Results 71 to 80 of about 4,924,739 (173)

MARCH5 Links Hypoxia to Neutrophil Ferroptosis in SLE via FSP1 Ubiquitination

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
ABSTRACT Purpose Ferroptosis plays an important role in the progression of systemic lupus erythematosus (SLE). This study aims to investigate the molecular mechanism by which membrane‐associated RING‐CH‐type finger protein 5 (MARCH5) regulates ferroptosis suppressor protein 1 (FSP1), a key regulator of ferroptosis resistance, under hypoxic conditions ...
Jing Zhang, Fulin Cai, Jiansen Lu, Zhiwei Liu   +3 more
wiley   +1 more source

Pharmacological characterization of purine receptors in bovine fibroblast-like synoviocytes

, 2009
Growing evidence also suggests that extracellular nucleotides, acting through purinergic receptors, play a central role in the regulation of bone and cartilage metabolism.
GESSI, Stefania, CARUSO, Angelo, BOREA, Pier Andrea, VINCENZI, Fabrizio, VARANI, Katia, DE MATTEI, Monica, MERIGHI, Stefania   +6 more
core  

tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis [PDF]

, 2004
Abnormalities in the p53 tumor suppressor gene have been detected in rheumatoid arthritis (RA) and could contribute to the pathogenesis of chronic disease.
Alison Connor, Green, Douglas R, Zollman, Susan, Connor, Alison, Yuji Yamanishi, Gary S Firestein, Susan Zollman, Douglas R Green, Edward C Keystone, Firestein, Gary S, Keystone, Edward C, David L Boyle, Boyle, David L, Yamanishi, Yuji   +13 more
core   +1 more source

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

Nature Communications, 2016
Rheumatoid arthritis is an inflammatory disease that selectively affects different joints. Here the authors show that gene expression and DNA methylation patterns of fibroblast-like synoviocytes differ between hip and knee joints in patients with RA ...
Rizi Ai, Deepa Hammaker, David L. Boyle, Rachel Morgan, Alice M. Walsh, Shicai Fan, Gary S. Firestein, Wei Wang   +7 more
doaj   +1 more source

Estrogen Receptor Expression Changes After Puberty in the Porcine Anterior Cruciate Ligament

Journal of Orthopaedic Research, Volume 44, Issue 11, November 2026.
Schematic highlighting the study design and approach to characterize genetic differences and hormone receptor expression differences between the AM and PL bundles across growth. Pre‐ and post‐pubescent female pigs had their ACLs removed, separated by bundle, and then characterized using gene expression, western blot, and immunofluorescence.
Jacob D. Thompson, Margaret E. Easson, Matthew B. Fisher   +2 more
wiley   +1 more source

PHARMACOLOGICAL CHARACTERIZATION OF P2X1 AND P2X3 PURINERGIC RECEPTORS IN BOVINE CHONDROCYTES AND FIBROBLAST-LIKE SYNOVIOCYTES

, 2009
Extracellular nucleotides, acting through purinergic receptors, play a central role in the regulation of bone and cartilage metabolism. Chondrocytes within articular cartilage are responsible for the synthesis and degradation of the extracellular matrix,
TOSI, ALICE, GESSI, Stefania, BOREA, Pier Andrea, VINCENZI, Fabrizio, PELLATI, Agnese, VARANI, Katia, MERIGHI, Stefania, DE MATTEI, Monica   +7 more
core  

Effect of Miao medicine, Jinwujiangu decoction, on IL- 17/IL-23 inflammatory axis of fibroblast-like synoviocytes in rheumatoid arthritis [PDF]

, 2019
Purpose: To explore the influence of the Miao medicine, Jinwujiangu decoction, on the interleukin (IL)- 17/IL-23 inflammatory axis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA).Methods: Synovial tissue samples were randomly divided ...
Ning, Qiaoyi, Li, Rong, Lu, Daoming, Ma, Wukai, An, Yang, Yao, Xueming, Liang, Jiang, Huang, Ying, Xu, Hui, Tang, Fang   +9 more
core   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Mitomycin C Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via a Mitochondrial-Mediated Pathway [PDF]

, 2015
Background/Aims: Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterised by prominent synoviocyte hyperplasia and a potential imbalance between the growth and death of fibroblast-like synoviocytes (FLS).
Xiaojian Cao, Changhui Su, Chuqi Yan, Dong Ge, Xishan Zhang, Chuqi Yan, Yanming Zhang, Dechao Kong   +7 more
core   +1 more source

Parenteral CHIKV mRNA Vaccination Reshapes the Gut Microbial, Metabolic, and Immune Landscapes

MedComm, Volume 7, Issue 11, November 2026.
This study provides multi‐omics evidence that parenteral mRNA vaccination against CHIKV, even in the absence of viral infection, can profoundly remodel the host intestinal ecosystem—recapitulating key microbial, metabolic, and GI immune features typically associated with active CHIKV infection, characterized by enrichment of Segatella copri, activation
Hongyu Chen, Wenhao Xie, Yun Yang, Cong Tang, Xiaoming Liang, Yuxia Yuan, Junbin Wang, Yanan Zhou, Hao Yang, Qing Huang, Wenqi Quan, Wenhai Yu, Haixuan Wang, Daoju Wu, Youchun Wang, Shuaiyao Lu   +15 more
wiley   +1 more source