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Physiological Actions of Fibroblast Growth Factor-23 [PDF]
Frontiers in Endocrinology, 2018 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho ...
Reinhold G. Erben
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Fibroblast Growth Factor-23—A Potential Uremic Toxin [PDF]
Toxins, 2016 Fibroblast growth factor-23 (FGF23) is a circulating member of the FGF family produced mainly by the osteocytes and osteoblasts that can act as a hormone.
Piotr Kuczera +2 more
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Phosphate and fibroblast growth factor 23 in diabetes [PDF]
Clinical Science, 2021 AbstractDiabetes is associated with a strongly elevated risk of cardiovascular disease, which is even more pronounced in patients with diabetic nephropathy. Currently available guideline-based efforts to correct traditional risk factors are only partly able to attenuate this risk, underlining the urge to identify novel treatment targets.
Amarens van der Vaart +4 more
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Biochemistry and Biophysics Reports, 2021 Fibroblast growth factor (FGF) 23 produced by the bone is the principal hormone to regulate serum phosphate level. Serum FGF23 needs to be tightly regulated to maintain serum phosphate in a narrow range.
Yuichi Takashi +8 more
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Tumor-induced osteomalacia: Easing the diagnosis with fibroblast growth factor 23
APIK Journal of Internal Medicine, 2022 Tumor-induced osteomalacia (TIO), is a rare paraneoplastic syndrome resulting in bone pain, muscle weakness, and recurrent fractures. Hypophosphatemia, hyperphosphaturia, low 1, 25 dihydroxyVitamin D, and normal serum calcium are noted.
Mala Dharmalingam, Lohit Kumbar
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Effects of Single Vitamin D Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency [PDF]
Endocrinology and Metabolism, 2017 BackgroundVitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D homeostasis as a counter regulatory ...
Dongdong Zhang +5 more
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How Fibroblast Growth Factor 23 Works [PDF]
Journal of the American Society of Nephrology, 2007 There is a discontinuum of hereditary and acquired disorders of phosphate homeostasis that are caused by either high or low circulating levels of the novel phosphaturic hormone fibroblastic growth factor 23 (FGF23). Disorders that are caused by high circulating levels of FGF23 are characterized by hypophosphatemia, decreased production of 1,25 ...
Shiguang, Liu, L Darryl, Quarles
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Fibroblast Growth Factor 23 [PDF]
Journal of the American Society of Nephrology, 2005 Although phosphate is important in skeletal mineralization, energy metabolism, and multiple enzymatic processes, little has been understood about the regulation of phosphate in health and disease until recently.
Erik A, Imel, Michael J, Econs
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Fibroblast growth factor 23, klotho and heparin
Current Opinion in Nephrology & Hypertension, 2023 Purpose of review Fibroblast growth factor (FGF) 23 is a bone-derived hormone that regulates phosphate and vitamin D metabolism by targeting the kidney. When highly elevated, such as in chronic kidney disease (CKD), FGF23 can also target the heart and induce pathologic remodeling.
Thomas, S. Madison +2 more
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Evocalcet with vitamin D receptor activator treatment for secondary hyperparathyroidism
PLoS ONE, 2022 This ad hoc analysis of a previously conducted phase 3 head-to-head comparison study of evocalcet and cinacalcet in secondary hyperparathyroidism patients undergoing maintenance hemodialysis evaluated the efficacy and safety of combined once-daily oral ...
Takashi Shigematsu +5 more
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