Results 191 to 200 of about 60,436 (245)
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Fibrinolytic System in Atherosclerosis
Seminars in Thrombosis and Hemostasis, 1986In this short review I have tried to report the literature findings and describe some of our observations on fibrinolysis and atherosclerosis. Although at this time it is difficult to state that diminished FA plays a pathogenic role in atherosclerosis, it certainly seems to represent a risk factor.
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The Plasminogen (Fibrinolytic) System
Thrombosis and Haemostasis, 1999Introduction The plasminogen (fibrinolytic) system (Fig. 1) comprises an inactive proenzyme, plasminogen, that can be converted to the active enzyme, plasmin. Plasmin degrades fibrin and activates matrix metalloproteinases (MMPs) that, in turn, degrade the extracellular matrix (ECM).1-3 Two physiological plasminogen activators (PAs ...
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Fibrinokinase and Fibrinolytic Enzymes
Nature, 1948CONFUSION has arisen concerning the terminology of the fibrinolytic enzymes and pro-enzymes contained in blood plasma. In our papers on the fibrinolytic activator contained in tissue cells1,2, we adhered to the nomenclature used by Loomis, George and Ryder3, which is adequate from a biochemical point of view, and which has also been used recently by ...
T, ASTRUP, P M, PERMIN
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Fibrinolytic system in preeclampsia
Clinica Chimica Acta, 2013Preeclampsia (PE) is a multi-system disorder of human pregnancy characterized by hypertension and proteinuria. Although its pathogenesis is not fully understood, predisposition to endothelial dysfunction is thought to play a crucial part. Normotensive pregnancy is associated with increases in coagulation factor levels and decreases in natural ...
M B, Pinheiro, K B, Gomes, L M S, Dusse
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The Fibrinolytic System in Children
Seminars in Thrombosis and Hemostasis, 2003The fibrinolytic system comprises a cascade of serine proteinase activation events that culminate in the generation of plasmin and, subsequently, degradation of fibrin. Although all components of the fibrinolytic system are present at birth, plasma concentrations of key components in infants and children differ physiologically from those in adults ...
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Aspirin and the fibrinolytic response
Thrombosis Research, 2003Apart from the anti-inflammatory action, aspirin (ASA) by inhibiting thromboxane A2 synthesis, decreases platelets activity and possesses the antithrombotic action. However, an ASA effect on fibrinolysis has not been yet finally established. Menon [Lancet 1 (1970) 364] reported increased fibrinolytic response in patients treated with high doses of ASA ...
Włodzimierz, Buczko +3 more
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Fibrinolytic Bacterial Metabolite
Nature, 1962IN the course of work on auto-antibodies in patients suffering from multiple myeloma marked fibrinolytic activity was discovered in one of the sera. Further investigation revealed that it was contaminated with two kinds of bacteria, one a member of the genus Pseudomonas, the other a strain of Streptococcus faecalis. The role of Pseudomonas was shown to
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Progress in Cardiovascular Diseases, 1979
W ITHOUT question, degenerative vascular disease remains the major cause of death and morbidity in the Western world. In the United Kingdom, cardiovascular disease is responsible for about 50% of all deaths in men aged 45-54 yr, and this must be compared with only 25% of deaths in this age group resulting from cancers.’ Although little direct proof ...
J F, Davidson, I D, Walker
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W ITHOUT question, degenerative vascular disease remains the major cause of death and morbidity in the Western world. In the United Kingdom, cardiovascular disease is responsible for about 50% of all deaths in men aged 45-54 yr, and this must be compared with only 25% of deaths in this age group resulting from cancers.’ Although little direct proof ...
J F, Davidson, I D, Walker
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Fibrinolytic activity and thromboembolism
Clinical Pharmacology & Therapeutics, 1972Fibrinolysis is reduced in acute thromboembolism. Titers of fibrinolysin inhibitor vary diurnally in the same directions and to the same degree as in the sex‐ and age‐matched normal control subject, but always within a higher range. The acute thromboembolic episode apparently involves an initial fall in inhibitor, followed by a gradual rise to an ...
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The Fibrinolytic Activity in the Newborn
Acta Paediatrica, 1958Summary The fibrinolytic activity of umbilical cord blood was investigated in 143 cases. In about half of the cases no fibrinolytic activity could be demonstrated. In the other cases there was a mild or moderate fibrinolytic activity. There was no difference in activity between the samples investigated immediately after the puncture and those kept ...
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