Results 71 to 80 of about 340,737 (387)

Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model

JOR Spine, 2023
Background Intervertebral disc (IVD) disorders (e.g., herniation) directly contribute to back pain, which is a leading cause of global disability. Next‐generation treatments for IVD herniation need advanced preclinical testing to evaluate their ability ...
Christopher J. Panebianco, Caroline Constant, Andrea J. Vernengo, Dirk Nehrbass, Dominic Gehweiler, Tyler J. DiStefano, Jesse Martin, David J. Alpert, Saad B. Chaudhary, Andrew C. Hecht, Alan C. Seifert, Steven B. Nicoll, Sibylle Grad, Stephan Zeiter, James C. Iatridis   +14 more
doaj   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions [PDF]

, 2015
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone.
A Andreoli, AA Pahlevan, AC Chany, Alexander Stainer, AM Healy, B Isermann, B Roche, Belinda S. Hall, BS Hall, C Bozzo, C Simpson, CA Moxon, Charles T. Esmon, CJ d'Adhemar, CT Esmon, CT Esmon, CT Esmon, D Mehta, D Schutte, D Yeboah-Manu, DH Connor, DJ Stearns-Kurosawa, DS Walsh, E Coutanceau, E Coutanceau, E Torrado, E Zavattaro, F Song, FS Sarfo, FS Sarfo, G Archipoff, G Kunz, Gerd Pluschke, HC Huang, Hua-Lin Wu, I Maruyama, J Ahnstrom, JJ Peterson, JM Kanga, Josefin Ahnström, Joy Ogbechi, K Fukudome, Katherine Bodman-Smith, KM George, KM George, KY Hui, L Guenin-Mace, LO Mosnier, M Chu, Marcel A. Behr, Marie-Thérèse Ruf, Moritz Vogel, MT Ruf, MT Ruf, MT Ruf, MT Ruf, MT Silva, MW Boehme, PJ Converse, PP Nawroth, Rachel E. Simmonds, RE Simmonds, RE Simmonds, RO Phillips, RW Merritt, S Adusumilli, S Navarro, S Vaiyapuri, S Vaiyapuri, TJ Raife, TL Cheng, TL Le, VW van Hinsbergh, WA Nienhuis, X Ye, YY Hsu   +75 more
core   +5 more sources

Integrating platelet and coagulation activation in fibrin clot formation

Research and Practice in Thrombosis and Haemostasis, 2018
Platelets interact with the coagulation system in a multitude of ways, not only during the phases of thrombus formation, but also in specific areas within a formed thrombus.
F. Swieringa, H. Spronk, J. Heemskerk, P. V. D. van der Meijden   +3 more
semanticscholar   +1 more source

Enhanced Thrombotic Responses Are Associated With Striatin Deficiency and Aldosterone

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background In addition to its role on blood pressure, aldosterone (ALDO) also affects the hemostatic system leading to increased experimental thrombosis. Striatin is an intermediate in the rapid, nongenomic actions of ALDO. Striatin heterozygote knockout
Anna Gromotowicz‐Poplawska, Robert Flaumenhaft, Shadi K. Gholami, Glenn Merrill‐Skoloff, Ewa Chabielska, Gordon H. Williams, Jose R. Romero   +6 more
doaj   +1 more source

A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

Advanced Functional Materials, EarlyView.
A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo, Chiara Arrigoni, Tobias Faehling, Antonietta Verrillo, Viviana Secci, Thomas G. P. Grünewald, Giuseppe Talò, Alexandra Kummer, Jorge Gonzalez, Vincenzo De Rosa, Christian Candrian, Andrea Barbero, Florencia Cidre‐Aranaz, Matteo Moretti   +13 more
wiley   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

The Applicability of Current Turbidimetric Approaches for Analyzing Fibrin Fibers and Other Filamentous Networks

Biomolecules, 2022
Turbidimetry is an experimental technique often used to study the structure of filamentous networks. To extract structural properties such as filament diameter from turbidimetric data, simplifications to light scattering theory must be employed.
Heather A. Belcher, Karen Litwa, Martin Guthold, Nathan E. Hudson   +3 more
doaj   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Guidelines on fibrinogen assays [PDF]

, 2003
No abstract ...
Becker, Blanco, Blomback, Cambas, Chantarangkul, Chantarangkul, Chitolie, Chitolie, Clauss, Cremer, Cushman, De Cristofaro, De Maat, De Metz, Eliasson, Gaffney, Gordon D. O. Lowe, Hantgan, Haverkate, Hoffmann, Humphries, Ian J. Mackie, Jacobsson, Kitchen, Kluft, Lawrie, Lowe, Lowe, Ludlam, Machin, Mackie, Marder, MDA, MDA, Natelson, NCCLS, Nieuwenhuizen, Oosting, Palareti, Rampling, Ratnoff, Rosenson, Rossi, Samuel J. Machin, Steven Kitchen, Swain, Sweetnam, Sweetnam, Thompson, Van Der Bom, Vermylen, Whicher, World Health Organisation Report   +52 more
core   +1 more source