Results 71 to 80 of about 24,353 (179)
Clinical characterisation of sensory neuropathy with anti-FGFR3 autoantibodies
Objective. Sensory neuropathies (SNs) are often classified as idiopathic even if immunological mechanisms can be suspected. Antibodies against the intracellular domain of the fibroblast growth factor receptor 3 (FGFR3) possibly identify a subgroup of SN ...
Reynaud-Federspiel, Evelyne +11 more
core +1 more source
Journal of Immunology Research, 2018 Our previous studies showed that Fibroblast growth factor receptor 3 (FGFR3) contributed to cell growth in lung cancer. However, the correlation between FGFR3 and tumor progression, coupled with the underlying mechanisms, are not fully understood.
Pengyu Jing +9 more
doaj +1 more source
Genetic testing in paediatric neurological disorders
Developmental Medicine &Child Neurology, EarlyView.In this study 390 paediatric patients with neurological disorders underwent genetic testing via exome sequencing, commercial panel, in‐house epilepsy, and movement disorder gene panels. Exome sequencing provides the highest diagnostic yield, and severe developmental delay and hypotonia predicted pathogenic variants in the exome sequencing cohort ...
Wafa Bani Uraba +15 more
wiley +1 more source
, 2009 Objectives: The fibroblast growth factor receptor 3 gene ( FGFR3) plays a critical role in cartilage growth-plate differentiation and bony development.
Hung, Chia-Cheng; Lee, Chien-Nan; Chang, Chien-Hui; Jong, Yuh-Jyh; Chen, Chih-Ping; Hsieh, Wu-Shiun; Su, Yi-Ning; Lin, Win-Li +1 more
core
FGFR3 Mutations in Benign Skin Tumors
, 2006 Activating FGFR3 germline mutations cause skeletal dysplasia and craniosynostosis syndromes. Somatic FGFR3 mutations have been identified in several cancer entities such as urothelial carcinoma and multiple myeloma.
Thomas Vogt +5 more
core +1 more source
FGFR3-TACCs3 Fusions and Their Clinical Relevance in Human Glioblastoma
, 2022 Oncogenic fusion genes have emerged as successful targets in several malignancies, such as chronic myeloid leukemia and lung cancer. Fusion of the fibroblast growth receptor 3 and the transforming acidic coiled coil containing protein—FGFR3-TACC3 fusion ...
Hanna Gött +3 more
core +1 more source
Disease Models & Mechanisms, 2016 Activating mutations in fibroblast growth factor receptor 3 (FGFR3) have been identified in multiple types of human cancer and in congenital birth defects.
Yongjun Yin +12 more
doaj +1 more source
, 2012 John M Millholland, Shuqiang Li, Cecilia A Fernandez, Anthony P ShuberPredictive Biosciences Inc, Lexington, MA, USAAbstract: Biological fluid-based noninvasive biomarker assays for monitoring and diagnosing disease are clinically powerful.
Shuber AP +4 more
core
FGFR3 can tyrosine phosphorylate TAK1.
, 2014 (A) HEK293 cells transfected with FGFR3K508M or FGFR3K650E. Twenty-four hours following transfection, cells were lysed and TAK1 immunoprecipitated from 1 mg total lysate.
Matthew Hallowell (513742) +8 more
core +1 more source
Histopathology, EarlyView.Hybrid grading systems significantly improve progression‐risk stratification in non‐invasive papillary urothelial carcinoma compared with the WHO 2004/2016 binary classification, with most benefit achieved by a Hybrid 3‐Tier framework. These findings support the existence of a histomorphological continuum of progression risk within the conventional ...
Jane K Nguyen +16 more
wiley +1 more source