Results 81 to 90 of about 4,924,739 (173)

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Effects of pulsed electromagnetic field exposure on adenosine receptors in human fibroblast-like synoviocytes.

, 2011
Human fibroblast-like synoviocytes play a central role in the pathogenesis of joint destruction primarily by the secretion of a wide range of pro-inflammatory mediators including cytokines, growth factors and lipid mediators of inflammation.
Cadossi P.A., TARGA, Martina, MASSARI, Leo, BOREA, Pier Andrea, VINCENZI, Fabrizio, MASIERI, Federica Francesca, VARANI, Katia, ONGARO, Alessia, DE MATTEI, Monica, Setti S.   +9 more
core  

The LKB1–AMPK Signaling Axis Modulates Ferroptosis in Fibroblast-Like Synoviocytes Derived from Rheumatoid Arthritis

Biomedicines
Background/Objectives: Ferroptosis is a type of regulated cell death that involves iron-dependent accumulation of lipid peroxides. Because fibroblast-like synoviocytes (FLSs) in patients with rheumatoid arthritis (RA) have a hyperplastic and inflammatory
Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, Seong Wook Kang   +3 more
doaj   +1 more source

Differential effects of anti-TNF-alpha drugs on fibroblast-like synoviocyte apoptosis

, 2010
Novel drugs targeting TNF-alpha are available for treatment of RA. Fibroblast-like synoviocytes (FLSs) play a fundamental role in RA progression, through their expansion caused in part by resistance to cell death induction.
Casali, Bruno, SALVARANI, CARLO, Boiardi, Luigi, Pattacini, Laura   +3 more
core   +1 more source

mRNA expression of genes involved in inflammation and haemostasis in equine fibroblast-like synoviocytes following exposure to lipopolysaccharide, fibrinogen and thrombin [PDF]

, 2015
Background: Studies in humans have shown that haemostatic and inflammatory pathways both play important roles in the pathogenesis of joint disease. The aim of this study was to assess mRNA expression of haemostatic and inflammatory factors in cultured ...
Stine Jacobsen, Stine Mandrup Andreassen, Jacobsen, Stine, Andreassen, Stine Mandrup, Lise C. Berg, Søren Saxmose Nielsen, Annemarie T. Kristensen, Berg, Lise Charlotte, Nielsen, Søren Saxmose, Kristensen, Annemarie Thuri   +9 more
core   +1 more source

SPA0355, a thiourea analogue, inhibits inflammatory responses and joint destruction in fibroblast‐like synoviocytes and mice with collagen‐induced arthritis

, 2011
BACKGROUND AND PURPOSE NF-kappa B has been implicated as a therapeutic target for the treatment of rheumatoid arthritis. We previously synthesized a thiourea analogue, SPA0355, which suppressed NF-kappa B activity.
YJ Cheon, JH Ryu, BH Park, Lee, H. S., HS Lee, SM Lee, Cheon, Y. J., Lee, Y. R., Park, J. W., Hwang, J. K., Lee, S. I., Jeon, R., SI Lee, Kwak, H. B., JW Park, YR Lee, HB Kwak, R Jeon, Park, B. H., Ryu, J. H., Lee, S. M., JK Hwang, JS Kim, Kim, J. S.   +23 more
core   +1 more source

Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes. [PDF]

, 2017
Platelet-derived microparticles (PMPs) are closely associated with disease activity in rheumatoid arthritis (RA) and contribute to the inflammatory process.
Zhongshuang Ma, Binzhou Yang, Jiahuan Liu, Guiping Liu, Yu Zhang, Weigan Shen, Wenwen Wang   +6 more
core   +1 more source

LAIR-1 shedding from human fibroblast-like synoviocytes in rheumatoid arthritis following TNF-α stimulation

, 2018
Summary This study examined the expression of the inhibitory receptor, leucocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients to investigate its ...
X Yi, X Liu, Y Ding, J Zhang, H Dong, R Zhuang, S Wang, Y Zhang   +7 more
core   +1 more source

Immunological Roles of Fibroblast-Like Synoviocyte Cells in Rheumatoid Arthritis [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Fibroblast-like synoviocytes (FLS), also known as synovial fibroblasts or type B synoviocytes, are the primary cells responsible for the structure of the synovial lining.
Mohammad Reza Royaei, Mohammad Taher Tahoori   +1 more
doaj  

Functional expression of the chemokine receptor CCR7 on fibroblast-like synoviocytes

, 2008
Objectives. We have characterized the expression and the function of the chemokine receptor CCR7 on fibroblast-like synoviocytes (FLS) of patients with RA and OA and on dermal fibroblasts. Methods.
Schölmerich, J., Brühl, H., Lochbaum, D., Straub, R. H., Mack, M., Niedermeier, M.   +5 more
core   +1 more source