Results 1 to 10 of about 8,715 (97)
Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis. [PDF]
Open BiolRheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role of FLS circadian clock function in directing rhythmic joint inflammation in a ...
Downton P +4 more
europepmc +7 more sources
Targeting fibroblast-like synoviocytes in rheumatoid arthritis [PDF]
Current Opinion in Pharmacology, 2022 Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role in the physiology of the synovium by producing certain components of the synovial fluid and articular cartilage. In rheumatoid arthritis (RA), however, fibroblasts become a key driver of synovial inflammation and joint damage.
Vladislav Tsaltskan, Gary S. Firestein
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Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes [PDF]
Inflammation, 2020 Abstract Osteoarthritis (OA) is considered the most frequent degenerative disease and is characterized by cartilage degradation and synovial inflammation. Fibroblast-like synoviocytes (FLSs) are vital to synovial inflammation in OA. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and hyperinsulinemia (HINS) and has been ...
Li Qiao, Yi Li, Shui Sun
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Simvastatin Induces Apoptosis of Fibroblast-Like Synoviocytes [PDF]
The Open Rheumatology Journal, 2009 Background: Statins (3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors) exert favorable effects on lipoprotein metabolism, but appeared to possess anti-inflammatory properties among others, as suggested by their ability to inhibit collagen-induced arthritis in mice.
Litinsky, Ira +5 more
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Epigenetic Alterations in Rheumatoid Arthritis Fibroblast-Like Synoviocytes [PDF]
Epigenomics, 2017 Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes.
Doody, Karen M +2 more
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CCL22 induces pro-inflammatory changes in fibroblast-like synoviocytes [PDF]
iScience, 2021 Synovitis is common in patients with osteoarthritis (OA) and is associated with pain and disease progression. We have previously demonstrated that the chemokine C-C motif chemokine 22 (CCL22) induces chondrocyte apoptosis in vitro; however, the effects of CCL22 on the synovium remain unknown.
Guomin Ren +4 more
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The synovial proteome: analysis of fibroblast-like synoviocytes [PDF]
Arthritis Res Ther, 2004 The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by matrix-assisted laser desorption ...
Dasuri, Kumar +7 more
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Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]
Arthritis Research & Therapy, 2001 An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R alpha-chain and beta-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long ...
Möller, Burkhard +7 more
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IFN-gamma promotes fibroblast-like synoviocytes motility [PDF]
Annals of the Rheumatic Diseases, 2010 Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease. In RA, a systemic autoimmune response translates into an inflammatory attack on the synovium that yields the formation of an aggressive cell mass called pannus which attaches to, encroaches over and destroys the articular cartilage.
T Karonitsch +8 more
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Fibroblast-Like Synoviocytes Induce Calcium Mineral Formation and Deposition [PDF]
Arthritis, 2014 Calcium crystals are present in the synovial fluid of 65%–100% patients with osteoarthritis (OA) and 20%–39% patients with rheumatoid arthritis (RA). This study sought to investigate the role of fibroblast-like synoviocytes (FLSs) in calcium mineral formation.
Yubo Sun +6 more
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