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Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis [PDF]

Cytokine & Growth Factor Reviews, 2005
Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins.
PRESTA, Marco, DELL'ERA, Patrizia, MITOLA, Stefania Maria Filomena, MORONI, Emanuela, RONCA, Roberto, RUSNATI, Marco   +5 more
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Fibroblast Growth Factors in Depression [PDF]

Frontiers in Pharmacology, 2019
Major depressive disorder (MDD) is one of the most serious diseases and now becomes a major public health problem in the world. The pathogenesis of depression remains poorly understood. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and ...
Zheng Deng, Sheng Deng, Sheng Deng, Mu-Rong Zhang, Mu-Rong Zhang, Mu-Rong Zhang, Mi-Mi Tang, Mi-Mi Tang   +7 more
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Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage

Neural Regeneration Research, 2023
Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer’s disease mouse models and patients, and that it plays a vital role in the learning and memory.
Ruo-Meng Li, Lan Xiao, Ting Zhang, Dan Ren, Hong Zhu   +4 more
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Molecular description of fibroblast growth factor and mechanisms by which fibroblast growth factor-21 mediating biological actions and acting as a biologic biomarker of cardiovascular diseases

Indian Journal of Health Sciences and Biomedical Research KLEU, 2020
Fibroblast growth factor (FGF) family members are mostly secreted as signaling proteins with diverse functions in development and metabolism. FGFs can be classified as intracellular, paracrine, and endocrine FGFs by their action mechanisms.
Leta Shiferaw Melaku, Negeri Debela
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Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct

Animals, 2021
The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo, Maria Rosa Rebordão, Ana Amaral, Carina Fernandes, António Galvão, Elisabete Silva, Pedro Pessa-Santos, Graça Alexandre-Pires, Rosário P. Roberto da Costa, Dariusz J. Skarzynski, Graça Ferreira-Dias   +10 more
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Conversion of a Paracrine Fibroblast Growth Factor into an Endocrine Fibroblast Growth Factor [PDF]

Journal of Biological Chemistry, 2012
FGFs 19, 21, and 23 are hormones that regulate in a Klotho co-receptor-dependent fashion major metabolic processes such as glucose and lipid metabolism (FGF21) and phosphate and vitamin D homeostasis (FGF23). The role of heparan sulfate glycosaminoglycan in the formation of the cell surface signaling complex of endocrine FGFs has remained unclear. Here
Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, Ma J, Gai W, Kuro-o M, Razzaque MS, Mohammadi M   +10 more
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Fibroblast Growth Factor 2—A Review of Stabilisation Approaches for Clinical Applications

Pharmaceutics, 2020
Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/
Leah Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim   +3 more
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Role of Rhodomyrtus tomentosa (Aiton) Hassk. in regulating the expression of fibroblast growth factor family in the liver of rat in a breast cancer model [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Cellular abnormalities in the ducts and breast tissue cause breast cancer to invade nearby tissues like the liver. The fibroblast growth factor (FGF) signals are sent to its receptor and regulate various cellular processes to maintain liver ...
Putri Cahaya Situmorang, Syafruddin Ilyas, Rony Abdi Syahpura, Reka Mustika Sari, Alexander Patera Nugraha, Alek Ibrahim, Cheryl Grace Pratiwi Rumahorbo   +6 more
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Fibroblast growth factors [PDF]

Current Biology, 2003
What are they? Fibroblast growth factors (FGFs) are a family of small (20–30kDa) intercellular signalling proteins which are frequently found to be glycosylated. The first draft of the human genome identified 29 potential FGF genes, and so far transcripts have been identified for 23 of them.
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Fibroblast growth factors. [PDF]

Genome biology, 2001
Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17 to 34 kDa and share 13-71% amino acid identity.
Nobuyuki Itoh, David M. Ornitz
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