Results 91 to 100 of about 80,628 (257)

Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis

Small Structures, EarlyView.
Based on individualized design for critical bone defect, biological bone is cut by subtractive manufacturing, sintered into biological hydroxyapatite (BHA) scaffolds, and masked with extracellular matrix‐gelatin hydrogel (ECM‐gel) to prepare gelatin hydrogel‐masked BHA (G‐BHA) scaffolds.
Jieyun Xu, Xiaoran Yu, Hongcheng Chen, Junlong Xue, Zhuohong Gong, Zhengjie Shan, Shijie Chen, Yuanlong Guo, Xiaomeng Gao, Linjun Zhang, Yin Xiao, Feilong Deng, Zetao Chen   +12 more
wiley   +1 more source

Internal fibrinolysis of fibrin clots is driven by pore expansion

Scientific Reports
Blood clots, which are composed of blood cells and a stabilizing mesh of fibrin fibers, are critical in cessation of bleeding following injury. However, their action is transient and after performing their physiological function they must be resolved ...
Rebecca A. Risman, Bradley Paynter, Victoria Percoco, Mitali Shroff, Brittany E. Bannish, Valerie Tutwiler   +5 more
doaj   +1 more source

Comparison of intrapleural use of urokinase and tissue plasminogen activator/DNAse in pleural infection

ERJ Open Research, 2019
Fibrinolysis can be used to improve fluid drainage in pleural infection. Treatment with either urokinase or tissue plasminogen activator (t-PA) in association with DNAse via a chest tube has been effective at reducing the need for surgery.
Benoît Bédat, Jérôme Plojoux, Jade Noel, Anna Morel, Jonathan Worley, Frédéric Triponez, Wolfram Karenovics   +6 more
doaj   +1 more source

Enhanced Fibrinolysis with Magnetically Powered Colloidal Microwheels.

Small, 2017
Thrombi that occlude blood vessels can be resolved with fibrinolytic agents that degrade fibrin, the polymer that forms between and around platelets to provide mechanical stability.
T. Tasci, D. Disharoon, Rogier M. Schoeman, K. Rana, P. Herson, D. Marr, K. Neeves   +6 more
semanticscholar   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, EarlyView.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source

Comparison of results obtained using clot-fibrinolysis waveform analysis and global fibrinolysis capacity assay with rotational thromboelastography

Scientific Reports
Global fibrinolysis assays detect the fibrinolysis time of clot dissolution using tissue-type plasminogen activator (tPA). Two such assays, clot-fibrinolysis waveform analysis (CFWA) and global fibrinolysis capacity (GFC) assay, were recently developed ...
Takumi Tsuchida, Mineji Hayakawa, Osamu Kumano   +2 more
doaj   +1 more source

Intrathecal Fibrinolysis for Aneurysmal Subarachnoid Hemorrhage: Evidence From Randomized Controlled Trials and Cohort Studies

Frontiers in Neurology, 2019
Background: The role of intrathecal fibrinolysis for the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH) has been widely investigated; however, the results have been contradictory.
Xiaocheng Lu, Chengyuan Ji, Jiang Wu, Wanchun You, Wei Wang, Zhong Wang, Gang Chen   +6 more
doaj   +1 more source

Molecular and Physical Mechanisms of Fibrinolysis and Thrombolysis from Mathematical Modeling and Experiments

Scientific Reports, 2017
Despite the common use of thrombolytic drugs, especially in stroke treatment, there are many conflicting studies on factors affecting fibrinolysis. Because of the complexity of the fibrinolytic system, mathematical models closely tied with experiments ...
Brittany E. Bannish, I. Chernysh, J. Keener, A. Fogelson, J. Weisel   +4 more
semanticscholar   +1 more source

Massive Bleeding as the First Clinical Manifestation of Metastatic Prostate Cancer due to Disseminated Intravascular Coagulation with Enhanced Fibrinolysis

Case Reports in Hematology, 2016
Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder associated with metastatic prostate adenocarcinoma. However, DIC with enhanced fibrinolysis as an initial presentation of prostate cancer is extremely rare.
Mónica Palma Anselmo, Gustavo Nobre de Jesus, João Madeira Lopes, Rui M. M. Victorino, João Meneses Santos   +4 more
doaj   +1 more source

Warfarin and fibrinolysis - a challenging combination: an observational cohort study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2011
Background Patients presenting with ST-segment elevation myocardial infarction (STEMI) frequently use warfarin. Fibrinolytic agents and warfarin both increase bleeding risk, but only a few studies have been published concerning the bleeding risk of ...
Luurila Harri, Väyrynen Taneli, Boyd James, Puolakka Jyrki, Saarinen Sini, Kuisma Markku   +5 more
doaj   +1 more source