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Fibroblast growth factor 2. [PDF]
Differentiation, 2023 Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation.
Nickle A, Ko S, Merrill AE.
europepmc +5 more sources
Fibroblast Growth Factor 2 [PDF]
Definitions, 2020 Fibroblast growth factor 2 (288 aa, ~31 kDa) is encoded by the human FGF2 gene. This protein plays a role in the regulation of cell proliferation, angiogenesis, and limb and nervous system development.
National Cancer Institute
semanticscholar +4 more sources
Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation [PDF]
FEBS Open Bio, 2023 Fibroblast growth factor (FGF) signaling plays a crucial role in lung development and repair. Fibroblast growth factor 2 (FGF2) can inhibit fibrotic gene expression and suppress the differentiation of pulmonary fibroblasts (PFs) into myofibroblasts in ...
Xiangqin Tian +7 more
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Fibroblast Growth Factor 2—A Review of Stabilisation Approaches for Clinical Applications
Pharmaceutics, 2020 Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/
Leah Benington +3 more
doaj +2 more sources
Biological roles of fibroblast growth factor-2. [PDF]
Endocrine Reviews, 1997 I. Introduction II. Structure of FGF-2 III. Mechanisms of Action of FGF-2: Extra- and Intracellular Signaling A. Exogenous 18-kDa FGF-2 B. Endogenous 18-kDa FGF-2 and HMW FGF-2 IV. Release of FGF-2 V. Roles of FGF-2 in Development and Differentiation in Various Organ Systems A. Mesoderm induction B. Angiogenesis C. Vessel wall D. Lung E.
A. Bikfalvi +3 more
semanticscholar +4 more sources
Recombinant Fibroblast Growth Factor 2 [PDF]
Definitions, 2020 A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 2 (FGF-2). Reflecting its endogenous role, therapeutic FGF-2 exhibits a wide spectrum of biological activities, including the promotion of ...
semanticscholar +2 more sources
Glypican-1 drives unconventional secretion of fibroblast growth factor 2 [PDF]
eLife, 2022 Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism.
Carola Sparn +8 more
doaj +2 more sources
Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cells. [PDF]
PLoS ONE, 2022 Heart valve disease is a growing problem worldwide. Though very common in older adults, the mechanisms behind the development of the disease aren't well understood, and at present the only therapeutic option is valve replacement.
Marcus Ground +6 more
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The Effects of Fibroblast Growth Factor-2 (FGF-2) on Achilles Tendon Injury [PDF]
Foot & Ankle Orthopaedics, 2023 Category: Basic Sciences/Biologics; Ankle Introduction/Purpose: Achilles tendon defects are a challenging problem, and there is a need for new treatments.
Yuki Fujikawa D(Orth) +3 more
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Topical fibroblast growth factor‐2 for treatment of chronic tympanic membrane perforations [PDF]
Laryngoscope Investigative Otolaryngology, 2020 Objective To determine the efficacy of fibroblast growth factor‐2 (FGF‐2) in treating chronic nonhealing tympanic membrane (TM) perforations. Method Double‐blinded, randomized placebo controlled phase 2 clinical trial for patients with chronic TM ...
Felipe Santos +9 more
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