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Tenecteplase: A fibrinolytic agent
British Journal of Cardiac Nursing, 2006Thrombolysis is an established therapy for acute myocardial infarction in the UK. ST-elevation myocardial infarction almost always occurs owing to coronary atherosclerosis and coronary thrombosis which develops because of plaque disruption. Fibrinolytic agents act to dissolve the clot.
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Local Release of Fibrinolytic Agents for Adhesion Prevention
Journal of Surgical Research, 1995Tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and streptokinase were evaluated for their ability to reduce postsurgical adhesion formation in a rat uterine horn devascularization and serosal injury model in a blinded, randomized study.
J L, Hill-West, R C, Dunn, J A, Hubbell
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1978
The prophylaxis and treatment of thromboembolic disorders have long involved the use of anticoagulants administered either parenterally or via the oral route. However, at the present time, there is no longer unanimity regarding the effectiveness of this medication, due to the difficulties of objective assessment of all of the parameters of ...
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The prophylaxis and treatment of thromboembolic disorders have long involved the use of anticoagulants administered either parenterally or via the oral route. However, at the present time, there is no longer unanimity regarding the effectiveness of this medication, due to the difficulties of objective assessment of all of the parameters of ...
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Pharmacokinetics and Pharmacodynamics of Fibrinolytic Agents
2015In this chapter, the historical development, as well as, pharmacokinetics and pharmacological properties of the more frequently used fibrinolytic agents in pulmonary embolism patients, namely streptokinase, alteplase, and tenecteplase are analyzed. The historical development of the first-, second-, and third-generation fibrinolytics has been reviewed ...
Carlos Jerjes-Sánchez +1 more
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Acyl-Enzymes As Fibrinolytic Agents
Thrombosis and Haemostasis, 1981Plasminogen activators or plasmins specifically and reversibly acylated at the active centre have been used as delivery systems for fibrinolytic agents in vivo. Potential advantages of this approach, including enhanced efficacy, reduced toxicity and better control of lysis are discussed.
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[Fibrinolytics and defibrinating agents].
Phlebologie, 1976Therapeutic fibrinolysis represents the only logical means of curing thromboses, by assuring the destruction of the thrombus. This kind of therapy, which was introduced clincally over 10 years ago, has been used on only a limited scale because of the high risk of haemorrhage and the need for highly specialized laboratory control tests.
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Synthetic Fibrinolytic Agents Induction of Fibrinolytic Activity In Vitro
1978Various asymmetric organic anions have been shown to possess the important capacity to enhance the endogenous fibrinolytic activity in human plasma in vitro. Their further development may well permit induction with them of the thrombolytic activity in human blood in vivo resulting in intravascular clot (thrombi, emboli) dissolution (thrombolysis) by ...
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Managing anticoagulation and fibrinolytic agents
2002Abstract Anticoagulants and thrombolytic agents are widely used in many branches of medicine. These agents can be truly life-saving, but there is a narrow therapeutic margin and they can cause serious haemorrhagic complications.
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