Results 201 to 210 of about 60,436 (245)
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Activation of the Fibrinolytic System
Cardiology Clinics, 1987The fibrinolytic system is activated either directly or indirectly by proteins that convert plasminogen to plasmin in the circulation, within the interstitices, and on the surface of fibrin clots, or both. Agents that activate circulating and clot-bound plasminogen comparably induce a systemic lytic state accompanying clot lysis.
A K, Robison, D, Collen
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Fundamentals of fibrinolytic therapy
Cardiovascular and Interventional Radiology, 1988The fibrinolytic system is activated by the conversion of plasminogen to plasmin by mediators such as tissue extract, plasma factor XII, or the exogenous activators urokinase (UK) and streptokinase (SK). The foreign protein composition of SK is responsible for the allergic response observed in some patients following administration.
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Elements of the Fibrinolytic System
Annals of the New York Academy of Sciences, 2001A bstract : The blood fibrinolytic system comprises an inactive proenzyme, plasminogen, that can be converted to the active enzyme, plasmin.
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The Fibrinolytic System in Neoplasia
Seminars in Thrombosis and Hemostasis, 1996During activation of the fibrinolytic system plasminogen is converted to plasmin by tissue plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). t-PA is predominantly released from endothelial cells, u-PA primarily by renal parenchymal cells. The activation of plasminogen is regulated by plasminogen activator inhibitor-1 (PAI-1),
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Pharmacology of fibrinolytic agents
Progress in Cardiovascular Diseases, 1979T HE appreciation of the high morbidity and mortality from thromboembolic occlusive vascular disease has given the impetus to a continuing search for drugs that might be of clinical value in its prevention and treatment. Anticoagulant therapy with heparin or the oral anticoagulants is primarily prophylactic, and while these drugs can prevent the ...
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[Fibrinolytic and defibrinogenation therapy].
La Ricerca in clinica e in laboratorio, 1983Plasma fibrinogen is one of the main determinants of blood viscosity and is known to play an important role in the pathogenesis of venous and arterial thromboembolism. The pharmacological intervention on these factors can be achieved by lowering fibrinogen. Plasma fibrinogen concentrations can be lowered by fast-acting and slow-acting drugs. Among fast-
D. Mari, P.M. Mannucci
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