Results 21 to 30 of about 1,606,538 (419)
Intracellular trafficking of endogenous fibroblast growth factor‐2 [PDF]
The FEBS Journal, 2008 We have previously reported how the release of fibroblast growth factor‐2 (FGF‐2) is mediated by shed vesicles. In the present study, we address the question of how newly synthesized FGF‐2 is targeted to the budding vesicles. Considering that in vitro cultured Sk‐Hep1 hepatocarcinoma cells release FGF‐2 and shed membrane vesicles only when cultured in ...
Taverna Simona +3 more
openaire +5 more sources
Action of fibroblast growth factor-2 on the intervertebral disc [PDF]
Arthritis Research & Therapy, 2008 Abstract Introduction Fibroblast growth factor 2 (FGF2) is a growth factor that is immediately released after cartilage injury and plays a pivotal role in cartilage homeostasis. In human adult articular cartilage, FGF2 mediates anti-anabolic and potentially catabolic effects via the suppression of ...
Hee Jeong Im +7 more
openaire +3 more sources
Coupling chemotaxis and growth poromechanics for the modelling of feather primordia patterning [PDF]
Mathematics, year 2022, volume 10, paper 4096, 2022 We propose a new mathematical model for the interaction of skin cell populations with fibroblast growth factor and bone morphogenetic protein, occurring within deformable porous media. The equations for feather primordia pattering are based on the work by K.J. Painter et al. [J. Theoret. Biol., 437 (2018) 225--238].
arxiv +1 more source
Definitions, 2020 Fibroblast growth factor 2 (288 aa, ~31 kDa) is encoded by the human FGF2 gene. This protein plays a role in the regulation of cell proliferation, angiogenesis, and limb and nervous system development.
semanticscholar +1 more source
Analysis of the Effects of Five Factors Relevant to In Vitro Chondrogenesis of Human Mesenchymal Stem Cells Using Factorial Design and High Throughput mRNA-Profiling [PDF]
, 2014 The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium.
Brinchmann, Jan E. +4 more
core +13 more sources
Effects of Fibroblast Growth Factor-2 on Longitudinal Bone Growth* [PDF]
Endocrinology, 1998 In vivo, fibroblast growth factor-2 (FGF-2) inhibits longitudinal bone growth. Similarly, activating FGF receptor 3 mutations impair growth in achondroplasia and thanatophoric dysplasia. To investigate the underlying mechanisms, we chose a fetal rat metatarsal organ culture system that would maintain growth plate histological architecture.
Francesco De Luca +4 more
openaire +3 more sources
Incorporation of FGF-2 into Pharmaceutical Grade Fucoidan/Chitosan Polyelectrolyte Multilayers
Marine Drugs, 2020 Biopolymer polyelectrolyte multilayers are a commonly studied soft matter system for wound healing applications due to the biocompatibility and beneficial properties of naturally occurring polyelectrolytes.
Natalie L. Benbow +3 more
doaj +1 more source
Circulating fibroblast growth factor-2 precipitates HIV nephropathy in mice
Disease Models & Mechanisms, 2021 People of African ancestry living with the human immunodeficiency virus-1 (HIV-1) are at risk of developing HIV-associated nephropathy (HIVAN). Children with HIVAN frequently show high plasma fibroblast growth factor-2 (FGF-2) levels; however, the role ...
Jharna R. Das +5 more
doaj +1 more source
Fibroblast Growth Factors 1 and 2 and Fibroblast Growth Factor Receptor 1 Are Elevated in Thyroid Hyperplasia [PDF]
The Journal of Clinical Endocrinology & Metabolism, 1998 We have previously reported increased expression of fibroblast growth factor (FGF-1 and FGF-2) in benign and malignant human thyroid neoplasia. To determine the role of these factors in thyroid hyperplasia we have examined their expression in multinodular goiter and compared findings with those in normal thyroid tissue. Because the effects of FGF-1 and
John Watkinson +5 more
openaire +3 more sources
Recombinant Fibroblast Growth Factor 2
Definitions, 2020 A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 2 (FGF-2). Reflecting its endogenous role, therapeutic FGF-2 exhibits a wide spectrum of biological activities, including the promotion of ...
semanticscholar +1 more source