Biological Roles of Fibroblast Growth Factor-2* [PDF]
Endocrine Reviews, 1997 I. Introduction II. Structure of FGF-2 III. Mechanisms of Action of FGF-2: Extra- and Intracellular Signaling A. Exogenous 18-kDa FGF-2 B. Endogenous 18-kDa FGF-2 and HMW FGF-2 IV. Release of FGF-2 V. Roles of FGF-2 in Development and Differentiation in Various Organ Systems A. Mesoderm induction B. Angiogenesis C. Vessel wall D. Lung E.
Andréas Bikfalvi +3 more
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Glypican-1 drives unconventional secretion of fibroblast growth factor 2 [PDF]
eLife, 2022 Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism.
Carola Sparn +8 more
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Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation [PDF]
FEBS Open Bio, 2023 Fibroblast growth factor (FGF) signaling plays a crucial role in lung development and repair. Fibroblast growth factor 2 (FGF2) can inhibit fibrotic gene expression and suppress the differentiation of pulmonary fibroblasts (PFs) into myofibroblasts in ...
Xiangqin Tian +7 more
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Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cells. [PDF]
PLoS ONE, 2022 Heart valve disease is a growing problem worldwide. Though very common in older adults, the mechanisms behind the development of the disease aren't well understood, and at present the only therapeutic option is valve replacement.
Marcus Ground +6 more
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The Effects of Fibroblast Growth Factor-2 (FGF-2) on Achilles Tendon Injury [PDF]
Foot & Ankle Orthopaedics, 2023 Category: Basic Sciences/Biologics; Ankle Introduction/Purpose: Achilles tendon defects are a challenging problem, and there is a need for new treatments.
Yuki Fujikawa D(Orth) +3 more
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Repression of Human Fibroblast Growth Factor 2 by a Novel Transcription Factor [PDF]
Journal of Biological Chemistry, 1999 Here we describe the cloning of the regulator of fibroblast growth factor 2 (FGF-2) transcription (RFT) using a yeast one-hybrid screening with a defined motif in FGF-2 promoter as a target sequence. Overexpression of human RFT (RFT-A) reduces FGF-2 RNA and protein levels in both normal and tumor cell lines.
Tetsuya Ueba +3 more
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Fibroblast Growth Factor-2 (FGF-2) Expression in Pterygia Using Cell Spot Arrays [PDF]
Vision, 2022 Fibroblast growth factor (FGF) is a main regulator of cell differentiation, cell migration and angiogenesis in normal and abnormal conjunctiva epithelia, but specific mechanisms of its aberrant expression are yet to be investigated. In the present study,
Stylianos Mastronikolis +7 more
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Fibroblast growth factor 2 is a druggable target against glioblastoma: A computational investigation [PDF]
Frontiers in Chemistry, 2022 Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel druggable target, is used for developing potent ...
Rabeea Siddique +12 more
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Structural analysis of the stable form of fibroblast growth factor 2 – FGF2-STAB [PDF]
Journal of Structural Biology: XFibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation.
Gabin de La Bourdonnaye +7 more
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Fibroblast growth factor-2 bound to specific dermal fibroblast-derived extracellular vesicles is protected from degradation [PDF]
Scientific Reports, 2022 Fibroblast growth factor-2 (FGF2) has multiple roles in cutaneous wound healing but its natural low stability prevents the development of its use in skin repair therapies.
Isabelle Petit +12 more
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