Results 81 to 90 of about 1,904,768 (328)

Senescence in vitro and ionising radiations—the human diploid fibroblast model [PDF]

, 1981
The influence of ionising radiations on ageing is still controversial. Since Hayflick established the concept that diploid cells have finite lifespan in vitro, human diploid fibroblast (HDF) cultures have been recognised as a potent experimental model ...
A.F.G. Stevenson, Ban, Beer, Carrel, Cox, Cremer, Cristofalo, Ebeling, Finch, Fukushima, Guichard, Hayflick, Hayflick, Hayflick, Hoehn, Holliday, Holliday, Hopwood, Hug, Kaji, Kirkwood, Kirkwood, Laublin, Lima, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Maisin, Martin, Namba, Nicholas, Orgel, Orgel, Russ, Schneider, Schneider, Smith, Stevenson, T. Cremer, Walburg, Weismann, Williams, Wilson   +44 more
core   +1 more source

Roles of intracellular fibroblast growth factors in neural development and functions

Science China Life Sciences, 2012
Fibroblast growth factors (FGFs) can be classified as secretory (FGF1-10 and FGF15-23) or intracellular non-secretory forms (FGF11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation ...
Xu Zhang, L. Bao, Liu Yang, Qingfeng Wu, Shuai Li   +4 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

Journal of Neuroinflammation, 2019
Background Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities.
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus   +17 more
doaj   +1 more source

The Saga of Endocrine FGFs

Cells, 2021
Fibroblast growth factors (FGFs) are cell-signaling proteins with diverse functions in cell development, repair, and metabolism. The human FGF family consists of 22 structurally related members, which can be classified into three separate groups based on
Phuc Phan, Bibhuti Ballav Saikia, Shivakumar Sonnaila, Shilpi Agrawal, Zeina Alraawi, Thallapuranam Krishnaswamy Suresh Kumar, Shilpa Iyer   +6 more
doaj   +1 more source

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing. [PDF]

, 2019
Following injury, skin activates a complex wound healing programme. While cellular and signalling mechanisms of wound repair have been extensively studied, the principles of epidermal-dermal interactions and their effects on wound healing outcomes are ...
Chen, Weitao, Du, Huijing, Figueroa, Seth, Guerrero-Juarez, Christian F, Nie, Qing, Plikus, Maksim V, Qiu, Yuchi, Wang, Yangyang   +7 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +1 more source