Fibroblast Growth Factor 2—A Review of Stabilisation Approaches for Clinical Applications
Pharmaceutics, 2020 Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/
Leah Benington +3 more
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Fibroblast Growth Factor-2 Signaling in Neurogenesis and Neurodegeneration [PDF]
Journal of Neuroimmune Pharmacology, 2013 Fibroblast growth factor-2 (FGF2), also known as basic FGF, is a multi-functional growth factor. One of the 22-member FGF family, it signals through receptor tyrosine kinases encoding FGFR1-4. FGF2 activates FGFRs in cooperation with heparin or heparin sulfate proteoglycan to induce its pleiotropic effects in different tissues and organs, which include
Tsuneya Ikezu, Maya E. Woodbury
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Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine. [PDF]
PLoS ONE, 2018 Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic and anti-depressive agent in rodents. Levels of hippocampal FGF2 and FGF2 receptors are decreased in post-mortem brains of individuals with mood disorders.
Stephanie Simard +6 more
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Effects of fibroblast growth factor-2 on cell proliferation of cementoblasts
Journal of Dental Sciences, 2016 Background/purpose: Fibroblast growth factor (FGF)-2 is known as a signaling molecule that induces tissue regeneration. Little is known about the effect of FGF-2 on cementoblasts for periodontal and periapical regeneration.
Hui-Chieh Yu +4 more
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A New 34-Kilodalton Isoform of Human Fibroblast Growth Factor 2 Is Cap Dependently Synthesized by Using a Non-AUG Start Codon and Behaves as a Survival Factor [PDF]
Molecular and Cellular Biology, 1999 Emmanuelle Arnaud +6 more
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Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2 [PDF]
, 2001 Neural stem cells (NSCs), when stimulated with epidermal growth factor (EGF) or fibroblast growth factor-2 (FGF-2), have the capacity to renew, expand, and produce precursors for neurons, astrocytes, and oligodendrocytes.
Aebischer, P. +3 more
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Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes [PDF]
Arthritis Research & TherapyDongyao Yan +6 more
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Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study
Medicina, 2021 Background and Objectives: Aortic valve stenosis (AS) develops with a pronounced local inflammatory response, where a variety of growth factors are involved in the process, and may have a pro-inflammatory and anti-inflammatory effect.
Juris Hofmanis +9 more
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Pharmaceutics, 2021 Basic fibroblast growth factor (FGF-2) is a highly labile protein with strong potential for tissue engineering. The aim of this study was to develop FGF-2 formulations that are stable against physical stressors encountered in pharmaceutical processing ...
Leah R. Benington +3 more
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Scientific Reports, 2020 In the wound healing process, the morphology of keratinocytes at the wound edge temporarily changes to a spindle morphology, which is thought to occur due to an epithelial–mesenchymal transition (EMT).
Y. Koike +3 more
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