Results 41 to 50 of about 8,552 (153)
FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
Scientific Reports, 2017 In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in
Edward R. Smith +3 more
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Regulation of fibroblast growth factor 23 (
FEBS Letters, 2019 Fibroblast growth factor 23 ( FGF 23) is mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho.
Ludmilla, Bär +3 more
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Nephrology Dialysis Transplantation, 2021 Abstract Background and Aims Mineral metabolism imbalances and inflammation are related to the development of vascular calcification (VC). Fibroblast growth factor-23 (FGF23) is the main regulator of phosphate homeostasis and various studies have shown the existence of an association between elevated ...
Javier Donate-Correa +10 more
openaire +1 more source
Case Reports in Medicine, 2012 Fibroblast growth factor 23 (FGF23) was recently identified as an important factor involved in the development of hypophosphatemic rickets and osteomalacia.
Shinya Hayashi +8 more
doaj +1 more source
Interactions between FGF23 and vitamin D
Endocrine Connections, 2022 Fibroblast growth factor‐23 (FGF23) controls the homeostasis of both phosphate and vitamin D. Bone-derived FGF23 can suppress the transcription of 1α‐hydroxylase (1α(OH)ase) to reduce renal activation of vitamin D (1,25(OH)2D3).
Mohammed S Razzaque
doaj +1 more source
FGF23 as a calciotropic hormone [version 1; referees: 2 approved]
F1000Research, 2015 Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol – 1,25(OH)2D3 – and induces phosphaturia.
María E. Rodríguez-Ortiz +1 more
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Nefrología (English Edition), 2019 Background: Fibroblast growth factor 23 (FGF23) is known to cause left ventricular hypertrophy (LVH), but controversy exists concerning its effect in dialysis.
Ture Lange Nielsen +5 more
doaj +3 more sources
Cell Death and Disease, 2021 The levels of fibroblast growth factor 23 (FGF23) rapidly increases after acute kidney injury (AKI). However, the role of FGF23 in AKI is still unclear.
Huang-Ming Chang +20 more
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The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors
Medicinal Research Reviews, EarlyView.ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti +6 more
wiley +1 more source
Assessment of the Serum Fibroblast Growth Factor 23 Level in Different Types of Rickets [PDF]
Zagazig University Medical JournalBackground: Worldwide, rickets had a significant impact on children and adolescents', growth, and development as well as their general health. The fibroblast growth factor 23 (FGF23) gene, which encodes a secreted protein that is related to the ...
Ihab Abd El Hamid +3 more
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