Results 21 to 30 of about 99,108 (283)

uPA-mediated plasminogen activation is enhanced by polyphosphate

open access: yesHaematologica, 2020
Tissue plasminogen activator (tPA) and urokinase (uPA) differ in their modes of action. Efficient tPA-mediated plasminogen activation requires binding to fibrin.
Claire S. Whyte, Nicola J. Mutch
doaj   +1 more source

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study

open access: yesCritical Care, 2023
Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical conditions, e.g.
Lucy A. Coupland   +7 more
doaj   +1 more source

Assessment of Fibrinolysis in Sepsis Patients with Urokinase Modified Thromboelastography. [PDF]

open access: yesPLoS ONE, 2015
Impairment of fibrinolysis during sepsis is associated with worse outcome. Early identification of this condition could be of interest. The aim of this study was to evaluate whether a modified point-of-care viscoelastic hemostatic assay can detect sepsis-
Mauro Panigada   +9 more
doaj   +1 more source

The state of the fibrinolytic system in HIV-infected pregnant women and parturient women with thrombohemorrhagic risk factors

open access: yesРепродуктивная эндокринология, 2020
Purpose of the study: to explore the status of the fibrinolytic system in HIV-infected pregnant women and parturient women. Materials and methods. 120 HIV-positive pregnant women with risk factors of thrombohemorrhagic complications were examined.
С. Є. Савченко   +4 more
doaj   +1 more source

Endogenous fibrinolysis inhibitors in acute coronary syndrome

open access: yesAmerican Heart Journal Plus, 2021
Patients with acute coronary syndrome have a high residual risk of ischemic events despite current treatment methods, both invasive and antithrombotic strategies. The strategy of very early revascularization although has been suggested to improve patient
Baskaran Chandrasekar
doaj   +1 more source

Increased thrombin activatable fibrinolysis inhibitor activity is associated with hypofibrinolysis in dogs with sepsis

open access: yesFrontiers in Veterinary Science, 2023
IntroductionDisorders of coagulation are well-recognized in dogs with sepsis, but data regarding fibrinolysis disorders are limited. We aimed to characterize fibrinolysis in dogs with sepsis compared to healthy controls.
Katherine E. Sotos   +3 more
doaj   +1 more source

Apixaban Enhances Endogenous Fibrinolysis in Patients with Atrial Fibrillation [PDF]

open access: yes, 2019
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.AIMS: Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which ...
Arachchillage, Deepa RJ   +7 more
core   +3 more sources

Measuring Fibrinolysis [PDF]

open access: yesHämostaseologie, 2021
AbstractPhysiological fibrinolysis under normal conditions progresses slowly, in contrast to coagulation which is triggered rapidly to stop bleeding and defend against microbial invasion. Methods to detect fibrinolysis abnormalities are less simple and poorly standardized compared with common coagulation tests.
openaire   +2 more sources

Rationale and design of "Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)" study : A randomised trial modulating endogenous fibrinolysis in patients with acute coronary syndrome [PDF]

open access: yes, 2019
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ...
Gorog, Diana A   +5 more
core   +2 more sources

Plasma Concentrations of Tranexamic Acid in Postpartum Women After Oral Administration. [PDF]

open access: yes, 2020
OBJECTIVE: To evaluate the pharmacokinetics of tranexamic acid after oral administration to postpartum women. METHODS: We conducted a single-center pharmacokinetic study at Teaching Hospital-Jaffna, Sri Lanka, on 12 healthy postpartum women who delivered
Arulkumaran, S   +4 more
core   +1 more source

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