Results 51 to 60 of about 4,278 (207)
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, Volume 16, Issue 2, Page 314-330, February 2026.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins [PDF]
, 1998 Nobuaki Hiraoka +4 more
openalex +1 more source
Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer +4 more
wiley +1 more source
Biomedical Chromatography, Volume 40, Issue 2, February 2026.ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar +4 more
wiley +1 more source
Enzyme Production and Inhibitory Potential of <i>Pseudomonas aeruginosa</i>: Contrasting Clinical and Environmental Isolates. [PDF]
Antibiotics (Basel), 2023 Aqel H +3 more
europepmc +1 more source
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Central nervous system (CNS) hemorrhage is a serious complication of intravenous thrombolysis. Tenecteplase, a fibrin‐specific thrombolytic agent, has a lower risk of hemorrhage than other agents. We report the first documented case of simultaneous intracranial and spinal hemorrhage following intravenous administration of tenecteplase.
Thamalee Palliyaguru +4 more
wiley +1 more source
Effects of Intravenous Administration of Fibrinolysin (Plasmin) in Man [PDF]
, 1959 Kenneth Μ. Moser
openalex +1 more source
Clinical Case Reports, Volume 14, Issue 2, February 2026.ABSTRACT Immunoglobulin replacement therapy (IRT) for primary immunodeficiency reduces infection risk and subsequent complications and can be lifesaving. However, IRT can cause severe systemic adverse events (AEs) that may limit adequate dosing. These AEs may be caused, in part, by activation and/or consumption of complement proteins, thereby lowering ...
Douglas H. Jones, Heidi Memmott
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao +8 more
wiley +1 more source
Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Quantitative systems pharmacology (QSP) models offer a useful platform to integrate drug pharmacology with knowledge about biological mechanisms across multiple scales and data sources into a unified quantitative framework. This makes them invaluable to address many relevant questions in drug research and development.
Johannes Tillil +2 more
wiley +1 more source