederike Liesche‐Starnecker, Anne Mc Leer, Linea Melchior, Michael Mittelbronn, Wolf C. Müller, Shalima S. Nair, Julia E. Neumann, Pitt Niehusmann, Nicole Pfarr, Torsten Pietsch, Marco Prinz, Markus Rechsteiner, Regina Reimann, Laveniya Satgunaseelan, Veronica Skarpeteig, Anne J. Skjulsvik, Karl Sotlar, Isabelle Vanden Bempt, Erik Vassella, Katharina J. Weber, Gabriel Wasinger, Andreas Waha, Karen Zwaenepoel, Felix Sahm, Markus J. Riemenschneider, David Capper   +50 more
wiley   +1 more source

Molecular Analysis of a Case of Thanatophoric Dysplasia Reveals Two de novo FGFR3 Missense Mutations located in cis

Sultan Qaboos University Medical Journal, 2013
Objectives: Thanatophoric dysplasia (TD) is the most common form of lethal skeletal dysplasia. It is primarily an autosomal dominant disorder and is characterised by macrocephaly, a narrow thorax, short ribs, brachydactyly, and hypotonia.
Renate Marquis-Nicholson, Salim Aftimos, Donald R. Love   +2 more
doaj  

Fibroblast Growth Factor Receptor 3 Mutation as a Prognostic Indicator in Patients with Urothelial Carcinoma: A Systematic Review and Meta-analysis

European Urology Open Science, 2020
Background: Fibroblast growth factor receptor 3 (FGFR3) mutations have been implicated in urothelial tumorigenesis. FGFR3 inhibitors are being explored in clinical trials.
Sidra Khalid, Bassam Mohammed Basulaiman, Jeffrey Emack, Christopher M. Booth, Ignacio Duran, Andrew G. Robinson, David Berman, Martin Smoragiewicz, Eitan Amir, Francisco E. Vera-Badillo   +9 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source