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Fibroblast growth factor-2

The International Journal of Biochemistry & Cell Biology, 2000
Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e.
M A, Nugent, R V, Iozzo
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Fibroblast growth factor-2 and cardioprotection

Heart Failure Reviews, 2007
Boosting myocardial resistance to acute as well as chronic ischemic damage would ameliorate the detrimental effects of numerous cardiac pathologies and reduce the probability of transition to heart failure. Experimental cardiology has pointed to ischemic and pharmacological pre- as well as post-conditioning as potent acute cardioprotective ...
Elissavet, Kardami   +6 more
openaire   +2 more sources

FIBROBLAST GROWTH FACTOR 1 AND FIBROBLAST GROWTH FACTOR 2 IMMUNOREACTIVITY IN GASTROINTESTINAL TUMOURS

The Journal of Pathology, 1997
Acidic and basic fibroblast growth factors (FGF-1 and FGF-2) are mitogenic polypeptides that may play a role in autocrine and paracrine growth control of malignant tumours. We have examined the expression of FGF-1 and FGF-2 in a series of 41 colorectal tumours (24 adenomas, 17 adenocarcinomas) and 50 gastric adenocarcinomas (23 intestinal, 27 diffuse),
I, el-Hariry, M, Pignatelli, N, Lemoine
openaire   +2 more sources

Affibody-mediated controlled release of fibroblast growth factor 2

Journal of Controlled Release, 2022
Protein therapeutics possess high target affinity and specificity, yet short residence times, which limit their broad utility. To overcome this challenge, we used affinity interactions to modulate protein release from a hydrogel delivery vehicle thereby prolonging therapeutic availability.
Chiara, Bostock   +5 more
openaire   +2 more sources

A Glycopolymer Chaperone for Fibroblast Growth Factor-2

Bioconjugate Chemistry, 2004
Mono- and disaccharide-containing glycopolymers were synthesized by cyanoxyl-mediated polymerization of acrylamide with acrylate-derivatized mono- and disaccharides. We demonstrate that a glycopolymer bearing pendant, fully sulfated lactose units effectively replaces heparin and heparan sulfate as a molecular chaperone for fibroblast growth factor-2 ...
Ran, Guan   +4 more
openaire   +2 more sources

Engineering Fibroblast Growth Factor-2 (FGF2) Production in Cyanobacteria [PDF]

open access: possibleACS Synthetic Biology
The Fibroblast Growth Factor 2 (FGF2) is an important signaling protein that serves to activate a variety of biological processes in animal and human cells. The FGF2 comprises an uncommon β-barrel structure composed of β-pleated sheets and loops only. It functions as a multipurpose protein involved in cell growth, division, and repair.
Bharat Kumar Majhi, Anastasios Melis
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Neutralization of Fibroblast Growth Factor-2 Reduces Intraarticular Adhesions

Clinical Orthopaedics and Related Research, 2001
Adhesion is a serious complication after trauma or surgery. Because adhesion formation is essentially a fibrogenetic process, a series of growth factors are assumed to be involved in its development. If this is true, it may be possible that inhibition of the growth factor activity suppresses adhesion formation. The current study was conducted to verify
N, Fukui   +4 more
openaire   +2 more sources

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