Journal of Cardiothoracic Surgery, 2023 Objective This study aims to examine the impact of preoperative fibrinogen concentration on the short-term outcomes and hospital length of stay (LOS) of patients undergoing Coronary Artery Bypass Grafting (CABG).
Chunsheng Huang +5 more
doaj +1 more source
Cells, 2020 Immune complexes containing citrullinated fibrinogen are present in the sera and synovium of rheumatoid arthritis patients and potentially contribute to synovitis. However, fibrinogen can inhibit the osteoclastogenesis of precursor cells. We investigated
Ji Soo Kim +7 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric ...
Elise J. Huisman +3 more
doaj +1 more source
Erythrocyte sedimentation: Effect of aggregation energy on gel structure during collapse [PDF]
Phys. Rev. E 105, 024610 (2022), 2021 The erythrocyte (or red blood cell) sedimentation rate (ESR) is commonly interpreted as a measure of cell aggregation and as a biomarker of inflammation. It is well known that an increase of fibrinogen concentration, an aggregation-inducing protein for erythrocytes, leads to an increase of the sedimentation rate of erythrocytes, which is generally ...
arxiv +1 more source
Interaction of fibrinogen-magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes [PDF]
Nanoscale, 2020, 12, 19918, 2020 Magnetic nanoparticles have a broad spectrum of biomedical applications including cell separation, diagnostics and therapy. One key issue is little explored: how do the engineered nanoparticles interact with blood components after injection? The formation of bioconjugates in the bloodstream and subsequent reactions are potentially toxic due to the ...
arxiv +1 more source
Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk
Haematologica, 2020 Complement C3 binds fibrinogen and compromises fibrin clot lysis thereby enhancing thrombosis risk. We investigated the role of fibrinogen-C3 interaction as a novel therapeutic target to reduce thrombosis risk by analysing: i) consistency in the ...
Rhodri J. King +12 more
doaj +1 more source
Prognostic Impact of Pretreatment Plasma Fibrinogen in Patients with Locally Advanced Oral and Oropharyngeal Cancer. [PDF]
PLoS ONE, 2016 We aimed to determine the prognostic significance of pretreatment plasma fibrinigen in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC).A cohort of 183 patients with locally advanced OOSCC receiving preoperative chemoradiotherapy was ...
Daniel Holzinger +10 more
doaj +1 more source
Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury. [PDF]
, 2017 Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding.
Applegate, Richard +12 more
core +1 more source
The use of fibrinogen concentrate for the management of trauma-related bleeding. A systematic review and meta-analysis [PDF]
, 2017 Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in ...
Franchini, Massimo +6 more
core +1 more source
DNA methylation profiling of the fibrinogen gene landscape in human cells and during mouse and zebrafish development. [PDF]
PLoS ONE, 2013 The fibrinogen genes FGA, FGB and FGG show coordinated expression in hepatocytes. Understanding the underlying transcriptional regulation may elucidate how their tissue-specific expression is maintained and explain the high variability in fibrinogen ...
Silja Vorjohann +6 more
doaj +1 more source