Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors
Molecules, 2017 Abnormality of fibroblast growth factor receptor (FGFR)-mediated signaling pathways were frequently found in various human malignancies, making FGFRs hot targets for cancer treatment. To address the consistent need for a new chemotype of FGFR inhibitors,
Yan Zhang +10 more
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Effects of FGFR Tyrosine Kinase Inhibition in OLN-93 Oligodendrocytes [PDF]
Cells, 2021 Fibroblast growth factor (FGF) signaling is involved in the pathogenesis of multiple sclerosis (MS). Data from neuropathology studies suggest that FGF signaling contributes to the failure of remyelination in MS.
Ranjithkumar Rajendran +8 more
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Pharmacological ResearchImmune checkpoint inhibitors (ICIs) are essential for urothelial carcinoma (UC) treatment. Fibroblast growth factor receptor (FGFR) alterations, as common oncogenic drivers in UC, have been reported to drive T cell depletion of UC immune microenvironment
Yuxuan Song +5 more
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Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
Molecular CancerFibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes, such as metabolism and signal transduction, but can also drive tumorigenesis.
Mei Peng, Jun Deng, Xiangping Li
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FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors. [PDF]
Biochim Biophys Acta Rev Cancer, 2021 Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been extensively investigated in solid malignancies, representing an attractive therapeutic target. In breast cancer, especially in estrogen receptor positive (ER+) subtype, FGFR signaling
Servetto A, Formisano L, Arteaga CL.
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Fibroblast Growth Factor Receptor (FGFR) Inhibitors in Urothelial Cancer [PDF]
Oncologist, 2020 Yousef Zakharia, Rohan Garje
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Recent Advances in Tumor Therapy Targeting FGFR
Zhongliu Fangzhi Yanjiu, 2022 Abnormal FGFR signaling has been found in a variety of cancers. The abnormal FGFR signaling is involved in several processes of tumorigenesis which include cell survival, proliferation, inflammation, migration, angiogenesis, epithelial-mesenchymal ...
ZHANG Jing +4 more
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Targeted Therapies in Advanced Cholangiocarcinoma: A Focus on FGFR Inhibitors. [PDF]
Medicina (Kaunas), 2021 Despite advanced diseases continuing to be associated with grim prognoses, the past decade has witnessed the advent of several novel treatment options for cholangiocarcinoma (CCA) patients.
Rizzo A.
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Supplementary Figure 3 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
, 2023 Acquisition of mutations in PI3K/TSC1 pathway at progression to FGFR inhibitors.
Rastislav Bahleda (16617234) +21 more
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Supplementary Table 2 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
, 2023 Systemic treatment received by patients prior to selective FGFR inhibitors, according to the detection of FGFR kinase domain mutations and/or PI3K/mTOR pathway alterations.
Rastislav Bahleda (16617234) +21 more
core +2 more sources