Results 41 to 50 of about 672,477 (393)

Angiogenesis-dependent and independent phases of intimal hyperplasia. [PDF]

, 2004
BACKGROUND: Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary cause of occlusive vascular disease, including atherosclerosis, restenosis after percutaneous interventions, and bypass graft stenosis. Angiogenesis is implicated in the
Bhardwaj, S, De Muinck, E, Ferrara, N, Khurana, R, Martin, JF, Murakami, M, Simons, M, Yla-Herttuala, S, Zachary, I, Zhuang, Z   +9 more
core   +1 more source

Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion [PDF]

Yixue xinzhi zazhi
Objective To investigate the causal relationship between fibroblast growth factors (FGFs), their receptors (FGFRs) and spontaneous abortion (SA). Methods FGFs, FGFRs, and SA related GWAS data were obtained from the FinnGen Alliance and Genome-wide ...
LI Jing, SUN Caixuan, LI Ao, XUE Yilu, WANG Runlin, TANG Yuyun, CAO Yuanyuan   +6 more
doaj   +1 more source

A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma

Journal of Biological Chemistry, 2016
Herein, we have identified cross-talk between the Hippo and fibroblast growth factor receptor (FGFR) oncogenic signaling pathways in cholangiocarcinoma (CCA).
S. Ilyas, Daisaku Yamada, P. Hirsova, S. Bronk, N. Werneburg, A. Krishnan, Warda Salim, Liang Zhang, E. Trushina, M. Truty, G. Gores   +10 more
semanticscholar   +1 more source

Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes. [PDF]

, 2011
INTRODUCTION: Cartilage degeneration driven by catabolic stimuli is a critical pathophysiological process in osteoarthritis (OA). We have defined fibroblast growth factor 2 (FGF-2) as a degenerative mediator in adult human articular chondrocytes ...
Chen, Di, Cool, Simon M, Im, Hee-Jeong, Mikecz, Katalin, Murphy, Gillian, van Wijnen, Andre J, Yan, Dongyao   +6 more
core   +5 more sources

Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]

, 2018
The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker, Barbaresi, Barton, Belleudi, Boukamp, Brooks, Candi, Capone, Chaffer, Dotto, Feng, Gaggioli, Getsios, Goetz, Grose, Harmon, Haugsten, Ishiwata, Izar, Jones, Kawase, Matsuda, Oh, Oltean, Peng, Petiot, Pickard, Pickard, Purpura, Raffa, Ramsey, Ranieri, Ranieri, Shamir, Shih, Simpson, Truong, Turner, Warzecha, Warzecha, Yang, Ye, Zhang, Zhao   +43 more
core   +1 more source

Roles of Fibroblast Growth Factor Receptors in Carcinogenesis [PDF]

Molecular Cancer Research, 2010
Abstract The fibroblast growth factor receptors (FGFR) play essential roles both during development and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that tightly regulate key biological processes, such as cell proliferation, survival, migration, and differentiation.
Sjur Olsnes, Ellen Margrethe Haugsten, Jørgen Wesche, Antoni G Wiedlocha   +3 more
openaire   +3 more sources

New Insight into the Anti-liver Fibrosis Effect of Multitargeted Tyrosine Kinase Inhibitors: From Molecular Target to Clinical Trials [PDF]

, 2016
Tyrosine kinases (TKs) is a family of tyrosine protein kinases with important functions in the regulation of a broad variety of physiological cell processes.
Chang Liu, Hongxin Zhang, Hulin Chang, Kai Qu, Sinan Liu, Ting Lin, Zhaoyong Yan, Zichao Huang   +7 more
core   +2 more sources

Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. [PDF]

, 2015
Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However,
Hamada, Yoshinosuke, Ito, Ayano, Kawaguchi, Naomasa, Kodaira, Moe, Matsuura, Nariaki, Mori, Seiji, Okazaki, Mika, Takada, Yoshikazu   +7 more
core   +7 more sources

Mechanism of Fibroblast Growth Factor in Alzheimer's Disease

Xiehe Yixue Zazhi
Alzheimer's disease(AD), the most common neurodegenerative disease, has shown an increasing incidence among younger people. With the onset of disease, most patients' cognitive function will show a progressive decline, bringing a heavy burden to the ...
WU Jiajing, LI Yan, LIANG Yuxia, HUA Huijuan, ZHAO Bo   +4 more
doaj   +1 more source

Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]

PLoS ONE, 2012
Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue, Alana L Welm, Marion Bouchecareilh, Kari Alitalo, Dean Y Li, Andreas Bikfalvi, Patrick Auguste   +6 more
doaj   +1 more source