Results 21 to 30 of about 8,735 (117)

Biological Effects of Phosphate on Fibroblast-Like Synoviocytes [PDF]

ISRN Cell Biology, 2012
This study sought to examine the expression of genes implicated in phosphate transport and pathological calcification in osteoarthritis (OA) and rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and investigate the biological effects of phosphate.
Yubo Sun, David R. Mauerhan, Deepthi Chaturvedi, Edward N. Hanley, Helen E. Gruber   +4 more
openaire   +1 more source

Regulation of JNK by MKK‐7 in fibroblast‐like synoviocytes [PDF]

Arthritis & Rheumatism, 2006
AbstractObjectiveJNK regulates matrix metalloproteinase (MMP) gene expression and joint destruction in rheumatoid arthritis (RA). Previous studies demonstrated that the 2 upstream MAPK kinases (MKK‐4 and MKK‐7) are phosphorylated in RA synovium and form a complex with JNK in fibroblast‐like synoviocytes (FLS). However, the functional hierarchy of MKK‐4
Tomoyuki, Inoue, Deepa, Hammaker, David L, Boyle, Gary S, Firestein   +3 more
openaire   +2 more sources

Cadherin-11 Provides Specific Cellular Adhesion between Fibroblast-like Synoviocytes [PDF]

The Journal of Experimental Medicine, 2004
Cadherins are integral membrane proteins expressed in tissue-restricted patterns that mediate homophilic intercellular adhesion. During development, they orchestrate tissue morphogenesis and, in the adult, they determine tissue integrity and architecture. The synovial lining is a condensation of fibroblast-like synoviocytes (FLS) and macrophages one to
Valencia, Xavier, Higgins, Jonathan M.G., Kiener, Hans P., Lee, David M., Podrebarac, Theresa A., Dascher, Christopher C., Watts, Gerald F.M., Mizoguchi, Emiko, Simmons, Barry, Patel, Dhavalkumar D., Bhan, Atul K., Brenner, Michael B.   +11 more
openaire   +2 more sources

Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes

Frontiers in Immunology, 2022
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption. Metabolic changes in fibroblast-like synoviocytes (FLS) likely contribute to FLS abnormal response and strongly contribute to joint destruction. These changes often involve increased expression of nutrient transporters to meet a high demand for energy or ...
Alyssa Torres, Brian Pedersen, Brian Pedersen, Monica Guma, Monica Guma, Monica Guma   +5 more
openaire   +4 more sources

Matrix-mediated activation of murine fibroblast-like synoviocytes

Experimental Cell Research
Fibroblast-like synoviocytes (FLS) are key cells promoting cartilage damage and bone loss in rheumatoid arthritis (RA). They are activated to assume an invasive and migratory phenotype. While mechanisms of FLS activation are unknown, evidence suggests that pre-damaged extracellular matrix (ECM) of the cartilage can trigger FLS activation.
Isabel Zeinert, Luisa Schmidt, Till Baar, Giulio Gatto, Anna De Giuseppe, Adelheid Korb-Pap, Thomas Pap, Esther Mahabir, Frank Zaucke, Bent Brachvogel, Marcus Krüger, Thomas Krieg, Beate Eckes   +12 more
openaire   +2 more sources

Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2011
Abstract Introduction Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the expression of chemerin and ChemR23 in the synovium of rheumatoid arthritis (RA) patients and the stimulatory effects of ...
Kaneko, Kayoko, Miyabe, Yoshishige, Takayasu, Aiko, Fukuda, Shin, Miyabe, Chie, Ebisawa, Masashi, Yokoyama, Waka, Watanabe, Kaori, Imai, Toshio, Muramoto, Kenzo, Terashima, Yuya, Sugihara, Takahiko, Matsushima, Kouji, Miyasaka, Nobuyuki, Nanki, Toshihiro   +14 more
openaire   +2 more sources

Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2017
An increasing number of studies show how changes in intracellular metabolic pathways alter tumor and immune cell function. However, little information about metabolic changes in other cell types, including synovial fibroblasts, is available. In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are the most common cell type at the pannus ...
Marta F. Bustamante, Ricard Garcia-Carbonell, Katrijn D. Whisenant, Monica Guma   +3 more
openaire   +4 more sources

Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis

Arthritis Research & Therapy
AbstractFibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promising new therapeutic targets in RA.
Hongyan Qian, Chaoqiong Deng, Shiju Chen, Xinwei Zhang, Yan He, Jingying Lan, Aodi Wang, Guixiu Shi, Yuan Liu   +8 more
openaire   +3 more sources

Glycophenotyping of osteoarthritic fibroblast-like synoviocytes [PDF]

Osteoarthritis and Cartilage, 2020
S. Toegel, J. Führer, K.M. Pichler, H.-J. Gabius, B. Kubista, L. Martelanz, R. Windhager, F. Altmann   +7 more
openaire   +1 more source

Orexin A may suppress inflammatory response in fibroblast-like synoviocytes

Biomedicine & Pharmacotherapy, 2018
Orexins are peptides found in the hypothalamus and other peripheral tissues including adipose tissue, the endocrine cells of the gut, adrenal gland testis, and the pancreas. They play important roles in neuro-protection by inhibiting oxidative stress and inflammatory response via their type 1 and 2 receptors (OX1R and OX2R). The expressions of OX1R and
Minghui, Sun, Weijun, Wang, Qing, Li, Tao, Yuan, Wenjie, Weng   +4 more
openaire   +2 more sources