Results 31 to 40 of about 4,278 (228)
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, EarlyView.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
Dose de-escalation of intrapleural tissue plasminogen activator therapy for pleural infection. The alteplase dose assessment for Pleural infection Therapy project [PDF]
, 2017 Rationale: Intrapleural therapy with a combination of tissue plasminogen activator (tPA) 10 mg and DNase 5 mg administered twice daily has been shown in randomized and open-label studies to successfully manage over 90% of patients with pleural infection ...
Bintcliffe, Oliver +10 more
core +1 more source
Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities
Arthritis &Rheumatology, EarlyView.Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. While oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear.
Matteo Becatti +13 more
wiley +1 more source
Veterinary Staphylo-Fibrinolysin.
Experimental Biology and Medicine, 1936 In an examination of 132 local strains of staphylococci† it was found that 80% of all strains originally isolated from internal human lesions are capable of liquefying human fibrin.1 Approximately 90% of all strains isolated from superficial human infections, however, and all strains isolated from veterinary lesions are non-lytic by the same in vitro ...
Edward E. Dart, R. R. Madison
openaire +2 more sources
Clinical Advances in Periodontics, EarlyView.Abstract Background In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable ...
Behzad Houshmand +7 more
wiley +1 more source
Stability of Thrombin in the Presence of Fibrinolysin.
Experimental Biology and Medicine, 1947 SummaryIt has been shown that fibrinolysin does not affect the clotting activity of thrombin, and that the thrombin preparation increased the stability of fibrinolysin under the conditions of these experiments.
openaire +4 more sources
Antifibrinolytic Activity of Derivatives of Fibrinolysin.
Experimental Biology and Medicine, 1956 SummaryDerivatives of bovine fibrinolysin have been prepared which inhibited the enzyme from which they are derived, but did not inhibit human fibrinolytic activity.
Edmund Klein, Isaac Djerassi
openaire +3 more sources
Clinical evaluation of Eustachian tube transience and function in patients with different types of increased nasal resistance [PDF]
, 2009 Background/Aim. Eustachian tube is a connection between throat and the middle ear. Inflammatory processes and malformations of nasal cavity could lead to dysfunction of the whole upper respiratory tract, this emphasizing the evaluation of the Eustachian ...
Andrić Vukašin +3 more
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu +9 more
wiley +1 more source