Results 21 to 30 of about 24,353 (179)

Development of RNA-FISH Assay for Detection of Oncogenic FGFR3-TACC3 Fusion Genes in FFPE Samples. [PDF]

PLoS ONE, 2016
Oncogenic FGFR3-TACC3 fusions and FGFR3 mutations are target candidates for small molecule inhibitors in bladder cancer (BC). Because FGFR3 and TACC3 genes are located very closely on chromosome 4p16.3, detection of the fusion by DNA-FISH (fluorescent in
Masahiro Kurobe, Takahiro Kojima, Kouichi Nishimura, Shuya Kandori, Takashi Kawahara, Takayuki Yoshino, Satoshi Ueno, Yuichi Iizumi, Koji Mitsuzuka, Yoichi Arai, Hiroshi Tsuruta, Tomonori Habuchi, Takashi Kobayashi, Yoshiyuki Matsui, Osamu Ogawa, Mikio Sugimoto, Yoshiyuki Kakehi, Yoshiyuki Nagumo, Masakazu Tsutsumi, Takehiro Oikawa, Koji Kikuchi, Hiroyuki Nishiyama   +21 more
doaj   +1 more source

FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?†

, 2020
Fibroblast growth factor receptor 3 (FGFR3) is an actionable target in bladder cancer (BC). FGFR3 mutations are common in noninvasive BC and associated with favorable BC prognosis.
van Rhijn, Bas W. G., Neuzillet, Yann, Malats, N. ria, Jewett, Michael A.S., Real, Francisco X., Roshani, Hossain, Mertens, Laura S., Bertz, Simone, Sirab, Nanor, Zwarthoff, Ellen C., Jewett, Michael A. S., van Leenders, Geert J. L. H., Broeks, Annegien, Burger, Maximilian, Hippe, Katrin, Mayr, Roman, Eckstein, Markus, van der Kwast, Theo H., Boormans, Joost L., Wullich, Bernd, Malats, Núria, van der Heijden, Michiel S., Hartmann, Arndt, Otto, Wolfgang, van Rhijn, Bas W.G., Sanders, Joyce, Abas, Cheno, Marquez, Mirari, Radvanyi, François, Allory, Yves, Zlotta, Alexandre R., Zuiverloon, Tahlita C.M., van Leenders, Geert J.L.H., Zuiverloon, Tahlita C. M., Götz, Stefanie, Pouessel, Damien, Stoehr, Robert, Bostrom, Peter J., Soorojebally, Yanish   +38 more
core   +1 more source

Fibroblast Growth Factor Receptor 3 (FGFR3) Gene Amplification in Patients with Urothelial Carcinoma of the Urinary Bladder

The Iraqi Journal of Medical Sciences, 2021
Background: The fibroblast growth factor receptors (FGFRs) family includes five tyrosine kinase receptors, which play an important role in many cellular mechanisms including proliferation, migration and survival.
Mohsin Al-Marashi, Ban Qasim
doaj   +5 more sources

Direct assessment of the effect of the Gly380Arg achondroplasia mutation on FGFR3 dimerization using quantitative imaging FRET. [PDF]

PLoS ONE, 2012
The Gly380Arg mutation in FGFR3 is the genetic cause for achondroplasia (ACH), the most common form of human dwarfism. The mutation has been proposed to increase FGFR3 dimerization, but the dimerization propensities of wild-type and mutant FGFR3 have not
Jesse Placone, Kalina Hristova
doaj   +1 more source

The Role of FGFR3 in Skeletal Repair [PDF]

, 2016
Fibroblast growth factor receptor 3 (FGFR3) mutations cause skeletal dysplasias with disparate phenotypes. Gain-of-function mutations are characterized by disproportionate short stature, whereas loss-of-function mutations are characterized by tall ...
Kelley, Simon Paul
core   +2 more sources

Circ_0061825 Acts as a miR-593-3p Sponge to Promote Breast Cancer Progression by Regulating FGFR3 Expression

Cancer Management and Research, 2020
Jiping Xie, Yi Wan, Min Zhang, Zeyu Jin, Yongqiang Yao Third Ward of Breast and Thyoid Surgery Department, Affiliated Zhongshan Hospital of Dalian University, Dalian City, Liaoning Province, People’s Republic of ChinaCorrespondence: Yongqiang ...
Xie J, Wan Y, Zhang M, Jin Z, Yao Y
doaj  

Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis

Drug Design, Development and Therapy, 2022
Lina Wei,1 Xulei Gou,2 Baoning Su,3 Haiqiong Han,4 Tingting Guo,5 Liang Liu,5 Lei Wang,5 Lina Zhang,3 Weibin Chen6 1Children’s Medical Center, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, 130021, People’s ...
Wei L, Gou X, Su B, Han H, Guo T, Liu L, Wang L, Zhang L, Chen W   +8 more
doaj  

FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR

BMC Cancer, 2019
Background Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma remains unclear.
Lei Li, Shuai Zhang, Hao Li, Haiyan Chou
doaj   +1 more source

Clinical Development of FGFR3 Inhibitors for the Treatment of Urothelial Cancer

Bladder Cancer, 2019
The fibroblast growth factor receptor 3 (FGFR3) plays critical roles in driving oncogenesis of a subset of patients with urothelial carcinomas (UC). Growing evidence from preclinical studies suggests that FGFR3 inhibition can reduce proliferation and ...
Tony Ibrahim, Marco Gizzi, Ratislav Bahleda, Yohann Loriot   +3 more
doaj   +1 more source

Lumbar Disc Degeneration is Facilitated by MiR-100-Mediated FGFR3 Suppression

Cellular Physiology and Biochemistry, 2015
Background/Aims: The pathogenesis of lumbar disc degeneration (LDD) involved activation of matrix metalloproteinase 13 (MMP13) by differential expression of fibroblast growth factor receptor 1 (FGFR1) and FGFR3.
Ning Yan, Shunzhi Yu, Hailong Zhang, Tiesheng Hou   +3 more
doaj   +1 more source