Results 141 to 150 of about 10,651,893 (289)

Computational design of a pentapeptide inhibitor for fibroblast growth factor receptor 3b (FGFR3b)

TURKISH JOURNAL OF BIOLOGY, 2013
Fibroblast growth factor receptor (FGFR) is a cell membrane protein and a member of the tyrosine kinase family. It has extracellular domains that can be activated by ligand binding, followed by receptor dimerization. FGFR3 has 2 isoforms, 3b and 3c. The R248C mutation in FGFR3b leads to ligand independent receptor dimerization and results in different ...
openaire   +2 more sources

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

First-in-human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors. [PDF]

Cancer Sci, 2020
Koyama T, Shimizu T, Iwasa S, Fujiwara Y, Kondo S, Kitano S, Yonemori K, Shimomura A, Iizumi S, Sasaki T, Furuse J, Yamamoto N.   +11 more
europepmc   +1 more source

Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells

, 2011
Head and neck squamous cell carcinoma tumors (HNSCC) contain a dense fibrous stroma which is known to promote tumor growth, although the mechanism of stroma-mediated growth remains unclear.
Hartman, Yolanda E., Zhiyong Liu, Larissa Sweeny, Eben L. Rosenthal, Yolanda E. Hartman, Sweeny, Larissa, Jason M. Warram, Knowles, Joseph A., Tong Zhou, Warram, Jason M., Rosenthal, Eben L., Zhou, Tong, Liu, Zhiyong, Joseph A. Knowles   +13 more
core   +1 more source

Reduced Graphene Oxide Enhances the Vascular Organization and Contractile Performance of Fibrin‐Gelatin‐Based Engineered Cardiac Tissue

Advanced Materials Interfaces, EarlyView.
Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn, Marie Baiker, Yajuan Jiang, Ebru Aksoy, Kurt Pfannkuche, Horst Fischer   +5 more
wiley   +1 more source

Targeting fibroblast activation protein-α to treat renal fibrosis

Cellular & Molecular Biology Letters
Background Renal fibrosis is the common outcome of chronic renal disease. Currently, there are no effective therapies. Fibroblast activation and extracellular matrix accumulation are key processes driving renal fibrosis.
Li Gong, Xinyu Lu, Na Ma, Tao Lu, Yuhong Gong, Liwei Hao, Weikang Xu, Qianbing Zhang, Xiaolan Chen, Qinglin Mo, Jiexing Tan, Henrique de Paula Lemos, Alexander Speechley, Wenwei Tu, Jianpiao Cai, Lei Huang, Wei Zhu, Sha Wu   +17 more
doaj   +1 more source

Metastatic Calcinosis Cutis Secondary to Selective Fibroblast Growth Factor Receptor Inhibitor: Rapid and Complete Regression after Blood Phosphate Normalization and Drug Withdrawal. [PDF]

Acta Derm Venereol, 2020
Lopez-Castillo D, March-Rodriguez A, Rodriguez-Vida A, Pujol RM, Segura S.   +4 more
europepmc   +1 more source

Organoids as Building Blocks for Adaptive and Resilient Biohybrid Robots

Advanced Materials Technologies, EarlyView.
ABSTRACT Biohybrid robots combine engineered living tissues with synthetic materials and have emerged as a promising class of soft robotic systems capable of mimicking biological functions such as biodegradability, energy efficiency and flexible motions. By integrating biological and synthetic components, these systems leverage complementary properties
Antonia Georgopoulou
wiley   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Leveraging Healthy Volunteers for Anticancer Drug Clinical Pharmacology Studies: A Review Article Featuring Futibatinib as an Example

Clinical and Translational Science
Early clinical development of anticancer drugs traditionally focused on exploring candidate treatments in patients. For instance, due to their cytotoxic action, administration of chemotherapies to healthy volunteers (HVs) for evaluation of their ...
Aernout D. vanHaarst, Sabina Paglialunga, Ziv Machnes, Ikuo Yamamiya, Nanae Hangai, Aram Oganesian   +5 more
doaj   +1 more source