Results 61 to 70 of about 24,353 (179)
Effect of the achondroplasia mutations on FGFR3 phosphorylation.
, 2013 HEK 293 cells were transfected with plasmids encoding FGFR3/WT, FGFR3/G346E and FGFR3/G375C. Different concentrations of fgf1, ranging from 50 to 2500 ng/ml, were added to the serum-free medium.
Lijuan He (234034) +4 more
core +1 more source
ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer
Scientific Reports, 2019 Activating mutations of fibroblast growth factor receptor 3 (FGFR3) are common in urothelial carcinoma of the bladder (UC). Silencing or inhibition of mutant FGFR3 in bladder cancer cell lines is associated with decreased malignant potential, confirming ...
Erica di Martino +3 more
doaj +1 more source
BMC Cancer, 2017 Background Fibroblast growth factor receptors (FGFRs) are well-known proto-oncogenes in several human malignancies and are currently therapeutically targeted in clinical trials.
Birgitta Lehtinen +10 more
doaj +1 more source
JCI Insight, 2023 Overactive fibroblast growth factor receptor 3 (FGFR3) signaling drives pathogenesis in a variety of cancers and a spectrum of short-limbed bone dysplasias, including the most common form of human dwarfism, achondroplasia (ACH).
Yun-Wen Lin +6 more
doaj +1 more source
Integrated Analysis of HER2 Expression and ERBB2 Alterations in Bladder Cancer
Cancer Science, EarlyView.Integrated analysis of 445 bladder cancers showed that HER2 membrane expression and ERBB2 amplification are distinct features. HER2 expression overlapped with NECTIN4 expression, whereas ERBB2 amplification was enriched in the LumU subtype and associated with poor prognosis.
Kensuke Hirosuna +13 more
wiley +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source
FGFR3 signal transduction in chondrocytes and mechanisms of FGFR3 inhibitors.
, 2013 Activations of MAPK (mitogen-activated protein kinase) and STAT (signal transducers and activators of transcription) negatively regulate chondrocyte proliferation and differentiation.
Kenichi Mishima (124276) +8 more
core +1 more source
Functional Characterization of Oncogenic Driver FGFR3-TACC3 [PDF]
, 2018 Fibroblast Growth Factor Receptors (FGFRs) are critical for cell proliferation and differentiation. Mutation and/or translocation of FGFRs lead to aberrant signaling that often results in developmental syndromes or cancer growth.
Nelson, Katelyn
core +1 more source
Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy
Advanced ScienceSensory neuronopathies (SNN) and small fiber neuropathies (SFN) are debilitating disorders associated with neuropathic pain, yet their underlying mechanisms remain poorly understood.
Lyuba Y. Salih +12 more
doaj +1 more source
Neurodevelopmental and neurological features in children with hypochondroplasia
Developmental Medicine &Child Neurology, EarlyView.Abstract Aim To assess neurodevelopmental and neurological features, including neuroimaging abnormalities, in children with molecularly confirmed hypochondroplasia. Method A retrospective cohort study of children with molecularly confirmed hypochondroplasia seen at Evelina London Children's Hospital skeletal dysplasia service was performed.
Megan F. Baxter +3 more
wiley +1 more source