Results 41 to 50 of about 10,651,893 (289)

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Analysis of the mechanisms of resistance to Epidermal growth factor receptor inhibitors and development of multiple targeted strategies [PDF]

, 2008
Background. Primary and acquired resistance to selective Epidermal growth factor receptor (EGFR) inhibitors remains the most significant obstacle to the success of these targeted agents in cancer therapy.
Rosa, Roberta
core   +1 more source

Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21(waf1/cip1) [PDF]

, 2001
Background/Aims: We investigated the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on growth and TRAIL-induced apoptosis in carcinoid cells.
Göke, Burkhard, Göke, Rüdiger, Chen, Youhai, El-Deiry, Wafik S., Göke, Alexandra   +4 more
core   +1 more source

Dose-Dependent and Reversible Serous Retinal Detachments in Fibroblast Growth Factor Receptor Inhibitor-Associated Retinopathy

, 2023
We report two cases of fibroblast growth factor receptor (FGFR) inhibitor-associated retinop-athy, including the first case of Debio 1347 associ-ated retinopathy manifesting with bilateral serous retinal detachments along the superotemporal ar-cades and ...
Scott H. Greenstein, Kim, Leo A., Patel, Veshesh, Greenstein, Scott H., Eliott, Dean, Deep Parikh, Veshesh Patel, Nicolas Yannuzzi, Leo A. Kim, Dean Eliott, Parikh, Deep, Yannuzzi, Nicolas   +11 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Bilateral Subretinal Fluid Accumulation during Erdafitinib Therapy

TNOA Journal of Ophthalmic Science and Research
Fibroblast growth factor receptor (FGFR) plays a major role in maintaining retinal pigment epithelium cells. Drugs that inhibit the FGFR pathway block the activation of the mitogen-activated protein kinase pathway, leading to the synthesis of ...
Rajneesh Singh, Nipun Bagrecha, Suresh K. Pandey, Deepesh Chabblani   +3 more
doaj   +1 more source

Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Molecules, 2018
Fibroblast growth factor receptors (FGFRs), a subfamily of receptor tyrosine kinases, are aberrant in various cancer types, and considered to be promising targets for cancer therapy.
Alan Jiang, Qiufeng Liu, Ruifeng Wang, Peng Wei, Yang Dai, Xin Wang, Yechun Xu, Yuchi Ma, Jing Ai, Jingkang Shen, Jian Ding, Bing Xiong   +11 more
doaj   +1 more source

Functional dissection of the "Drosophila melanogaster" fibroblast growth factor signalling pathway in branching morphogenesis of the developing tracheal system [PDF]

, 2004
Fibroblast Growth Factor (FGF) signalling is involved in numerous developmental processes ranging from cell determination to mitogenesis, and cell survival to cell migration.
Dossenbach, Caroline
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source