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Recombinant Fibroblast Growth Factor 2

Definitions, 2020
A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 2 (FGF-2). Reflecting its endogenous role, therapeutic FGF-2 exhibits a wide spectrum of biological activities, including the promotion of ...

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Fibroblast Growth Factors 1 and 2 and Fibroblast Growth Factor Receptor 1 Are Elevated in Thyroid Hyperplasia [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1998
We have previously reported increased expression of fibroblast growth factor (FGF-1 and FGF-2) in benign and malignant human thyroid neoplasia. To determine the role of these factors in thyroid hyperplasia we have examined their expression in multinodular goiter and compared findings with those in normal thyroid tissue. Because the effects of FGF-1 and
John Watkinson, J. Verhaeg, Michael C. Sheppard, Jayne A. Franklyn, Stuart D. Thompson, Margaret C. Eggo   +5 more
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Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

Journal of Neuroscience, 1997
Neurons and glia are generated throughout adulthood from proliferating cells in two regions of the rat brain, the subventricular zone (SVZ) and the hippocampus.
H. Kuhn, Jü Rgen Winkler, G. Kempermann, L. Thal, F. Gage, T. Palmer, L. J. Fisher, Mireya Nadal-Vicens, Mary Lynn   +8 more
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Fibroblast growth factor 2 isoforms and cardiac hypertrophy [PDF]

Cardiovascular Research, 2004
Fibroblast growth factor 2 (FGF-2), a multifunctional polypeptide that affects cell growth and differentiation and becomes upregulated by stress, is expressed as AUG-initiated 18 kDa FGF-2 or CUG-initiated 21-34 kDa (hi-FGF-2) isoforms. Animal models have provided strong evidence that FGF-2 is essential for the manifestation of overload- and ...
Elissavet Kardami, Sarah K. Jimenez, Zhi-Sheng Jiang, Cheryl Hirst, Peter A. Cattini, Peter Zahradka, Farah Sheikh   +6 more
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FGF2 (fibroblast growth factor 2 (basic)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FGF2 (fibroblast growth factor 2 (basic)), with data on DNA, on the protein encoded, and where the gene is implicated.
MacFarlane, LA, Murphy, P
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Long Pentraxin-3 Modulates the Angiogenic Activity of Fibroblast Growth Factor-2

Frontiers in Immunology, 2018
Angiogenesis, the process of new blood vessel formation from pre-existing ones, plays a key role in various physiological and pathological conditions.
M. Presta, Eleonora Foglio, Ander Churruca Schuind, R. Ronca   +3 more
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Priming Dental Pulp Stem Cells With Fibroblast Growth Factor‐2 Increases Angiogenesis of Implanted Tissue‐Engineered Constructs Through Hepatocyte Growth Factor and Vascular Endothelial Growth Factor Secretion

Stem Cells Translational Medicine, 2016
Tissue engineering strategies based on implanting cellularized biomaterials are promising therapeutic approaches for the reconstruction of large tissue defects.
C. Gorin, G. Rochefort, Rümeyza Bascetin, Hanru Ying, J. Lesieur, J. Sadoine, Nathan Beckouche, S. Berndt, Anita Novais, M. Lesage, B. Hosten, L. Vercellino, P. Merlet, D. Ledenmat, C. Marchiol, D. Letourneur, A. Nicoletti, S. Vital, A. Poliard, B. Salmon, L. Muller, C. Chaussain, S. Germain   +22 more
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Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS

Journal of Neuroscience, 1999
During development of the mammalian brain, both neurons and glia are generated from multipotent neural stem cells. Although neurogenesis ceases in most areas at birth, stem cells continue to generate neurons within the subventricular zone and hippocampal
T. Palmer, E. Markakis, Andrew R. Willhoite, Frank Safar, F. Gage   +4 more
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Fibroblast Growth Factors 1 and 2 in the Primate Uterus [PDF]

Biology of Reproduction, 1998
Fibroblast growth factors (FGF) 1 and 2 are paracrine effectors of proliferation and angiogenesis in many tissues. To elucidate potential roles for these growth factors in uterine plasticity, we used in situ hybridization histochemistry to identify the cellular sources of FGF-1 and -2 production, and immunohistochemistry to identify the cellular and ...
Carolyn A. Bondy, Jian Zhou, Juan Wang, C.A. Samathanam, O. O. Adesanya   +4 more
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Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies

OncoTarget, 2016
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by binding to heparan sulfate and FGF receptors (FGFR) with varying affinities.
Mohamed R. Akl, Poonam Nagpal, N. Ayoub, B. Tai, S. Prabhu, Catherine M. Capac, Matthew Gliksman, A. Goy, K. S. Suh, Stephen K. Suh   +9 more
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