Results 11 to 20 of about 8,735 (117)

PUMA regulation and proapoptotic effects in fibroblast‐like synoviocytes [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveAlthough p53 is overexpressed in rheumatoid arthritis (RA) synovial tissue (ST), few synoviocytes undergo apoptosis. This could be partly due to low expression of proapoptotic genes. Deficient p53 up‐regulated modulator of apoptosis (PUMA), which is a major effector of p53‐mediated cell death, could contribute to this phenomenon.
Hoon-Suk, Cha, Sanna, Rosengren, David L, Boyle, Gary S, Firestein   +3 more
openaire   +2 more sources

Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes [PDF]

Journal of Immunology Research, 2019
Objective. Iguratimod, a novel disease-modifying anti-rheumatic drug for the treatment of rheumatoid arthritis, has been approved in China and Japan. Here, we aimed to find whether iguratimod can inhibit the aggressive behavior and promote apoptosis of rheumatoid fibroblast-like synoviocytes (RA-FLSs). Methods. The proliferation of RA-FLSs was assessed
Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen   +12 more
openaire   +3 more sources

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes [PDF]

Nature Communications, 2018
AbstractEpigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS), including histone modifications (H3K27ac, H3K4me1, H3K4me3, H3K36me3, H3K27me3, and H3K9me3), open chromatin, RNA expression and whole ...
Ai, Rizi, Laragione, Teresina, Hammaker, Deepa, Boyle, David L, Wildberg, Andre, Maeshima, Keisuke, Palescandolo, Emanuele, Krishna, Vinod, Pocalyko, David, Whitaker, John W, Bai, Yuchen, Nagpal, Sunil, Bachman, Kurtis E, Ainsworth, Richard I, Wang, Mengchi, Ding, Bo, Gulko, Percio S, Wang, Wei, Firestein, Gary S   +18 more
openaire   +5 more sources

Editorial: Immunomodulatory roles of fibroblast-like synoviocytes in rheumatoid arthritis. [PDF]

Front Immunol
Chen Y, Han T, Guo Z, Li X, Zhang X, Peng W.   +5 more
europepmc   +4 more sources

Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis [PDF]

Immunological Reviews, 2009
Summary: Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant therapeutic advances. The pathogenesis of RA is complex and includes many cell types, including T cells, B cells, and macrophages. Fibroblast‐like synoviocytes (FLS) in the synovial intimal lining also play a key role by producing cytokines that perpetuate ...
Beatrix, Bartok, Gary S, Firestein
openaire   +2 more sources

Pathological role of fibroblast‐like synoviocytes in charcot neuroarthropathy [PDF]

Journal of Orthopaedic Research, 2015
ABSTRACTThis study was designed to characterize the synovium in the joints of Charcot neuroarthropathy (CNA) and investigate the potential role of fibroblast‐like synoviocytes (FLS) in the pathology of CNA. Synovial samples were collected from CNA patients (n = 7) and non‐CNA patients (n = 7), for control, during orthopaedic procedures and used for ...
Jeremy, Molligan, Cameron, Barr, Reed, Mitchell, Lew, Schon, Zijun, Zhang   +4 more
openaire   +2 more sources

Cadherin 11 promotes invasive behavior of fibroblast‐like synoviocytes [PDF]

Arthritis & Rheumatism, 2009
AbstractObjectiveTo define the expression pattern of cadherin 11 in the destructive pannus tissue of patients with rheumatoid arthritis, and to determine whether cadherin 11 expression in fibroblast‐like synoviocytes controls their invasive capacity.MethodsCadherin 11 expression in rheumatoid synovial tissue was evaluated using immunohistochemistry. To
Hans P, Kiener, Birgit, Niederreiter, David M, Lee, Esther, Jimenez-Boj, Josef S, Smolen, Michael B, Brenner   +5 more
openaire   +2 more sources

FRI0033 Erythropoietin-receptor-expression in fibroblast-like synoviocytes [PDF]

Annals of the Rheumatic Diseases, 2001
Background The anaemia of chronic disease in patients with rheumatoid arthritis (RA) can be corrected by treatment with recombinant human erythropoietin (rHu-Epo). In addition to an increase of haemoglobin concentration during therapy with rHu-Epo, a significant reduction of disease activity was observed in different RA-studies.
U Kessler, S Woelfer, N Kukoc-Zivojnov, JP Kaltwasser, B Moeller   +4 more
openaire   +1 more source

CCL18 Activates Fibroblast-like Synoviocytes in Patients with Rheumatoid Arthritis [PDF]

The Journal of Rheumatology, 2013
To the Editor: Fibroblast-like synoviocytes (FLS) proliferate in the synovial tissue of patients with rheumatoid arthritis (RA), and contribute to chronic inflammation and the destruction of articular cartilage due to the production of a variety of cytokines, chemokines, and matrix metalloproteinases (MMP)1.
Aiko, Takayasu, Yoshishige, Miyabe, Waka, Yokoyama, Kayoko, Kaneko, Shin, Fukuda, Nobuyuki, Miyasaka, Chie, Miyabe, Tetsuo, Kubota, Toshihiro, Nanki   +8 more
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TRIM32 promotes inflammatory responses in rheumatoid arthritis fibroblast‐like synoviocytes [PDF]

Scandinavian Journal of Immunology, 2020
AbstractRheumatoid arthritis (RA) is a worldwide autoimmune disease. The study of its aetiology and mechanism has always been a focus topic in medicine. This research was designed to investigate the effect of E3 ubiquitin ligase tripartite motif protein 32 (TRIM32) in rheumatoid arthritis (RA).
Tian Liang, Min Song, Kewu Xu, Chenglong Guo, Hongbin Xu, Hongwei Zhang, Lanping Xu   +6 more
openaire   +2 more sources