The Conversion of Fibrinogen to Fibrin: Recombinant Fibrinogen Typifies Plasma Fibrinogen [PDF]
Blood, 1997 AbstractPlasma fibrinogen is a mixture of multiple molecular forms arising mainly through alternative mRNA processing and subsequent posttranslational modification. Recombinant fibrinogen is synthesized without alternative mRNA processing in a cultured cell system that may generate novel posttranslational modifications.
Yuri Veklich +3 more
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Journal of Clinical Pathology, 1965 Platelet fibrinogen has been studied in normal, thrombasthenic, and hypofibrinogenaemic subjects. It has been differentiated into adsorbed (plasma) and extractable (intraplatelet) fractions. Isotopic studies suggest that exchange does not occur between intraplatelet and plasma fibrinogen and it appears possible that the intra-platelet fraction may be ...
P.A. Castaldi, J Caen
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Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury. [PDF]
, 2017 Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding.
Applegate, Richard +12 more
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The use of fibrinogen concentrate for the management of trauma-related bleeding. A systematic review and meta-analysis [PDF]
, 2017 Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in ...
Franchini, Massimo +6 more
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Canine reference intervals for coagulation markers using the STA Satellite and the STA-R Evolution analyzers [PDF]
, 2010 The aim of the current study was to determine canine reference intervals for prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, and antithrombin (AT) according to international recommendations. The STA Satellite coefficients
Braun, Jean-Pierre +5 more
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DNA methylation profiling of the fibrinogen gene landscape in human cells and during mouse and zebrafish development. [PDF]
PLoS ONE, 2013 The fibrinogen genes FGA, FGB and FGG show coordinated expression in hepatocytes. Understanding the underlying transcriptional regulation may elucidate how their tissue-specific expression is maintained and explain the high variability in fibrinogen ...
Silja Vorjohann +6 more
doaj +1 more source
Fibrinogen metabolic responses to trauma
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2009 Coagulation complications are significant contributors to morbidity and mortality in trauma patients. Although the lethal triad of hypothermia, acidosis and coagulopathy has been recognized for over a decade, the underlying mechanisms related to the ...
Martini Wenjun
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Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland [PDF]
, 2003 There is increasing evidence that blood viscosity and its major determinants (haematocrit, plasma viscosity and fibrinogen) are associated with an increased risk of incident cardiovascular events; however, their associations with mortality are not ...
Ann Rumley +29 more
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The Saudi Journal of Gastroenterology, 2014 The mutation γ375Arg → Trp (fibrinogen Aguadilla) is one of four mutations (Brescia, Aguadilla, Angers, and AI duPont) capable of causing hepatic storage of fibrinogen.
Abdulrahman Al-Hussaini +6 more
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