Results 81 to 90 of about 24,353 (179)

UV signature mutation hyperhotspots as genomic dosimeters

Photochemistry and Photobiology, EarlyView.
Recurrent UV signature mutations are a sensitive and specific indicator of sun exposure. UV signature mutations (C → T mutations at dipyrimidine sites) were quantified using Duplex Sequencing and a stringent mutation calling protocol to identify true low‐abundance mutations.
Vijay Menon, Alejandro García‐Ruiz, Susan Neveu, Brenda Cartmel, Leah M. Ferrucci, Meg Palmatier, Christine Ko, Kenneth Y. Tsai, Mio Nakamura, Sa Rang Kim, Michael Girardi, Karl Kornacker, Douglas E. Brash   +12 more
wiley   +1 more source

Refining risk stratification after indeterminate urinary cytology: Evidence from Bladder EpiCheck

Cancer Cytopathology, Volume 134, Issue 10, October 2026.
Abstract Background This study aimed to evaluate Bladder EpiCheck (BE) performance in detecting urothelial carcinoma (UC) and HG (high‐grade) events in patients with indeterminate cytology and negative cystoscopy. Methods This prospective study included 63 patients who presented with indeterminate urinary cytology and negative cystoscopy between ...
Claudia Mercader, Mercedes Ingelmo‐Torres, Fiorella L. Roldán, Marcel Figueras, Eric Villalba, Pilar Galve, Ignacio Asiaín, Meritxell Costa, Antoni Vilaseca, Josep Oriola, Agustín Franco, Antonio Alcaraz, Lourdes Mengual   +12 more
wiley   +1 more source

FGFR3 mutation and FGFR3-TACC3 fusion status.

, 2016
(A) The heatmap shows the distribution of FGFR3 mutations and FGFR3-TACC3 fusions with respect to T stage and pathological grade. (B) Subgroup analysis of NMIBC by T stage.
Hiroshi Tsuruta (3387065), Masahiro Kurobe (3387050), Mikio Sugimoto (3387062), Yuichi Iizumi (3387056), Hiroyuki Nishiyama (105359), Takahiro Kojima (2327002), Takayuki Yoshino (616028), Yoshiyuki Kakehi (567218), Tomonori Habuchi (95713), Yoshiyuki Nagumo (3387047), Kouichi Nishimura (3387059), Shuya Kandori (3387068), Takashi Kobayashi (153394), Yoshiyuki Matsui (2211958), Osamu Ogawa (95712), Satoshi Ueno (731209), Takashi Kawahara (294168), Koji Mitsuzuka (3387053), Koji Kikuchi (267453), Yoichi Arai (728069), Masakazu Tsutsumi (3387071), Takehiro Oikawa (3387044)   +21 more
core   +1 more source

The FGFR3 mutation is related to favorable pT1 bladder cancer

, 2012
Purpose: Stage pT1 bladder cancer comprises a heterogeneous group of tumors for which different management options are advocated. FGFR3 mutations are linked to favorable (low grade/stage) pTa bladder cancer while altered P53 is common in cases of high ...
Zlotta, Alexandre R., Alkhateeb, Sultan S., Jewett, Michael A.S., Bapat, Bharati, Van Rhijn, Bas W.G., Van Der Kwast, Theo H., Bangma, Chris H., Fleshner, Neil E., Liu, Liyang, Bostrom, Peter J., Vis, André N., Zwarthoff, Ellen C.   +11 more
core   +2 more sources

Craniofacial Morphology and Dental Age Assessment in Pediatric Craniosynostosis: A Comparative Cross‐Sectional Study

Clinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objectives To delineate the craniofacial morphometric characteristics of Thai children with syndromic (SC) and non‐syndromic craniosynostosis (NSC) and to assess dental maturation relative to Chronological Age (CA). Methods This comparative cross‐sectional study evaluated 19 patients (SC: n = 13; NSC: n = 6; mean age 9.32 ± 2.67 years ...
Nutthakarn Ratanasereeprasert, Yanisa Wongbanthit, Narin Intarak, Preeya Suwanwitid, Chutimont Teekavanich, Anand Marya, Guang Hong, Thantrira Porntaveetus   +7 more
wiley   +1 more source

Caractérisation des voies de signalisation des oncogènes FGFR3 muté et FGFR3-TACC3 dans les carcinomes de vessie

, 2015
Bladder cancer progression can be divided in two main pathways. The pathway of In Situ Carcinoma (CIS) which progress through an invasion of the basement membrane and then the muscle and the pathway of Ta papillary tumors which change little but recur ...
Mahé, Mélanie
core   +1 more source

Prenatal exome sequencing of fetuses with central nervous system anomalies based on prenatal ultrasound and magnetic resonance imaging diagnosis: A retrospective cohort study with a systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1950-1964, October 2026.
Prenatal exome sequencing significantly improves diagnostic yield over chromosomal microarray analysis for fetal CNS abnormalities, with a diagnostic yield of 16% in our cohort and 27% in the meta‐analysis. Diagnostic yields vary across different phenotypes. Abstract Introduction Fetal central nervous system (CNS) abnormalities have diverse etiologies,
Jia Yao, Yan Wang, Gang Li, Zhitao Zhang, Yuan Lv, Lizhu Chen   +5 more
wiley   +1 more source

Characterization of the Mutated FGFR3 and FGFR3-TACC3 Receptor Signaling Pathways in Bladder Carcinoma

, 2015
Les tumeurs de vessie suivent deux voies de progression tumorale. La voie des carcinomes in situ (CIS) qui progressent pour envahir la membrane basale puis le muscle, et la voie des tumeurs papillaires de bas grade qui progressent peu mais qui récidivent
Mahé, Mélanie
core  

The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor‐αKlotho Complex Increases Sinoatrial Electrical Activity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Giorgia Bertoli, Patrizia Benzoni, Serena Canzolino, David Molla, Raffaella Milanesi, Chiara Piantoni, Makoto Kuro‐o, Carmen Delgado, Gema Ruiz‐Hurtado, Mirko Baruscotti, Annalisa Bucchi   +10 more
wiley   +1 more source

Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT The differentiation between benign and malignant biliary strictures remains a significant clinical challenge. Recent studies have suggested that next generation sequencing (NGS) can improve the diagnostic accuracy. However, evidence on its performance in routine clinical practice is limited. Therefore, validation of the diagnostic value of NGS
Antonia Gillmeister, Julia Husman, Renate Schmelz, Stefan Brückner, Jochen Hampe, Daniela Aust, Sebastian Zeissig   +6 more
wiley   +1 more source