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Fibroblast Activation Protein Inhibitor, a Promising Radiotracer in Fibrogenesis [PDF]

C28. FROM OMICS TO EX VIVO MODELS: A ROAD MAP FOR NOVEL THERAPIES IN LUNG FIBROSIS, 2023
info:eu-repo/semantics ...
Lavis, Philomène, Pingitore, Julien, Doumont, Gilles, Gabaret, Ani, Van Simaeys, Gaëtan, Lacroix, Simon, Passon, Nicolas, Van Heymbeek, Christophe, De Maeseneire, Coraline, Huaux, François, Decaestecker, Christine, Salmon, Isabelle, Cardozo, Alessandra K, Goldman, Serge, Bondue, Benjamin   +14 more
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Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Bioorganic and Medicinal Chemistry Letters, 2021
Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer.
In Su Kim, Prithwish Ghosh
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Fibroblast Activation Protein Inhibitor PET in Pancreatic Cancer

PET Clinics, 2023
Radiolabeled fibroblast activation protein inhibitor (FAPI) has been introduced as a promising PET tracer for imaging of pancreatic cancer. To date, FAPI PET/computed tomography (CT) has generally but not universally yielded higher radiotracer uptake and tumor-to-background contrast than 18F-fluorodeoxyglucose PET/CT in primary tumors, involved lymph ...
Liang Zhao, Yizhen Pang, Long Sun, Qin Lin, Hua Wu, Haojun Chen   +5 more
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Fibroblast Activation Protein Inhibitor Theranostics

PET Clinics, 2023
Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Tadashi Watabe   +3 more
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Fibroblast Activation Protein Inhibitor (FAPI)-PET Imaging in Sarcoma

PET Clinics, 2023
Advances in histopathologic and molecular genetic subtyping of sarcoma will potentially allow identification of novel diagnostic and therapeutic targets for specific subtypes, but a "pan-sarcoma" target is needed. This article provides an overview on expression of one potential candidate, fibroblast activation protein alpha in soft tissue and bone ...
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Fibroblast Activation Protein Inhibitor PET/CT

Clinical Nuclear Medicine, 2020
Purpose Fibroblast activation protein (FAP) is a cell membrane–bound serine peptidase, overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound healing/inflammatory sites. Recently, molecular PET/CT imaging with radiolabeled FAP inhibitor (FAPI) has been evaluated in different diseases.
Punit, Sharma, Shashank Shekhar, Singh, Shankaramurthy, Gayana   +2 more
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Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein

Journal of Medicinal Chemistry, 2017
Proteases are directly involved in cancer pathogenesis. Expression of fibroblast activation protein (FAP) is upregulated in stromal fibroblasts in more than 90% of epithelial cancers and is associated with tumor progression. FAP expression is minimal or absent in most normal adult tissues, suggesting its promise as a target for the diagnosis or ...
Petra Dvořáková, Petr Bušek, Tomáš Knedlík, Jiří Schimer, Tomáš Etrych, Libor Kostka, Lucie Stollinová Šromová, Vladimír Šubr, Pavel Šácha, Aleksi Šedo, Jan Konvalinka   +10 more
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Radiation Therapy Planning Using Fibroblast Activation Protein Inhibitor

PET Clinics, 2023
Computed tomography (CT), MR imaging, and PET with fluorodeoxyglucose F18/CT are commonly used for radiation therapy planning; however, issues including precise nodal staging on CT or false positive results on PET/CT limit their usability. Clinical trials using fibroblast activation protein ligands for additional imaging have provided promising results
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Fibroblast activation protein-specific inhibitor imaging in heart failure

European Heart Journal, 2023
Abstract Background Although myocardial fibrosis can be quantified by magnetic resonance (MR), assessment of fibrosis activity is important as this will inform disease activity and the presence of ongoing adverse cardiac remodelling.
S Joshi, K Loganath, A K Barton, M R Dweck, D E Newby   +4 more
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Radiomolecular Theranostics With Fibroblast-Activation-Protein Inhibitors and Peptides

Seminars in Nuclear Medicine
The advancement of theranostics, which combines therapeutic and diagnostic capabilities in oncology, has significantly impacted cancer management. This review explores fibroblast activation protein (FAP) expression in the tumor microenvironment (TME) and its association with various malignancies, highlighting its potential as a theranostic marker for ...
Richard P. Baum, Emil Novruzov, Tianzhi Zhao, Lukas Greifenstein, Vivianne Jakobsson, Elisabetta Perrone, Aditi Mishra, Aleksandr Eismant, Kriti Ghai, Ortwin Klein, Bastian Jaeschke, Daniel Benz-Zils, Jens Cardinale, Yuriko Mori, Frederik L. Giesel, Jingjing Zhang   +15 more
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