Results 21 to 30 of about 719,747 (310)

Fibroblast growth factor-2 alters the nature of extinction [PDF]

Learning & Memory, 2011
These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not
Bronwyn M. Graham, Rick Richardson
openaire   +3 more sources

Fibroblast growth factor 2 control of vascular tone [PDF]

Nature Medicine, 1998
Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature regulation, digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes ...
John J. Duffy, Christian C. Haudenschild, Evangelia G. Kranias, Ming Zhou, Gregory P. Boivin, Roy L. Sutliff, J. Douglas Coffin, Sharon A. Pawlowski, Thomas Doetschman, Richard J. Paul, Moying Yin, Wusheng Luo, John N. Lorenz, James B. Hoying, Ling Kong   +14 more
openaire   +3 more sources

Mimicking the Bioactivity of Fibroblast Growth Factor-2 Using Supramolecular Nanoribbons

ACS Biomaterials Science & Engineering, 2017
Fibroblast growth factor (FGF-2) is a multifunctional growth factor that has pleiotropic effects in different tissues and organs. In particular, FGF-2 has a special role in angiogenesis, an important process in development, wound healing, cell survival ...
Charles M. Rubert Pérez, Z. Álvarez, Feng Chen, Taner Aytun, S. Stupp   +4 more
semanticscholar   +1 more source

Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis

Journal of Cell Biology, 1998
FGF-2 and VEGF are potent angiogenesis inducers in vivo and in vitro. Here we show that FGF-2 induces VEGF expression in vascular endothelial cells through autocrine and paracrine mechanisms. Addition of recombinant FGF-2 to cultured endothelial cells or
G. Seghezzi, Sundeep Patel, Christine J. Ren, A. Gualandris, G. Pintucci, E. Robbins, R. Shapiro, A. Galloway, D. Rifkin, P. Mignatti   +9 more
semanticscholar   +1 more source

FGFR2 (fibroblast growth factor receptor 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FGFR2 (fibroblast growth factor receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources

Thrombin‐mediated impairment of fibroblast growth factor‐2 activity [PDF]

The FEBS Journal, 2009
Thrombin generation increases in several pathological conditions, including cancer, thromboembolism, diabetes and myeloproliferative syndromes. During tumor development, thrombin levels increase along with several other molecules, including cytokines and angiogenic factors.
Totta P, De Cristofaro R, GIAMPIETRI, Claudia, Aguzzi MS, Faraone D, Capogrossi MC, Facchiano A.   +6 more
openaire   +6 more sources

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2.

Proceedings of the National Academy of Sciences of the United States of America, 1998
Basic fibroblast growth factor (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary.
S. Ortega, M. Ittmann, S. Tsang, M. Ehrlich, C. Basilico   +4 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation.

Kidney International, 2002
BACKGROUND Epithelial-mesenchymal transformation (EMT) plays an important role in embryonic development and tumorigenesis and has been described in organ remodeling during fibrogenesis.
F. Strutz, M. Zeisberg, F. Ziyadeh, Chang-qing Yang, R. Kalluri, G. Müller, E. Neilson   +6 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source