Results 91 to 100 of about 4,924,739 (173)

Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis

主査 : 亀田秀人 / タイトル : Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis /著者 : Hiroshi Sato, Sei Muraoka, Natsuko Kusunoki, Shotaro Masuoka, Soichi Yamada, Hideaki Ogasawara, Toshio Imai ...
佐藤, 洋志, サトウ, ヒロシ, Sato, Hiroshi   +2 more
core   +1 more source

Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains

, 2001
Udgivelsesdato: 2001-Feb-15Membrane peptidases play important roles in cell activation, proliferation and communication. Human fibroblast-like synoviocytes express considerable amounts of aminopeptidase N/CD13, dipeptidyl peptidase IV/CD26, and ...
Riemann, D, Santos, A N, Danielsen, E M, Niels-Christiansen, L, Immerdal, Lissi, Thorsen, Evy, Kehlen, A, Langner, J, Hansen, Gert Helge   +8 more
core   +1 more source

Fibroblast-like synoviocyte-chondrocyte interaction in cartilage degradation

, 2007
Objective: In vitro models for joint diseases often focus on a single cell type, such as chondrocytes in osteoarthritis (OA) or fibroblast-like synoviocytes (synoviocytes) in rheumatoid arthritis (RA). However, these joint diseases affect the whole joint
Ronday, H.K., Huizinga, T.W.J., Steenvoorden, M.M.C., Bank, R.A., Groot, J. de, Toes, R.E.M.   +5 more
core  

siRNA therapy in osteoarthritis: targeting cellular pathways for advanced treatment approaches

Frontiers in Immunology
Osteoarthritis (OA) is a common joint disorder characterized by the degeneration of cartilage and inflammation, affecting millions worldwide. The disease’s complex pathogenesis involves various cell types, such as chondrocytes, synovial cells ...
Yunshen Li, Yunshen Li, Yunshen Li, Jianan Zhao, Jianan Zhao, Jianan Zhao, Shicheng Guo, Dongyi He, Dongyi He, Dongyi He   +9 more
doaj   +1 more source

CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis

Journal of Orthopaedic Translation
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and bone destruction. Abnormal TNF/TNFR signaling leads to various dysregulations in Fibroblast-like synoviocytes (FLSs), including proliferation,
Xiaomeng Luo, Lingling Xu, Juan Cai, Siyang Ma, Haining Song, Pingting Yang, Chunshu Yang   +6 more
doaj   +1 more source

PHARMACOLOGICAL CHARACTERIZATION OF PURINE RECEPTORS IN BOVINE AND HUMAN CHONDROCYTES AND FIBROBLAST-LIKE SYNOVIOCYTES.

, 2010
Chronic inflammation is an important factor in the pathology of different forms of joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA).
TOSI, Alice
core  

ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis

Arthritis Research & Therapy
Objective Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) phenotype leads to an imbalance in the synovial inflammatory ...
Kai Chen, Huaqiang Tao, Pengfei Zhu, Miao Chu, Xueyan Li, Yi Shi, Liyuan Zhang, Yaozeng Xu, Shujun Lv, Lixin Huang, Wei Huang, Dechun Geng   +11 more
doaj   +1 more source

Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint

Journal of Translational Autoimmunity
Objective: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) alter their metabolism to support their activation. We aimed to analyse the full spectrum of metabolic alterations associated with RA by performing untargeted metabolomics in RA ...
Georgios K. Vasileiadis, Yuan Zhang, Marion Laudette, Tahzeeb Fatima, Anna-Karin Hultgård Ekwall, Reshmi Sureshkumar, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Gröndal, Kim Hørslev-Petersen, Kristina Lend, Merete L. Hetland, Michael Nurmohamed, Mikkel Østergaard, Till Uhlig, Tuulikki Sokka-Isler, Anna Rudin, Jan Borén, Monica Guma, Cristina Maglio   +22 more
doaj   +1 more source

The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

, 2018
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3′-untranslated region (UTR) of target mRNAs.
Wenming Hong, Pengying Zhang, Xinming Wang, Wei Wei, Jiajie Tu   +4 more
core   +1 more source

Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes

Rheumatoid arthritis (RA) is a prevalent autoimmune disorder primarily targeting the diarthrodial joints. During the progression of RA, fibroblast-like synoviocytes (FLSs) exhibit tumor-like behavior, including increased proliferation, inflammation ...
Yang Luo, Hai-Li Shen, Li Zhang
core   +1 more source