Results 201 to 210 of about 14,279 (236)
Development of Fibrates as Important Scaffolds in Medicinal Chemistry
ChemMedChem, 2019 Fibrates are a class of phenoxyisobutyric acid derivatives mainly used as anti-hyperlipidemic agents. The fibrate scaffold has undergone a variety of chemical modifications, providing a wide spectrum of biological activities.
Barbara de Filippis +2 more
exaly +2 more sources
Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis
Lancet, The, 2010 Background Several clinical trials have reported inconsistent findings for the effect of fibrates on cardiovascular risk. We undertook a systematic review and meta-analysis to investigate the effects of fibrates on major clinical outcomes.
Bruce Neal, Alan Cass, Vlado Perkovic
exaly +2 more sources
Statins, fibrates, and venous thromboembolism: a meta-analysis [PDF]
European Heart Journal, 2010 Aims The aim is to make a systematic review of the literature to assess the effect of lipid-lowering drugs on venous thromboembolism (VTE) occurrence. Methods and results MEDLINE and EMBASE databases were searched to identify studies that evaluated the
Alessandro Squizzato +2 more
exaly +2 more sources
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2005
Atherosclerosis of the large arteries is the main origin of cerebro- and cardiovascular diseases, the leading causes of mortality and morbidity in industrialized countries. The pathophysiology of coronary and cerebrovascular atherosclerosis is multifactorial and complex. Fibrates are hypolipidemic drugs that lower progression of atherosclerotic lesions
R, Robillard +4 more
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Atherosclerosis of the large arteries is the main origin of cerebro- and cardiovascular diseases, the leading causes of mortality and morbidity in industrialized countries. The pathophysiology of coronary and cerebrovascular atherosclerosis is multifactorial and complex. Fibrates are hypolipidemic drugs that lower progression of atherosclerotic lesions
R, Robillard +4 more
openaire +2 more sources
Israel Journal of Mathematics, 2003
Preservation of homotopical structures by localization functors is a classical question in homotopy theory. In this paper the authors obtain necessary and sufficient conditions for a fibration sequence to be preserved by a nullification functor. Also, nullification functors \(L=P_W\) are characterized among localization functors \(L_f\) defined by ...
Berrick, A.J., Dror Farjoun, E.
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Preservation of homotopical structures by localization functors is a classical question in homotopy theory. In this paper the authors obtain necessary and sufficient conditions for a fibration sequence to be preserved by a nullification functor. Also, nullification functors \(L=P_W\) are characterized among localization functors \(L_f\) defined by ...
Berrick, A.J., Dror Farjoun, E.
openaire +1 more source
Approximating Approximate Fibrations by Fibrations
Canadian Journal of Mathematics, 1977A map p: E → B between metric spaces has the approximate homotopy lifting property with respect to the space X if given a cover Ū of B and maps g: X → E and H: X × [0, 1] → B such that H(x, 0) = pg(x) for all x ϵ X, then there exists a map G: X × [0, 1] → E such that G(x, 0) = g(x) and pGt and Ht are Ū-close for all x ϵ X and t ϵ [0, 1]; i.e. given (x,
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Proceedings of the National Academy of Sciences, India Section A: Physical Sciences, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ege, Ozgur, Karaca, Ismet
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zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ege, Ozgur, Karaca, Ismet
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Canadian Mathematical Bulletin, 1967
If one considers the theories of Hurewicz, - Serre - or other fibrations in the categories of topological or pointed topological spaces, one can see that many of the fundamental theorems can be formulated and proven in the general case of categories for which certain functors and natural transformations are given.
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If one considers the theories of Hurewicz, - Serre - or other fibrations in the categories of topological or pointed topological spaces, one can see that many of the fundamental theorems can be formulated and proven in the general case of categories for which certain functors and natural transformations are given.
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Cardiology in Review, 2008
Fibrates are a class of lipid-lowering medication primarily used as second-line agents behind statins. Acting via the peroxisome proliferators-activated receptor-alpha, their main lipoprotein effects are to lower serum triglyceride levels and to raise high-density lipoprotein-cholesterol, with modest effects on low-density lipoprotein-cholesterol ...
Joshua, Remick +5 more
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Fibrates are a class of lipid-lowering medication primarily used as second-line agents behind statins. Acting via the peroxisome proliferators-activated receptor-alpha, their main lipoprotein effects are to lower serum triglyceride levels and to raise high-density lipoprotein-cholesterol, with modest effects on low-density lipoprotein-cholesterol ...
Joshua, Remick +5 more
openaire +2 more sources
Nihon rinsho. Japanese journal of clinical medicine, 2014
Although fibrates was a medicine with a long history, at the clinical spot, the profitability had not permeated as compared with statin. However, many-sided effects, such as a fall of a cardiovascular event and control of arteriosclerosis prevention and a diabetic microangiopathy, were reported as a result of the large-scale clinical test in recent ...
Fumihiko, Hara, Junichi, Yamazaki
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Although fibrates was a medicine with a long history, at the clinical spot, the profitability had not permeated as compared with statin. However, many-sided effects, such as a fall of a cardiovascular event and control of arteriosclerosis prevention and a diabetic microangiopathy, were reported as a result of the large-scale clinical test in recent ...
Fumihiko, Hara, Junichi, Yamazaki
openaire +1 more source