Results 91 to 100 of about 24,353 (179)

Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling. [PDF]

, 2011
Endocytosis of tyrosine kinase receptors can influence both the duration and the specificity of the signal emitted. We have investigated the mechanisms of internalization of fibroblast growth factor receptor 3 (FGFR3) and compared it to that of FGFR1 ...
Brech Andreas, Andreas Brech, Zakrzewska Malgorzata, Olsnes Sjur, Haugsten Ellen Margrethe, Sjur Olsnes, Sascha Pust, Jørgen Wesche, Pust Sascha, Ellen Margrethe Haugsten, Kirsten Sandvig, Malgorzata Zakrzewska, Sandvig Kirsten, Wesche Jørgen   +13 more
core   +1 more source

Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats

Experimental Physiology, Volume 111, Issue 10, Page 4578-4619, 1 October 2026.
Abstract Loss of ovarian hormones (i.e., menopause) leads to negative effects on metabolic health. While exercise offers significant benefits, it seems to be insufficient to completely reverse these changes. The mechanisms by which exercise conveys the effects throughout the body are still poorly understood.
Veera Puumalainen, Anni Maja, Tia‐Marje Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira Karvinen   +7 more
wiley   +1 more source

Novel therapeutic strategy for cervical cancer harboring FGFR3-TACC3 fusions.

, 2018
We previously found that therapeutic targetable fusions are detected across various cancers. To identify therapeutic targetable fusion in uterine cervical cancer, for which no effective gene targeted therapy has yet been clinically applied, we analyzed ...
Aoki, Yoichi, Motoyama, Teiichi, Juan Emmanuel Martínez-Ledesma, Okuda, Shujiro, Hiroaki Itamochi, Hirofumi Nakaoka, Ryosuke Ishimura, Teiichi Motoyama, Enomoto, Takayuki, Seiya Sato, Verhaak, Roel G W, Saito, Tetsuya, Masaaki Komatsu, Mori, Yutaro, Yutaro Mori, Yoichi Aoki, Sato, Seiya, Cristine R. Casingal, Kosuke Yoshihara, Shujiro Okuda, Itamochi, Hiroaki, Hu Xin, Yamawaki, Kaoru, Tatsuya Ishiguro, Tamura, Ryo, Ishimura, Ryosuke, Martínez-Ledesma, Juan Emmanuel, Yoshihara, Kosuke, Casingal, Cristine R, Kazuaki Suda, Xin, Hu, Takayuki Enomoto, Inoue, Ituro, Ituro Inoue, Ryo Tamura, Kaoru Yamawaki, Roel G. W. Verhaak, Ishiguro, Tatsuya, Nakaoka, Hirofumi, Komatsu, Masaaki, Tetsuya Saito, Suda, Kazuaki   +41 more
core   +1 more source

FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes

, 2010
FGFR3 mutations have recently been identified in several benign epidermal skin lesions such as seborrheic keratosis, epidermal nevus and solar lentigo.
Hartmann, Arndt, Knowles, Margaret, Stempfl, Thomas, Tomlinson, Darren, Landthaler, Michael, Hafner, Christian, Vogt, Thomas, Di Martino, Erica, Pitt, Eva   +8 more
core   +1 more source

Hypochondroplasia: An underrecognized neurodevelopmental disorder

Developmental Medicine &Child Neurology, EarlyView.
Janet M. Legare
wiley   +1 more source

Tumor Heterogeneity of Fibroblast Growth Factor Receptor 3 (FGFR3) Mutations in Invasive Bladder Cancer: Implications for Peri-Operative anti-FGFR3 Treatment [PDF]

