Results 1 to 10 of about 80,628 (257)

Extent of peritoneal metastases from colorectal cancer is not associated with changes in thrombin generation or fibrinolysis [PDF]

Pleura and Peritoneum
Cancer cells can activate coagulation and inhibit fibrinolysis. The aim was to investigate the association between the burden of peritoneal metastases from colorectal cancer (PM-CRC) and biomarkers reflecting thrombin generation and fibrinolysis.
Lundbech Mikkel, Krag Andreas Engel, Iversen Lene Hjerrild, Brandsborg Birgitte, Hvas Anne-Mette   +4 more
doaj   +2 more sources

Abnormal plasma clot formation and fibrinolysis reveal bleeding tendency in patients with partial factor XI deficiency

Blood Advances, 2018
: Individuals with factor XI (FXI) deficiency have a variable bleeding risk that cannot be predicted from plasma FXI antigen or activity. This limitation can result in under- or overtreatment of patients and risk of bleeding or thrombosis.
Gillian N. Gidley, Lori A. Holle, John Burthem, Paula H.B. Bolton-Maggs, Feng-Chang Lin, Alisa S. Wolberg   +5 more
doaj   +2 more sources

Use of Affimer technology for inhibition of α2-antiplasmin and enhancement of fibrinolysis [PDF]

Blood Advances
:: Hypofibrinolysis is a documented abnormality in conditions with high risk of vascular occlusion. A key inhibitor of fibrinolysis is α2-antiplasmin (α2AP), and we hypothesize that the Affimer technology, comprising small conformational proteins with 2 ...
Nikoletta Pechlivani, Basmah Alsayejh, Mansour Almutairi, Katie Simmons, Thembaninkosi Gaule, Fladia Phoenix, Noppadol Kietsiriroje, Sreenivasan Ponnambalam, Cédric Duval, Robert A.S. Ariëns, Christian Tiede, Darren C. Tomlinson, Ramzi A. Ajjan   +12 more
doaj   +2 more sources

Hyperfibrinolysis: a crucial phenotypic abnormality of posttraumatic fibrinolytic dysfunction [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Traumatic fibrinolytic dysfunction is often categorized into 3 phenotypes based on the result of thromboelastography (TEG) lysis at 30 minutes (LY30): fibrinolysis shutdown, physiologic fibrinolysis, and hyperfibrinolysis.
Kyosuke Takahashi, Kazuma Yamakawa, Anaar E. Siletz, Morihiro Katsura, John B. Holcomb, Charles E. Wade, Jessica C. Cardenas, Erin E. Fox, Morgan Schellenberg, Matthew Martin, Kenji Inaba, Kazuhide Matsushima   +11 more
doaj   +2 more sources

Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review

International Journal of Molecular Sciences, 2021
Thrombin activatable fibrinolysis inhibitor (TAFI), a proenzyme, is converted to a potent attenuator of the fibrinolytic system upon activation by thrombin, plasmin, or the thrombin/thrombomodulin complex.
M. Sillen, P. Declerck
semanticscholar   +1 more source

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

Blood Advances, 2021
The high incidence of thrombotic events suggests a possible role of the contact system pathway in COVID-19 pathology. Here, we demonstrate altered levels of factor XII (FXII) and its activation products in critically ill COVID-19 patients in comparison
M. Wygrecka, A. Birnhuber, B. Seeliger, Laura Michalick, O. Pak, Astrid-Solveig Schultz, Fabian Schramm, M. Zacharias, G. Gorkiewicz, S. David, T. Welte, Julius J Schmidt, N. Weissmann, R. Schermuly, G. Barreto, L. Schaefer, P. Markart, M. Brack, S. Hippenstiel, F. Kurth, L. Sander, M. Witzenrath, W. Kuebler, G. Kwapiszewska, K. Preissner   +24 more
semanticscholar   +1 more source

Fibrinolysis vs. primary percutaneous coronary intervention for ST‐segment elevation myocardial infarction cardiogenic shock

ESC Heart Failure, 2021
Aims There are limited contemporary data on the use of initial fibrinolysis in ST‐segment elevation myocardial infarction cardiogenic shock (STEMI‐CS). This study sought to compare the outcomes of STEMI‐CS receiving initial fibrinolysis vs.
Saraschandra Vallabhajosyula, Dhiran Verghese, Malcolm R. Bell, Dennis H. Murphree, Wisit Cheungpasitporn, P. Elliott Miller, Shannon M. Dunlay, Abhiram Prasad, Gurpreet S. Sandhu, Rajiv Gulati, Mandeep Singh, Amir Lerman, Bernard J. Gersh, David R. Holmes Jr, Gregory W. Barsness   +14 more
doaj   +1 more source

Fibrinolytic therapy use for ST-segment elevation myocardial infarction and long-term outcomes in China: 2-year results from the China Acute Myocardial Infarction Registry

BMC Cardiovascular Disorders, 2023
Background Data on fibrinolytic therapy use for ST-segment elevation myocardial infarction (STEMI) and long-term clinical outcomes in developing countries are limited.
Chao Wu, Ling Li, Shuqing Wang, Jianping Zeng, Jingang Yang, Haiyan Xu, Yanyan Zhao, Yang Wang, Wei Li, Chen Jin, Xiaojin Gao, Yuejin Yang, Shubin Qiao   +12 more
doaj   +1 more source

Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients.

PLoS ONE, 2021
BackgroundThe effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients ...
Il-Jae Wang, Byung-Kwan Bae, Young Mo Cho, Suck Ju Cho, Seok-Ran Yeom, Sang-Bong Lee, Mose Chun, Hyerim Kim, Hyung-Hoi Kim, Sun Min Lee, Up Huh, Soo Young Moon   +11 more
doaj   +1 more source

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

Critical Care, 2023
Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g.
Lucy A. Coupland, David J. Rabbolini, Jonathan G. Schoenecker, Philip J. Crispin, Jennene J. Miller, Tony Ghent, Robert L. Medcalf, Anders E. Aneman   +7 more
doaj   +1 more source