Results 11 to 20 of about 329,091 (399)

Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial

Critical Care, 2018
Background There is increasing interest in the timely administration of concentrated sources of fibrinogen to patients with major traumatic bleeding. Following evaluation of early cryoprecipitate in the CRYOSTAT 1 trial, we explored the use of fibrinogen
Nicola Curry, Claire Foley, Henna Wong, Ana Mora, Elinor Curnow, Agne Zarankaite, Renate Hodge, Valerie Hopkins, Alison Deary, James Ray, Phil Moss, Matthew J. Reed, Suzanne Kellett, Ross Davenport, Simon Stanworth   +14 more
doaj   +2 more sources

A Novel Inflammation-Based Prognostic Score: The Fibrinogen/Albumin Ratio Predicts Prognoses of Patients after Curative Resection for Hepatocellular Carcinoma

Journal of Immunology Research, 2018
Background. Inflammation is an important hallmark of cancer. Fibrinogen and albumin are both vital factors in systemic inflammation. This study investigated the prognostic value of the fibrinogen/albumin ratio in HCC patients who underwent curative ...
Qiaodong Xu, Yongcong Yan, Songgang Gu, Kai Mao, Jianlong Zhang, Pinbo Huang, Zhenyu Zhou, Zheng Chen, Shaodong Zheng, Jiahong Liang, Zhihua Lin, Jie Wang, Jiang Yan, Zhiyu Xiao   +13 more
doaj   +2 more sources

Fibrinogen and Atherosclerotic Cardiovascular Diseases—Review of the Literature and Clinical Studies

International Journal of Molecular Sciences, 2021
Atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease, cerebrovascular disease, and peripheral arterial disease, represent a significant cause of premature death worldwide.
S. Surma, M. Banach
semanticscholar   +1 more source

Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients

Frontiers in Cellular and Infection Microbiology, 2021
Background The coronavirus disease-19 (COVID-19) is characterized with intense inflammatory response, cardiac involvement, and coagulopathy. Fibrinogen, as a biomarker for inflammation, cardiovascular disease, and coagulation, has not been fully ...
Jingrui Sui, D. Noubouossie, S. Gandotra, Liyun Cao   +3 more
semanticscholar   +1 more source

The Conversion of Fibrinogen to Fibrin: Recombinant Fibrinogen Typifies Plasma Fibrinogen [PDF]

Blood, 1997
AbstractPlasma fibrinogen is a mixture of multiple molecular forms arising mainly through alternative mRNA processing and subsequent posttranslational modification. Recombinant fibrinogen is synthesized without alternative mRNA processing in a cultured cell system that may generate novel posttranslational modifications.
Yuri Veklich, John W. Weisel, Oleg V. Gorkun, Susan T. Lord   +3 more
openaire   +3 more sources

Fibrinogen is an independent preoperative predictor of hospital length of stay among patients undergoing coronary artery bypass grafting

Journal of Cardiothoracic Surgery, 2023
Objective This study aims to examine the impact of preoperative fibrinogen concentration on the short-term outcomes and hospital length of stay (LOS) of patients undergoing Coronary Artery Bypass Grafting (CABG).
Chunsheng Huang, Wenyuan Zhang, Xiaofei Chen, Xia Xu, Jun Qiu, Zhihao Pan   +5 more
doaj   +1 more source

Implication of the Association of Fibrinogen Citrullination and Osteoclastogenesis in Bone Destruction in Rheumatoid Arthritis

Cells, 2020
Immune complexes containing citrullinated fibrinogen are present in the sera and synovium of rheumatoid arthritis patients and potentially contribute to synovitis. However, fibrinogen can inhibit the osteoclastogenesis of precursor cells. We investigated
Ji Soo Kim, Mikyung Choi, Ji Yong Choi, Joo Yeon Kim, Jeong Yeon Kim, Jin-Su Song, Lionel B. Ivashkiv, Eun Young Lee   +7 more
doaj   +1 more source

Pediatric Fibrinogen PART I—Pitfalls in Fibrinogen Evaluation and Use of Fibrinogen Replacement Products in Children

Frontiers in Pediatrics, 2021
Fibrinogen is a key coagulation protein, playing a critical role in hemostasis. It is the first factor to decrease to critical levels during bleeding. Hypofibrinogenemia is an important risk factor for bleeding in clinical settings, including pediatric ...
Elise J. Huisman, Elise J. Huisman, Elise J. Huisman, Gemma Louise Crighton   +3 more
doaj   +1 more source

Erythrocyte sedimentation: Effect of aggregation energy on gel structure during collapse [PDF]

Phys. Rev. E 105, 024610 (2022), 2021
The erythrocyte (or red blood cell) sedimentation rate (ESR) is commonly interpreted as a measure of cell aggregation and as a biomarker of inflammation. It is well known that an increase of fibrinogen concentration, an aggregation-inducing protein for erythrocytes, leads to an increase of the sedimentation rate of erythrocytes, which is generally ...
arxiv   +1 more source

Interaction of fibrinogen-magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes [PDF]

Nanoscale, 2020, 12, 19918, 2020
Magnetic nanoparticles have a broad spectrum of biomedical applications including cell separation, diagnostics and therapy. One key issue is little explored: how do the engineered nanoparticles interact with blood components after injection? The formation of bioconjugates in the bloodstream and subsequent reactions are potentially toxic due to the ...
arxiv   +1 more source