Results 121 to 130 of about 681,792 (231)

Upfront Comprehensive Genomic Profiling in Advanced Biliary Tract Cancer: Real‐World Implementation and Clinical Outcomes

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Biliary Tract Cancers (BTCs) are difficult‐to‐treat malignancies with limited therapeutic options and dismal prognosis. Upfront comprehensive genomic profiling (CGP) is recommended for advanced BTC to identify actionable alterations, but its real‐world implementation remains underexplored. Methods In 2019, we implemented upfront CGP
Saskia Hussung, Mia Roth, Dilara Akhoundova, Clelia Pistoni, Judith Konrat, Franca Lisy, Tabea Ibach, Tomas Brezina, Markus Rechsteiner, Daniela Lenggenhager, Martin Zoche, Holger Moch, Achim Weber, Ralph Fritsch   +13 more
wiley   +1 more source

In situ imaging of quantum dot-AZD4547 conjugates for tracking the dynamic behavior of fibroblast growth factor receptor 3

International Journal of Nanomedicine, 2017
Gyoyeon Hwang,1,2,* Hyeonhye Kim,1,* Hojong Yoon,1 Chiman Song,1 Dong-Kwon Lim,3 Taebo Sim,1,3 Jiyeon Lee1,2 1Chemical Kinomics Research Center, Materials and Life Science Research Division, Korea Institute of Science and Technology, Seoul, 2Bio-Med ...
Hwang G, Kim H, Yoon H, Song C, Lim D, Sim T, Lee J   +6 more
doaj  

The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

Frontiers in Immunology
BackgroundTraumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic activity and release of cytokines.
Rida Rehman, Rida Rehman, Albrecht Froehlich, Florian olde Heuvel, Lobna Elsayed, Tobias Boeckers, Tobias Boeckers, Markus Huber-Lang, Cristina Morganti-Kossmann, Cristina Morganti-Kossmann, Francesco Roselli, Francesco Roselli   +11 more
doaj   +1 more source

FGFR inhibitors combined with nab-paclitaxel - A promising strategy to treat non-small cell lung cancer and overcome resistance. [PDF]

Front Oncol, 2023
Ma F, Zhu X, Niu Y, Nai A, Bashir S, Xiong Y, Dong Y, Li Y, Song J, Xu M.   +9 more
europepmc   +1 more source

Small-molecule Inhibitors of Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinases (TK).

, 2003
Fibroblast growth factor receptors (FGFR) are members of a family of polypeptides synthesized by a variety of cell types during the processes of embryonic development and in adult tissues.
MANETTI, FABRIZIO, BOTTA, MAURIZIO
core   +1 more source

Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu, Lei Wu, Kang Yang, Kang Xie, Tao Lu, Tiangxiang Huang, Dengfeng Wan, Tao Song, Longbo Zhang   +8 more
wiley   +1 more source

Liquid Biopsy: Past, Present, and Future

MedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu, Dianjie Zeng, Keran Zhao, Yuxi Wang, Huijie Hu, Fei Deng, Yinhuai Wang, Liya Sun, Liangmin Fu   +8 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

FGFR Inhibitors in Cholangiocarcinoma-A Novel Yet Primary Approach: Where Do We Stand Now and Where to Head Next in Targeting This Axis? [PDF]

Cells, 2022
Chmiel P, Gęca K, Rawicz-Pruszyński K, Polkowski WP, Skórzewska M.   +4 more
europepmc   +1 more source

FGFR Inhibitor [PDF]

, 2020
openaire   +1 more source