, 2016
Background: Fibroblast growth factor receptor 3 (FGFR3) is an actionable target in bladder cancer. Preclinical studies show that anti-FGFR3 treatment slows down tumor growth, suggesting that this tyrosine kinase receptor is a candidate for personalized ...
Houede, N, Houédé, N., Mertens, L.S., Hoernblas, S, Peters, D, de Jong, J., Mertens, L. S., Moktefi, A, Zlotta, AR, van der Heijden, MS, Maille, P, Leroy, K., Maille, P., Mertens, LS, de Jong, J, Knowles, M. A., Sanders, J, Semprez, F, Tomlinson, D. C., Vordos, D, Beuzeboc, P, Jewett, M. A. S., Neuzillet, Y, Bapat, B, Allory, Y., Jewett, M.A., Hurst, C., Bostrom, P. J., Peters, D., Bapat, B., Tomlinson, DC, Zlotta, A. R., Harnden, P, Manceau, A., Vordos, D., Lotan, Y, Hurst, CD, van Rhijn, BWG, van Der Kwast, T., Jewett, MAS, Burger, M, Pouessel, D, Culine, S, van Rhijn, B., Sanders, J., van der Heijden, M. S., Manceau, A, Neuzillet, Y., Hurst, C. D., Bostrom, P., Mirtti, T., Chevreau, C., Knowles, M., Broeks, A., van Der Heijden, M.S., van der Kwast, TH, Beuzeboc, P., Sagalowsky, A., van der Kwast, T. H., Burger, M., Moktefi, A., Knowles, MA, Leroy, K, Horenblas, S., Pouessel, D., van Rhijn, B. W. G., Shariat, SF, Harnden, P., Zlotta, A., de la Taille, A, Loriot, Y., Soyeux, P., Bostrom, PJ, Lotan, Y., Sagalowsky, A. I., Broeks, A, Culine, S., Mirtti, T, Sagalowsky, AI, Soyeux, P, Chevreau, C, de La Taille, A., Ashfaq, R, Shariat, S. F., Tomlinson, D.C., Shariat, S.F., Semprez, F., Ashfaq, R., Loriot, Y   +88 more
core   +1 more source

FGFR3 drives Aβ-induced tau uptake

The amyloid cascade hypothesis suggests that amyloid beta (Aβ) contributes to initiating subsequent tau pathology in Alzheimer’s disease (AD). However, the underlying mechanisms through which Aβ contributes to tau uptake and propagation remain poorly ...
Inhee Mook-Jung, Sunghoe Chang, Youngsoo Kim, Kyujin Suh, Sang-Eun Lee, Jihui Han, Junho Park, Dong Kyu Kim   +7 more
core   +1 more source

Fibroblastikasvutekijäreseptorin inhibointi FGFR3:TACC3 fuusio positiivisissa glioblastoma soluissa [PDF]

, 2017
Glioblastoma multiforme is the most common of adult primary brain tumors. It is a highly aggressive form of diffuse gliomas and with current treatments median life expectancy of patients with glioblastoma is approximately 14 months.
Mäntylä, Sonja Christina
core  

Spectrum of FGFR3 Mutations in Multiple Intraindividual Seborrheic Keratoses

, 2007
Somatic FGFR3 mutations have recently been identified in seborrheic keratoses (SK). Affected individuals often show a large number of SK, but their spectrum of FGFR3 mutations has not been investigated yet.
Hartmann, Arndt, Landthaler, Michael, Hofstaedter, Ferdinand, Hafner, Christian, Real, Francisco X., Vogt, Thomas   +5 more
core   +1 more source

RUNX2 is essential for maintaining synchondrosis chondrocytes and cranial base growth

Bone Research
The cranial base synchondroses, comprised of opposite-facing bidirectional chondrocyte layers, drive anteroposterior cranial base growth. In humans, RUNX2 haploinsufficiency causes cleidocranial dysplasia associated with deficient midfacial growth ...
Shawn A. Hallett, Ashley Dixon, Isabella Marrale, Lena Batoon, José Brenes, Annabelle Zhou, Ariel Arbiv, Vesa Kaartinen, Benjamin Allen, Wanida Ono, Renny T. Franceschi, Noriaki Ono   +11 more
doaj   +1 more source